TRADITIONAL POSTER - ismrm

Poster Sessions
2636. Could Obesity Possibly Be Harmless
Lidia S. Szczepaniak 1 , Jaime L. Legendre 2 , Edward W. Szczepaniak 1 , Angela L. Price 2 , Ildiko Lingvay 2
1 The Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States; 2 Endocrinology, UT Southwestern Medical
Center, Dallas, TX, United States
There is no doubt that obesity is associated with diabetes, increased cardiovascular risk factors, not to mention arthritis and cancers. Sixty to 90% of patients
with diabetes are obese but not all obese individuals present metabolic and cardiovascular diseases. This leads to a notion that certain individuals tolerate
obesity well and without metabolic consequences. We present clinical evidence that given enough time the so called "healthy obesity" eventually becomes
harmful with full spectrum of metabolic consequences.
2637. Beneficial Effects of Diethylnorspermine in Obesity and Its Cardiac Complications
MingMing Li 1 , Beau Pontre 2 , Stephen Pickup 3 , Hong Xu 4 , Anthony Philips 2 , Garth Cooper 2 , Jun Lu 2,5
1 School of Biological Sciences, Auckland University, Auckland, New Zealand; 2 School of Biological Sciences, Auckland University,
New Zealand; 3 Department of Radiology, University of Pennsylvania, Philadelphia, United States; 4 College of Chemistry and
Chemical Engineering, Shen Zhen University, Shenzhen, Guangdong, China; 5 NCIECP, Auckland University of Technology,
Auckland, New Zealand
We hypothesise that chemically induced Spermidine/spermine acetyl transferase (SSAT) activity, which stimulates polyamine catabolism and in turn
enhances fat/glucose metabolism, would decrease fat content and improve cardiac function in obese mice. C57Bl/6 and matched leptin deficiency (ob/ob)
mice were treated with a potent SSAT inducer, N1, N11-diethylnorspermine (DENS), through i.p. injection. Results showed that DNES not only can
significantly reduce body fat percentages in both mice models, but also can control ob/ob’s body weight. Moreover, DENS can prevent the development of
cardiac hypertrophy in obese mice. Therefore, SSAT is a potential target for the development of pharmacotherapy in obesity.
2638. Patient Specific T 2 correction in Hepatic Fat Content Measurement in Obese Patients
Annie M. Tang 1 , Kelvin K. Wong 1 , Kathleen Wyne 2,3 , Dikoma C. Shungu 4 , Willa Hsueh 2,5 , Stephen T. Wong 1
1 Center for Bioengineering and Informatics and Department of Radiology, The Methodist Hospital Research Institute, Weill Cornell
Medical College, Houston, TX, United States; 2 Diabetes Research Center, The Methodist Hospital Research Institute, Houston, TX,
United States; 3 Division of Diabetes, Obesity & Lipids, The Methodist Hospital, Weill Cornell Medical College, Houston, TX, United
States; 4 Department of Radiology, Weill Cornell Medical College, Cornell University, New York, NY, United States; 5 Division of
Diabetes, Obesity & Lipids , The Methodist Hospital, Weill Cornell Medical College, Houston, TX, United States
1 H-MRS is used for quantifying liver fat content in patients with NAFLD. T2 corrections of hepatic fat/water are usually done using T2 values obtained in
literature. However, these T2 values of depends a lot on the concentration of iron in the liver. In patients with NAFLD, different degree of iron
concentration was observed depending on the patient sex and diabetes status. We are conducting an ongoing pilot trial to study the hepatic fat content in
obese patients before and during diet/weight management. The hepatic water and fat T2 relaxation values were measured and its effects in hepatic fat
content measurements were explored.
2639. Triglyceride Composition Measured by 1 H MRS at Clinical Field Strengths
Gavin Hamilton 1 , Michael S. Middleton 1 , Takeshi Yokoo 1 , Mark Bydder 1 , Michael E. Schroeder 1 , Claude B.
Sirlin 1
1 Department of Radiology, University of California, San Diego, San Diego, CA, United States
The multi-peak structure of the fat 1 H MR spectrum allows the triglyceride composition in adipose tissue to be estimated non-invasively. We assess the
ability of 1 H MR spectroscopy to reproducibly provide information about triglyceride composition in adipose tissue in vivo at clinical field strengths.
2640. In Vivo Repeatability of Liver Fat Measurement Using 1 H MR Spectroscopy
Gavin Hamilton 1 , Michael S. Middleton 1 , Takeshi Yokoo 1 , Masoud Shiehmorteza 1 , Claude B. Sirlin 1
1 Department of Radiology, University of California, San Diego, San Diego, CA, United States
We examined the repeatability of the liver fat fraction given by MR Spectroscopy. We measured the fat fraction at 3T in vivo by collecting five single
average STEAM spectra at progressively longer of TEs of 10, 15, 20, 25 and 30 ms in a single breath-hold to generate T2 and T2-corrected peak areas. We
repeated this measurement three times per subject and showed this method produced highly repeatable liver fat fraction and water T2 estimates. This
method did not produce a repeatable estimate of fat T2.
2641. On the Evaluation of 31P MRS Human Liver Protocols.
Mikael F. Forsgren 1 , Olof Dahlqvist Leinhard 2,3 , Bengt Norén 4 , Stergios Kechagias, Fredrik H. Nyström,
Örjan Smedby 2,3 , Peter Lundberg, 3,4
1 Linköping University; 2 Faculty of Health Sciences/IMH, Linköping University, Linköping, Sweden; 3 Center for Medical Image
Science and Visualization (CMIV), Linköping University, Linköping, Sweden; 4 Radiology, Linköping University Hospital
In this study the effect of proton decoupling, nuclear overhauser enhancement and repetition time was investigated in 31P liver MRS at 1.5T. An optimal
protocol was determined and validate on 13 healthy volunteers.