TRADITIONAL POSTER - ismrm

Poster Sessions
increase in cerebral blood flow (CBF) in the occipital region, and the increase was in accordance with literature values. In other areas of the brain, CBF
remained unchanged. Cerebral blood volume was also measured, but the increase observed was not found to be significant.
1732. Effects of Fat Saturation on Perfusion Parameter Quantifications for the Parotid Glands in Dynamic
Contrast-Enhanced MRI
Su-Chin Chiu 1,2 , Chun-Juan Juan 2 , Hsiao-Wen Chung 1,2 , Cheng-Chieh Cheng 1,2 , Hing-Chiu Chang, 1,3 ,
Hui-Chu Chiu 4,5 , Cheng-Hsien Hsu 2,6 , Cheng-Yu Chen 2 , Guo-Shu Huang 2
1 Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; 2 Department of Radiology, Tri-Service
General Hospital, Taipei, Taiwan; 3 Applied Science Laboratory, GE Healthcare, Taipei, China; 4 Department of Nuclear Medicine, Tri-
Service General Hospital, Taipei, Taiwan; 5 EMBA in Global Chinese Management, Tamkang University, Taiwan; 6 Quanta Computer
Inc., Taipei
The effects of fat saturation on quantitative perfusion measurements using dynamic contrast-enhanced (DCE) MRI have not been documented for the parotid
glands. In this study we included phantom and in vivo studies to compare the relationship between fat content and the difference between perfusion
parameters derived from non-fat-saturated (NFS) and fat-saturated (FS) DCE-MRI. Significant differences were found for all amplitude-related parameters
in parotid glands but not for muscular tissue. It is suggested that the use of FS or NFS should be explicitly specified for objective comparison of perfusion
parameters with DCE-MRI on fat-containing tissues such as the parotid glands.
1733. Factors Affecting the Detection of Permeability Derangements in Perfusion Imaging of Stroke Patients
Richard Leigh 1 , Argye Elizabeth Hillis 2 , Peter B. Barker 3
1 Neurology, Johns Hopkins Univeristy School of Medicine, Towson, MD, United States; 2 Neurology, Johns Hopkins University
School of Medicine, Baltimore, MD, United States; 3 Radiology, Johns Hopkins Univeristy School of Medicine, Baltimore, MD,
United States
Detection of permeability derangements in stroke patients may help guide therapy and improve outcomes. PWI, which is routinely performed in stroke
imaging, can be used to assess permeability derangements through accumulation of contrast into the brain parenchyma. However it is unclear how the
recorded signal can be quantified and normalized across patients. We analyzed nine stroke patients with evidence of contrast leakage on PWI to see how
differences in acquisition parameters affected the recorded signal. We found that the measurements were greatly affected not only by the acquisition
parameters but also the tissue type from which the signal was recorded.
1734. Quantitative Analysis of Clinical Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-
MRI) to Evaluate Treatment Response in Human Breast Cancer
Yanming Yu 1,2 , Jun Li 1 , Quan Jiang 3 , Shanglian Bao 1 , Yi Zhong 4 , Yongquan Ye 2 , Jiong Zhu 5 , Yongming
Dai 6 , Ewart Mark Haacke 2 , Jiani Hu 2
1 Beijing key lab of medical physics and engineering, Peking University, Beijing, China; 2 Department of Radiology, Wayne State
University, Detroit, MI, United States; 3 Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI, United States; 4 4.
Sino-Dutch Biomedical & Information Engineering, Northeastern University, Shenyang, Liaoning, China; 5 Department of
Radiology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai; 6 Healthcare, Magnetic Resonance Imaging,
Siemens Ltd. China, Shenzhen, Guangdong, China
There are several practical limitations in quantitative analysis of clinical DCE-MRI for assessing treatment response, including: 1) difficulty in obtaining an
accurate arterial input function (AIF); 2) the long scanning time to accurately estimate baseline T1(0); and 3) often highly variable or unphysical results due
to noise effects; 4) long computational time. We develop a method that combines a fixed-T1, the Fuzzy C-Means and the reference region model to
overcome the aforementioned limitations in quantitative analysis of clinical DCE-MRI without measuring either an AIF or T1(0), and demonstrate its
feasibility to assess neoadjuvant chemotherapy for breast cancer using clinical DCE-MRI.
1735. Dual-Injection of a Low- And a Macro-Molecular-Weight-Contrast Media to Monitor the Blood-Brain
Barrier Status in a Glioma Model Under Therapy
Benjamin Lemasson 1,2 , Raphaël Serduc 3 , Cecile Maisin 1,4 , Audrey Bouchet 3 , Nicolas Coquery 1,4 , Philippe
Robert 5 , Christopoh Segebarth 1,4 , Géraldine Le Duc 3 , Irène Tropres 1,4 , Chantal Rémy 1,4 , Emmanuel Louis
Barbier 1,4
1 Inersm U836, Grenoble, France; 2 Oncodesign Biotechnology, Dijon, France; 3 ESRF, Grenoble, France; 4 Université Joseph Fourier,
Grenoble Institut des Neurosciences, Grenoble, France; 5 Guerbet Research, Aulnay-Sous-Bois, France
Numerous anti-tumor therapies modify the permeability (increase or decrease) of tumoral or healthy vessels. Permeability can be assessed by Dynamic
Contrast-Enhanced-MRI (DCE-MRI). Low- (0.5kDa) and macro (3.5kDa) -molecular-weight-CM, DCE-MRI was performed within the same imaging
session on 80 rats bearing 9L gliosarcoma before and three times after treatments onset (antiangiogenic and/or synchrotron radiotherapy), searching for
possible increase or decrease in vessel wall permeability. This study suggests that the choice of CM for a DCE-MRI depends on the physiological questions
to be addressed. It also suggests that the use of two CM within the same MRI session is feasible.