TRADITIONAL POSTER - ismrm

Poster Sessions
2423. Diffusion Tensor Imaging Correlates of Cognitive Impairment and Fatigue in Multiple Sclerosis
Gunja P. Parikh 1 , Maxim Bester 1,2 , Mariana Lazar 1 , James S. Babb 1 , Hina Jaggi 1 , Laura Miles 1 , Robert
Grossman 1 , Matilde Inglese 3,4
1 Radiology, New York University, New York, NY, United States; 2 Neuroradiology, Eppendorf-Hamburg University, Hamburg,
Germany; 3 Radiology , New York University, New York, NY, United States; 4 Neurology, New York University, New York, NY,
United States
Diffusion tensor tractography provides the possibility to reconstruct fiber bundles and to focus on regions that might play a major role in the development of
clinical deficits in patients with multiple sclerosis (MS). We used tractography to determine whether tissue damage in the corpus callosum (CC) and in the
anterior-thalamic tracts (AT) is associated with cognitive dysfunction and fatigue in patients with benign MS (BMS) and clinically isolated syndrome (CIS).
Differences from controls were observed in the CC and AT tracts of BMS and CIS patients. A significant association was found between DTI metrics in the
CC and cognitive deficits.
2424. The Effects of HIV and Aging Using Diffusion Tensor Imaging
Huiling Peng 1 , Joseph Mettenburg 2 , Avi Snyder 1 , David Clifford 1 , Tammie Benzinger 2 , Beau Ances 3
1 Neurology, Washington University in St. Louis, St. Louis, MO, United States; 2 Radiology, Washington University in St. Louis, St.
Louis, MO, United States; 3 Neurology, Washington University in St. Louis, St. Louis, MO , United States
HIV can lead to chronic inflammation. We investigated the relationship between aging and HIV status and white matter integrity using DTI in four groups of
participants (HIV younger (20-25 years old) (n=8), HIV- older (50-65 years old) (n=12), HIV+ younger (20-25 years old) (n=9), and HIV+ older (50-65
years old) (n=9)). Regions-of-interest corresponding to the genus, middle, and splenium were selected. HIV- older subjects had significant decreases in mean
diffusivity, axial diffusivity (AD), and radial diffusivity (RD) compared to other all groups. While HIV led to a reduction in DTI measures these decreases
were not significant.
2425. Differences in White Matter Fiber Orientation in Three Clinical Groups of Children: Reading
Disability, NF-1 and Reading Disability, and Controls
Daniel Jon Peterson 1 , Sheryl L. Rimrodt 2,3 , Laurie E. Cutting 4
1 Developmental Cognitive Neurology, The Kennedy Krieger Institute, Baltimore, MD, United States; 2 Division of Developmental
Medicine, Children's Hospital at Vanderbilt, Nashville, TN, United States; 3 Developmental Cognitive Neurology, Kennedy Krieger
Institute, Baltimore, MD, United States; 4 Kennedy Center for Research and Development, Vanderbilt University, Nashville, TN,
United States
DTI was used to investigate differences in white matter fiber orientation between three groups: children with reading disability (RD), children with
neurofibromatosis type 1 and reading disability (NF1+RD), and typically developing controls. A voxel-wise statistical test that detects differences in fiber
orientation revealed bilateral differences in the anterior limb of the internal capsule. In this region, the fiber orientation of controls and RD subjects were
similar, while those of the NF1+RD subjects clearly differed, with minimal overlap.
2426. Voxel-Based Morphometric Analysis of Brain Volumetry and Diffusivity in Hepatitis C
Manoj Kumar Sarma 1 , Rajakumar Nagarajan 1 , Charles H. Hinkin 2 , Steven A. Castellon 2 , Jason P. Smith,
Homayoon Khanlou 3 , Laveeza Bhatti 3 , Jonathan Truong 4 , E Singer 5 , Jiah Jang 6 , Michelle Kim 6 , Gabe
Waterman 6 , Rakesh Kumar Gupta 7 , Michael Albert Thomas 1
1 Radiological Sciences, UCLA, Los Angeles, CA, United States; 2 Psychiatry and Biobehavioral Sciences, UCLA School of Medicine
and VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States; 3 AIDS Healthcare Foundation, Los Angeles, CA,
United States; 4 Kaiser Permanente, Lancaster, CA, United States; 5 Neurology, UCLA School of Medicine, Los Angeles, CA, United
States; 6 VA West Los Angeles Healthcare System, Los Angeles, CA, United States; 7 Radiological Sciences, SGPGIMS, Lucknow,
UP, India
We investigated mean diffusivity (MD) and fractional anisotropy (FA) value changes along with white matter and gray matter volume in patients with
hepatitis C compared to healthy controls using voxel based morphometry (VBM). Extensive increased MD values were observed in bilateral frontal gray and
white matter, bilateral external capsule, temporal white matter, and right occipital gray matter. FA values decreased in the corpus callosum, right frontal and
occipital white matter. Widespread gray matter volume reduction was seen in the frontal, parietal and temporal regions. White matter volume decreases were
observed in the right frontal, corpus callosum and mid brain.
2427. DTI Detects Progressive Neurodegeneration in the Brain and Cervical Spinal Cord in ALS
Govind Nair 1 , John D. Carew 2,3 , Longchuan Li 1 , Sharon Usher 4 , Xiaoping P. Hu 1 , Michael Benatar 4,5
1 Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, United States; 2 Institute
for Health Studies, Carolinas HealthCare System, Charlotte, NC, United States; 3 School of Public Health, Emory University, Atlanta,
GA, United States; 4 Department of Neurology, Emory University, Atlanta, GA, United States; 5 Department of Epidemiology, Emory
University, Atlanta, GA, United States
Diffusion tensor imaging of the brain and spinal cord in patients with Amyotrophic Lateral Sclerosis and age-matched healthy control subjects revealed a
significant decrease in fractional anisotropy, and increase in mean diffusivity and radial diffusivity along the corticospinal tract. The DTI parameters from
ALS patients showed significant correlation with their average finger and foot tapping speed, a measure of upper motor neuron dysfunction. These findings
suggest that DTI might represent useful imaging biomarkers of ALS disease progression.