TRADITIONAL POSTER - ismrm

Poster Sessions
Arterial Spin Labeling: Non-Brain
Hall B Tuesday 13:30-15:30
1777. Comparing Kidney Perfusion Using Arterial Spin Labeling and Microsphere Methods in an
Interventional Swine Model
Nathan S. Artz 1 , Andrew L. Wentland 1 , Elizabeth A. Sadowski 2 , Thomas M. Grist, 12 , Arjang Djamali 3 , Sean
B. Fain 1,2
1 Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 2 Radiology, University of Wisconsin-Madison,
Madison, WI, United States; 3 Nephrology, University of Wisconsin-Madison, Madison, WI, United States
Two methods of measuring cortical kidney perfusion, fluorescent microspheres and ASL-FAIR, are compared for 11 swine each at four interventional time
points: 1) under baseline conditions, 2) during an acetylcholine and fluid bolus challenge to increase perfusion, 3) initially after switching to isoflurane
anesthesia , and 4) after two hours of isoflurane anesthesia. Across all swine, microspheres and ASL correlated (r = 0.72) and each technique tracked the
expected perfusion changes due to the interventions, demonstrating statistical differences in perfusion (p < 0.05) between time points. In addition, ASL
perfusion data was more consistent across swine. This data provides validation of ASL-FAIR for relative renal perfusion imaging, especially for evaluating
time-averaged perfusion changes that may be observed in chronic disease.
1778. Arterial Spin Labelling Characterisation of Renal Medullary Perfusion
Philip M. Robson 1 , David C. Alsop 1
1 Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States
Arterial spin labelling (ASL) has recently been used for measuring renal perfusion. Perfusion is highest in the renal cortex, but the outer medulla is the most
prone to hypoxic injury. Accurate quantification of outer medullary perfusion can be complicated by partial volume averaging with cortical signal and by
loss of label in the cortex before transit to the medulla. Here we evaluate high resolution ASL MRI with different labelling strategies to assess the feasibility
of quantifying outer medullary perfusion with ASL.
1779. Quantitative Mouse Renal Perfusion Imaging Using Arterial Spin Labeling
Reshmi Rajendran 1 , Cai-Xian Yong 1 , Jolena Tan 1 , Jiongjiong Wang 2 , Kai-Hsiang Chaung 1
1 Lab of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore; 2 University of Pennsylvania, United States
Synopsis We demonstrated quantitative renal perfusion in mice using ASL MRI. Perfusion was measured using a FAIR spin-echo EPI. Respiratory motion,
susceptibility and fat artifacts were controlled by triggering, high-order shimming, and water excitation, respectively. High perfusion signal was obtained in
the cortex compared to the medulla and signal was absent in scans carried out post mortem. Change in the cortical perfusion was observed after manipulating
gas compositions including 5% CO2.
1780. Image Registration in ASL-Perfusion Imaging of Kidney - Impact on Image Quality
Kiril Schewzow 1 , Frank Gerrit Zöllner 1 , Niels Oesingmann 2 , Lothar Rudi Schad 1
1 Department of Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany; 2 Siemens Healthcare, New York,
United States
ASL techniques suffer from low SNR and especially in abdominal imaging, from organ movements, e.g. breathing. In this work, we analyzed the impact of
automatic image registration on signal quality and increase of SNR by averaging in ASL kidney perfusion imaging. To evaluate the registration we
compared results to manual registration based on landmarks. Both registration techniques improve the image quality significantly. However, the automatic is
the preferred method for large data sets. In addition, a higher SNR is reached contributing to reliable quantification.
1781. Isotropic Resolution 3D Fast Spin Echo Acquisition for Quantitative Arterial Spin Labelled Perfusion
Imaging in the Kidneys
Philip M. Robson 1 , Ananth J. Madhuranthakam 2 , David C. Alsop 1
1 Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States; 2 Applied Science Laboratory, GE Healthcare, Boston,
MA, United States
Most studies using arterial spin labelling (ASL) for perfusion in the abdomen have used 2D acquisitions in a limited number of slices. We evaluated 3D Fast
Spin Echo (3D FSE) imaging for volumetric acquisition of perfusion in the kidneys. In sagittal image volumes over each kidney, isotropic 2.6-mm
resolution was achieved allowing assessment in any orientation. Quantitative perfusion values were found to be comparable to a 2D ASL single-shot FSE
sequence, and gave values for total renal blood flow that are in broad agreement with physiological values.
1782. Layer-Specific Blood-Flow MRI of Retina Degeneration at 11.7T
Guang Li 1 , Bryan De La Garza 2 , Eric Raymond Muir, 2,3 , Timothy Q. Duong 4
1 Research Imaging Institute, Ophthalmology/Radiology, UT Health Science Center at San Antonio, San Antonio, TX, United States;
2 Research Imaging Institute, UT Health Science Center at San Antonio, San Antonio, TX, United States; 3 Biomedical Engineering,
Georgia Institute of Technology, Atlanta, GA, United States; 4 2Research Imaging Institute, Ophthalmology/Radiology, UT Health
Science Center at San Antonio, San Antonio, TX, United States
Vision loss due to retinal degeneration is a major problem in ophthalmology. We have previously reported a thinning of the retina and perturbed BOLD
fMRI responses to physiologic challenges in the retina of an animal model of progressive retinal degeneration, Royal-College-of-Surgeons (RCS) rats. In
this study, we extend previous findings by developing layer-specific basal blood flow (BF) MRI to investigate BF changes in RCS rat retinas and agematched
controls at 43 x 43 x 600 um 3 on 11.7T. Quantitative BF was measured using the continuous arterial-spin-labeling technique. MRI provides layerspecific
quantitative BF data without depth limitation and a large field-of-view.