TRADITIONAL POSTER - ismrm

Poster Sessions
1989. In Vivo 3D Imaging of Human Lateral Geniculate Nucleus Using Optimized Inversion Recovery
Sequence at 3T and 7T
Chan Hong Moon 1 , Jung-Hwan Kim 1 , JinHong Wang 1 , Kyongtae Ty Bae 1
1 University of Pittsburgh, Pittsburgh, PA, United States
We demonstrated excellent tissue contrast of the lateral geniculate nucleus (LGN) with suppression of signals from the surrounding white matters, such as
optic radiation using an (inversion-recovery) MPRAGE sequence with appropriate TI at 3T and 7T. The LGN was superiorly delineated with a high SNR at
7T, as compared to 3T. An imaging method that allows for accurate and reliable volume measurement of LGN is essential for the investigation of the
association between LGN atrophy in vivo and neurodegenerative glaucoma.
1990. Semi-Automatic Brain Ventricle Segmentation Using Partial Volume Fraction Calculation of CSF
Based on Quantitative MRI
J. B.M. Warntjes 1,2 , J. West 1,3 , R. Birgander 4 , P. Lundberg 5
1 Center for Medical Imaging Science and Visualization (CMIV), Linköping, Sweden; 2 Department of Medicine and Health, Division
of Clinical Physiology, Linköping, Sweden; 3 , Department of Medicine and Health, Division of Radiation Physics, Linköping,
Sweden; 4 Department of Radiology (NUS), Department of Radiation Sciences, Umeå, Sweden; 5 Department of Medicine and Health,
Division of radiation physics, Linköping, Sweden
A method is described to measure the partial volume fraction of cerebrospinal fluid for each voxel in a complete brain volume within a scan time of 5 to 6
minutes, based on quantification of the relaxation rates R1 and R2 and proton density. This measurement allows to accurately segment the brains ventricular
system independent of image resolution and without user-dependent image thresholding.
1991. Quantitative MR at 3.0 T of Patients with Non-Symptomatic Localization-Related Epilepsy:
Association with Generalized and Partial Seizures
Jacobus FA Jansen 1 , Marielle Vlooswijk 2 , H Majoie 2 , Paul Hofman 2 , Marc De Krom 2 , Albert Aldenkamp 2 ,
Walter H. Backes 2
1 Medical Physics, MSKCC, NY, United States; 2 MUMC, Maastricht, Netherlands
Although cognitive dysfunction is a prevalent co-morbidity in patients with chronic epilepsy, it is not clear whether these patients display cerebral
abnormalities that are related to the cognitive impairment that can be detected with in vivo magnetic resonance (MR) techniques. This report study aims to
determine neuronal determinants of cognitive impairment in patients with chronic epilepsy. Quantitative MR, comprising T2 relaxometry, diffusion tensor
imaging, and spectroscopic imaging, was applied to detect possible neuronal correlates in terms of micro-structural and metabolic abnormalities.
1992. Deformation Based Morphometry (DBM) in Temporal Lobe Epilepsy with and Without Mesial
Temporal Sclerosis
Cathy Scanlon 1 , Susanne G. Mueller 2 , Duygu Tosun 2 , Ian Cheong 2 , Michael W. Weiner 2 , Ken D. Laxer 3
1 Center for Imaging of Neurodegenerative Diseases , Dept. of Radiology and Biomedical Imaging, University of California,, San
Francisco, CA, United States; 2 Center for Imaging of Neurodegenerative Diseases, Dept. of Radiology and Biomedical Imaging,
University of California,, San Francisco, CA, United States; 3 Pacific Epilepsy Program, California Pacific Medical Center, San
Francisco, CA, United States
Deformation-based morphometry (DBM) was applied to 2 sub-groups of temporal lobe epilepsy (TLE); 15 patients with mesial temporal sclerosis (TLEmts)
and 14 with normal MRI on visual inspection (TLE-no). TLE-mts demonstrated extensive extra-hippocampal abnormalities when compared with
controls (n=33). TLE-no demonstrated more subtle but significant findings not previously reported with a similar analysis in voxel based morphometry
(VBM). This may suggest DBM to be a more sensitive approach to detect subtle volume changes in this group.
1993. Quantification of Microtubule Stabilizing Drug Treatment Effect on Axonal Transport Rate in a
Transgenic Mouse Model of Alzheimers Disease
Jieun Kim 1 , In-Young Choi 1,2 , Mary L. Michaelis 3 , Sang-Pil Lee 1,4
1 Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States; 2 Neurology, University of
Kansas Medical Center, Kansas City, KS, United States; 3 Pharmacology & Toxicology, University of Kansas, Lawrence, KS, United
States; 4 Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States
Axonal transport impairment has been implicated as a common mechanism of Alzheimerâ€s disease progression. A newly developed microtubule
stabilizing agent, TH237-A, is known for protecting neurons against A β toxicity, decreasing abnormal tau phosphorylation in cultured neurons, and
permeating the blood-brain barrier. We have investigated the efficacy of TH237-A in preserving axonal transport integrity in an animal model of AD, 3xTg-
AD mice, over one year by measuring axonal transport rates in olfactory bulbs using manganese enhanced MRI. Results show that the drug does not reverse
axonal transport deficits but may be effective in preventing further axonal transport impairment.
1994. Imaging Correlates of Neuropsychological Tests in Minimal Hepatic Encephalopathy Due to
Extrahepatic Portal Vein Obstruction
Santosh Kumar Yadav 1 , Amit Goel 2 , Vivek A. Saraswat 3 , Arti Srivastava 1 , Sanjay Verma 4 , Ram Kishore S.
Rathore 5 , Michael A. Thomas 6 , Chandra M. Pandey 7 , Kashi N. Prasad 4 , Rakesh K. Gupta 1
1 Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 2 Gastroenterology,
Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow India, Lucknow, UP, India; 3 Gastroenterology, Sanjay Gandhi
Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 4 Mathematics and Statistics, Indian Institute of
technology, Kanpur, UP, India; 5 Mathematics and Statistics, Indian Institute of technology Kanpur, Kanpur, Uttar Pradesh, India;