TRADITIONAL POSTER - ismrm

Poster Sessions
resolution demands and motion. Presumably, spinal cord qMT studies would benefit from the increased SNR at 3T; however, such studies are limited by
SAR constraints. To address these issues, we developed a high resolution qMT imaging protocol of the cervical spinal cord at 3T and acquired data in
healthy subjects.
2461. Fast Simultaneous Acquisition of High-Resolution Brain and Cervical Spinal Cord T1w Images to
Measure Spinal Cord Atrophy: Methods and Validation
Patrick Anton Bruno Freund 1,2 , Catherine Dalton 3 , Claudia Angela Michela Wheeler-Kingshott 3 , Janice
Glensman 1 , David Bradbury 1 , Alan James Thompson 2 , Nikolaus Weiskopf 1
1 Wellcome Trust Centre for Neuroimaging, UCL Institue of Neurology, London, United Kingdom; 2 Brain Repair and Rehabilitation,
UCL Institue of Neurology, London, United Kingdom; 3 Neuroinflammation, UCL Institue of Neurology, London, United Kingdom
We have developed and validated a method for fast, simultaneous and high-quality imaging of the brain and cervical spinal cord (< 14 mins., 1 mm isotropic
resolution) with the potential to detect, besides volumetric changes at cortical level, also changes at cervical level. It is based on a 3D MDEFT scan using an
8-channel receive head coil. Measures of cross sectional cord area, obtained with the MDEFT-based method, are in good agreement with the established
standard based on 3D MPRAGE scans with dedicated spine coils, as determined in a group of healthy controls and subjects with traumatic cervical spinal
cord injury.
2462. Magnetic Resonance Spectroscopy of the Cervical Spine in ALS and Pre-Symptomatic SOD1 Positive
People
John D. Carew 1,2 , Govind Nair 3 , Sharon Usher 4 , Xiaoping P. Hu 3 , Michael Benatar 4
1 Carolinas HealthCare System, Charlotte, NC, United States; 2 Biostatistics and Bioinformatics, Emory University, Atlanta, GA;
3 Biomedical Engineering, Emory University; 4 Neurology, Emory University
We studied MRS in the cervical spinal cord of amyotrophic lateral sclerosis (ALS) patients, healthy controls, and people with a mutation in the SOD1 gene.
Single voxel PRESS/CHESS MRS was used to measure NAA, choline, creatine, and myo-inositol. We found metabolic changes in both ALS and people
positive for the SOD1 mutation. Among ALS patients, metabolite ratios correlate with clinical measures of disease severity. The findings in the SOD1
positive sample suggests that metabolic changes occur prior to the onset of clinical symptoms.
2463. In Vivo MR Spectroscopic Changes in the Brain and Spinal Cord After Experimental Spinal Cord
Injury in Rats
Johanna Oberg 1 , Matthias Erschbamer 2 , Rouslan Sitnikov 1 , Eric Westman 3 , Christian Spenger 1 , Lars
Olson 2
1 CLINTEC, Karolinska Institutet, STOCKHOLM, Sweden; 2 Neuroscience, Karolinska Institutet, Sweden; 3 NEUROTEC, Karolinska
Institutet, Sweden
A variety of tests of sensorimotor function are used to characterize outcome after experimental spinal cord injury (SCI). These tests, however, do not provide
information about chemical and metabolic processes in the injured CNS. Here, proton magnetic resonance spectroscopy (MRS) was used to monitor
chemical changes in CNS (brain and spinal cord) in vivo following SCI. Significant differences were found between control rats and injured rats.
Multivariate data analysis was applied. Our findings suggest that MRS is a helpful tool to monitor metabolic changes in vivo in the brain and the spinal cord
itself after spinal cord injury.
2464. High-Field in Vivo 1H-MR Spectroscopy of the Injured Mouse Spinal Cord. Feasibility and
Potentiality.
Virginie Callot 1 , Guillaume Duhamel 1 , Mohamed Tachrount 1 , Yann Le Fur 1 , Patrick J. Cozzone 1
1 Centre de Résonance Magnétique Biologique et Médicale (CRMBM), CNRS, UMR 6612, Faculté de Médecine, Marseille, France
Non invasive investigations of the mouse spinal cord pathologies are currently based on anatomic and diffusion MRI. In this work, we investigated whether
high-field MR Spectroscopy would be able to provide complementing biochemical information useful to describe the lesion and the repair processes. This
preliminary study demonstrates the feasibility of longitudinal follow-ups with localized 1H-MRS in injured mouse spinal cord.
2465. In Vivo MR High Resolution T1rho Mapping of the Spine at 3T Using a Reduced-FOV Approach
Ajit Shankaranarayanan 1 , Emine U. Saritas 2 , Dwight G. Nishimura 3 , Weitian Chen 1 , Eric Han 1
1 Global Applied Science Lab, GE Healthcare, Menlo Park, CA, United States; 2 Dept of Electrical Engineering, Stanford University,
Palo Alto, CA, United States; 3 Dept of Electrical Engineering, Stanford University, Palo Alto, CA, United States
It has been suggested that MR T1ñ relaxation time may potentially be valuable to assess proteoglycan (PG) loss in the early stages of disc degeneration, a
known cause for back pain. Previous T1ñ mapping techniques have shown this to be true. However, clinical applicability of these techniques in spine is
somewhat limited by either long scan time, lower resolution or insufficient coverage. This work aims to overcome these limitations by applying reduced-
FOV technique, previously shown for diffusion imaging to T1ñ imaging. In vivo experiments have been performed on 3T to show the usefulness of such a
targeted approach in terms of higher resolution and shorter scan times while providing good coverage in spine.
2466. Ultrashort TE Imaging After Percutaneous Vertebroplasty
Akio Hiwatashi 1 , Takashi Yoshiura 1 , Koji Yamashita 1 , Hironori Kamano 1 , Hiroshi Honda 1
1 Clinical Radiology, Kyushu University, Fukuoka, Japan
uTE is feasible to evaluate cement distribution after percutaneous vertebroplasty