TRADITIONAL POSTER - ismrm

Poster Sessions
2620. Clinical Experience with Gadoxetate-Enhanced T1 Weighted Hepatobiliary Imaging in Primary
Sclerosing Cholangitis
Andrzej Roman Jedynak 1 , Frederick Kelcz 1 , Alex Frydrychowicz 1 , Scott K. Nagle 1,2 , Scott B. Reeder 1,3
1 Radiology, University of Wisconsin, Madison, WI, United States; 2 Radiology, Middleton Veterans Affairs (VA) Hospital, Madison,
WI, United States; 3 Medical Physics, University of Wisconsin, Madison, WI, United States
Primary sclerosing cholangitis (PSC) is a chronic inflammatory condition of extra- and intra-hepatic biliary ducts. In our clinical practice we routinely use
the combination of high resolution gadoxetate-enhanced T1-MRC and heavily T2-weighted MRCP for the evaluation of PSC. This work set out to validate
the clinical diagnostic utility of adding high-resolution 3D T1-weighted gadoxetate-enhanced hepatobiliary phase MRC to 3D T2 weighted MRCP.
Preliminary results indicate that T1-MRC is an excellent adjunct to T2 MRCP that provides not only anatomical visualization of the biliary tree and
associated disease but also offers useful functional/physiologic information that can be tremendously helpful in many cases.
2621. Gd-EOB-DTPA as a Correlate for Chronic Liver Disease Through Contrast Uptake, Uptake Rate, and
Bile Excretion
Hiroumi Kitajima 1 , Puneet Sharma, Christina Lurie, Khalil Salman, Gaye Ray, Bobby Kalb, Diego Martin
1 Emory University, Atlanta, GA, United States
Gd-EOB-DTPA demonstrates liver clearance kinetics that allow for its use as a marker for patients with chronic liver disease. Signal uptake, uptake rate,
and common bile duct excretion as imaged by 3D T1-weighted GRE allow for quantitative assessment of liver fibrosis.
2622. MR Cholangiopancreatography: Does Butylscopolamine (Buscopan®) Make a Difference to Ductal
Visualization?
Natalie Yang 1 , Sarah Jenkins 1 , Errol Colak 1 , Anish Kirpalani 1
1 Radiology, St Michael's Hospital, Toronto, Ontario, Canada
The effect of butylscopolamine (Buscopan) on image quality for MR cholangiopancreatography (MRCP) examinations is examined in our study. The
inferior common bile duct demonstrated improved visualization after the administration of butylscopolamine whilst other ductal segments demonstrated
minimal benefit. The use of butylscopolamine in patients with suspected inferior common bile duct disease improves image quality and thus may improve
diagnosis.
2623. MRI of Intrabiliary Delivery of Motexafin Gadolinium Into Common Bile Duct Walls: In Vitro and Ex
Vivo Evaluations
feng zhang 1 , Huidong Gu 1 , Yanfeng Meng 1 , Bensheng Qiu 1 , Xiaoming Yang 1
1 Image-Guided Bio-Molecular Intervention Section, Department of Radiology, University of Washington School of Medicine, Seattle,
WA, United States
MR imaging was used to investigate the capability of Motexafin gadolinium(MGd) entering human cholangiocarcinoma cells (Mz-ChA-1) and the feasibility
of intrabiliary local delivery of MGd into the common bile duct(CBD) wall. T1 weighted MR imaging of Mz-ChA-1 cells treated with MGd demonstrated a
linear increase of signal intensities(SI) from 25 to 75-¦Ìg/mL MGd, and a plateau pattern of SIs from 75 to 150-¦Ìg/mL MGd. Confocal microscopy showed
MGd internalized Mz-ChA-1 cells as intracytoplasm pink dots. Ex vivo experiments revealed significant higher contrast-to-noise ratio in the MGd-infused
CBD walls than that in the controlled CBD walls with phosphate-buffered saline.
2624. 7T Liver MRI in Humans: Initial Results.
Lale Umutlu 1 , Andreas K. Bitz 2 , Stefan Maderwald 3 , Stephan Orzada 3 , Sonja Kinner 4 , Oliver Kraff, Irina
Brote, Susanne C. Ladd, Gerald Antoch, Mark E. Ladd 3 , Harald H. Quick 3 , Thomas C. Lauenstein
1 Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen , Essen, Germany; 2 Erwin
L.Hahn Institute for Magnetic Resonance Imaging, Essen, Germany; 3 2Erwin L.Hahn Institute for Magnetic Resonance Imaging;
4 1Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen
Aim of this study was to investigate the feasibility of 7 Tesla liver MRI, with optimization and implementation of a dedicated examination protocol. 8
healthy subjects were examined at a 7T whole-body MR system utilizing a custom-built 8-channel RF transmit/receive body coil. Delineation of liver
vessels, overall image quality and presence of artifacts was assessed. T1w imaging revealed very good delineation of liver vasculature, with best imaging
scores for T1w 2D FLASH imaging. T2w TSE imaging remained strongly impaired by artifacts. This pilot study of dedicated hepatic imaging at 7 Tesla
demonstrates the feasibility of in vivo ultra-high-field liver imaging.
2625. In Vivo Evaluation of Exocytic Activity in Kupffer Cells Using Superparamagnetic Iron Oxide-
Enhanced Magnetic Resonance Imaging; an Experimental Study on Gadolinium Chloride-Induced Liver Injury
in Rats.
Toshihiro Furuta 1,2 , Masayuki Yamaguchi 1 , Ryutaro Nakagami 1,3 , Akira Hirayama 1,4 , Masaaki Akahane 2 ,
Manabu Minami 5 , Kuni Ohtomo 2 , Hirofumi Fujii 1
1 Functional Imaging Division, National Cancer Center Hospital East, Kashiwa, Chiba, Japan; 2 The University of Tokyo Hospital,
Bunkyo-ku, Tokyo, Japan; 3 Graduate School of Human Health Sciences, Tokyo Metropolitan University, Arakawa, Tokyo, Japan;
4 GE Healthcare Japan, Hino, Tokyo, Japan; 5 Tsukuba University Hospital, Tsukuba, Ibaraki, Japan
Hepatic signal recovery on MR images after a single dose of superparamagnetic iron oxide (SPIO) would be well correlated with exocytic activity of
Kupffer cells (KCs). In this study, we actually showed the delay of hepatic signal recovery after SPIO administration depending on the severity of KCs'
injury in an animal model, in which rat KCs were injured by intravenous administration of gadolinium chloride in a dose-dependent manner. We believe that
at least two-week follow up MR imaging scans after SPIO administration are useful for the evaluation of not only phagocytic but also exocytic activities of
KCs.