TRADITIONAL POSTER - ismrm

Poster Sessions
predominately from bulk tissue (excluding vessels). This method of analysis provided a robust result, with minimal variation in the peak data when the
shape of the mask was altered. A significant spread in measured peak relaxation times is found in patients with chronic liver disease.
2604. Measuring T 2 in the Liver. a Comparison Between 1 H Spectroscopy and SE-EPI
Caroline L. Hoad 1 , Mary Stephenson 1 , Ji-Young Lim 1 , Alexander G. Gardener 1 , Carolyn Costigan 2 , Robin
C. Spiller 3 , Penny A. Gowland 1 , Luca Marciani 3 , Guru P. Aithal 3 , Susan T. Francis 1
1 School of Physics and Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2 Brain and Body
Centre, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 3 Nottingham Digestive Diseases Centre, NIHR
Biomedical Research Unit, University Hospitals NHS Trust, Nottingham, Nottinghamshire, United Kingdom
Relaxation time T 2 was measured in liver water tissue of 18 chronic liver disease patients using multiple TE MRS and SE-EPI T 2 mapping. There was good
agreement between T 2 measured using MRS and the mean T 2 measured across the liver maps (including blood vessels), however peak (mode) T 2 data from
the EPI maps (bulk tissue only) consistently measured a shorter T 2 compared to the MRS data, suggesting the MRS data ‘tissue’ T 2 contained some
components from blood. There was considerable variation in T 2 of the liver of patients with chronic liver disease possibly reflecting differences in iron
content and liver fibrosis.
2605. Fast 3D Dynamic Contrast-Enhanced MRI Pre- And Post-Secretin for Evaluating the Severity of
Chronic Pancreatitis
Patrick Hawkins 1 , Numan C. Balci 2 , Sharon C. Forrest 3 , Frank Burton 4 , Samer Alkaade 4 , Thomas Perkins 5 ,
William H. Perman 1
1 Radiology, Saint Louis University School of Medicine, St. Louis, MO, United States; 2 Radiology, Saint Louis University, St. Louis,
MO, United States; 3 Department of Radiology, Saint Louis University Hospital, St. Louis, MO, United States; 4 Department of Internal
Medicine, Saint Louis University School of Medicine, St. Louis, MO, United States; 5 Philips Healthcare, Cleveland, OH, United
States
Currently, secretin stimulation is utilized in MRCP Cambridge classification of chronic pancreatitis. Our study intends to correlate pre- and post-secretin
pancreas perfusion with a more precise classification of chronic pancreatitis. Fast 3D dynamic contrast-enhanced MR perfusion scans were performed on 12
subjects with suspected chronic pancreatitis using a 3D T1 weighted turbo field echo pulse sequence. Comparison of the perfusion values between
Cambridge type 3 and type 1 subjects, with normal exocrine function demonstrate a significant difference in regional and average arterial to tissue wash-in
and wash-out rates. Conclusion: Contrast-enhanced MRI shows promise as a staging technique for chronic pancreatitis.
2606. Investigating Iron Deposition in Hepatic Diseases Using Susceptibility Weighted Imaging - Initial
Experiment
Yongming Dai 1 , Daoying Gen 2 , Jiani Hu 3 , E.M. Haacke 3
1 Siemens Ltd China, Healthcare, Magnetic Resonance Imaging, Shanghai, China; 2 Fudan University affiliated Huashan Hospital,
Shanghai, China; 3 Wayne State University, United States
In this study, susceptibility weighted imaging has been extended from human brain to abdomen for iron deposition research of hepatic diseases. From the
inital result, susceptibility weighted imaging could correlate the degree of hepatic iron overloaded of patients with their clinical examination results well. It
seems that susceptibility weighted imaging will be a promising method alternative to conventional T2, T2star methods for iron deposition research.
2607. T1_rho Dispersion MR Imaging for the Diagnosis and Characetrizaton of Different Liver Pathologies
Dania Daye 1 , Kejia Cai 2 , Mohammad Haris 2 , Anup Singh 2 , Santosh Gaddam 2 , Rebecca Wells 3,4 , Emma
Furth, Ravinder Reddy 2
1 Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States; 2 Department of Radiology, University of
Pennsylvania, Philadelphia, PA, United States; 3 Department of Medicine, University of Pennsylvania, Philadelphia, PA; 4 Department
of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States
It has been previously shown that T1ρ weighted MR imaging has significant potential to provide for a non-invasive assessment of liver disease, specifically
in fibrosis. In T1ρ weighted imaging, nuclear spins are locked with a radiofrequency locking field, yielding a longitudinal relaxation time (T1ρ) in the
rotating frame. By varying the strength of the locking field (B1), it is possible to make the T1ρ relaxation time changes sensitive to different contrast
mechanisms in tissues. Here, we show that that T1 ρ dispersion technique has significant potential to differentiate between different liver pathologies as well
al further characterize certain pathologies, such as fibrosis.
2608. Quantitative Assessment of Iron Overload in Liver of Patients with Thalassemia Major Using Ultra-
Short T2*
azza abdelrahim ahmed 1 , Taigang He 2 , Dudley Pennell 2 , David Firmin 2
1 CMR, imperial college london, London, Kensignton and Chelsea, United Kingdom; 2 Imperial college london
Attempts were made in measuring ultra-short T2*(