TRADITIONAL POSTER - ismrm

Poster Sessions
2666. Impact of Anti-Inflammatory Treatment on Placental and Neurodevelopmental Defects Monitored in
Utero by MRI
Sylvie Girard 1 , Luc Tremblay 2 , Guillaume Sebire 1 , Martin Lepage 2
1 Pediatric, Universite de Sherbrooke, Sherbrooke, Qc, Canada; 2 Radiobiology, Universite de Sherbrooke, Sherbrooke, Qc, Canada
Perinatal inflammation predominantly affects preterm newborns leading to brain damage. Interleukin-1 (pro-inflammatory molecule) appears to be a key
mediator linking maternal inflammation and fetal brain damage. Strategies to protect the fetal brain are currently unavailable mainly due to the lack of noninvasive
tools to detect in utero inflammation and monitor the impact of an anti-inflammatory treatment. We showed that MRI is a potent technique to
detect placental damage and can be used to monitor the impact of anti-inflammatory treatment in an animal model of prenatal inflammation.
2667. Assessment of Placental Morphology and Magnetic Resonance Imaging Biomarkers at 1.5 Tesla
David M. Morris 1,2 , Caroline Wright 3 , Philip N. Baker 4 , Ian P. Crocker 3 , Penny A. Gowland 5 , Geoff J.
Parker 1,2 , Colin P. Sibley 3
1 Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, University of Manchester, Manchester,
United Kingdom; 2 The University of Manchester Biomedical Imaging Insitute, University of Manchester, Manchester, United
Kingdom; 3 Maternal & Fetal Health Research Centre, University of Manchester, Manchester, United Kingdom; 4 Faculty of Medicine
& Dentistry, University of Alberta, Edmonton, Canada; 5 Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham,
Nottingham, United Kingdom
Fetal growth retardation (FGR) is a serious condition affecting babies in utero that can be identified by means of a placental phenotype related to structural
and functional changes in the placenta. Magnetic resonance imaging (MRI) measured the relaxation times T 1 and T 2 as possible biomarkers of this condition
and placentas were collected for the histological verification of FGR pathology. We show for the first time that both in utero T 1 and T 2 demonstrate a
significant negative correlation with the gestational age at 1.5 T and that relaxation times correlate with histological biomarkers of placental development.
2668. T1-Weighted Imaging of Fetal Microcolon
Erika Rubesova 1 , James Gilmore 1 , Shreyas Vasanawala 1 , Richard A. Barth 1
1 Pediatric Radiology, Lucile Packard Children's Hospital at Stanford, Stanford, CA, United States
T1-weighted images allow visualisation of the fetal colon. Microcolon is important to recognize since it aids to accurate diagnosis in patients referred for
fetal MRI with gastrointestinal abnormalities. In our retrospective study, we reviewed the T1-weighted images in fetuses with microcolon and tried to define
the optimal plane andsequence (FGRE versus 3D dual-echo SPGR) for evaluation of the microcolon.
2669. Using DCE-MRI to Determine Vascular Properties of Female Rhesus Macaque Reproductive Tissue:
Pharmacokinetic Model Considerations
Ian J. Tagge 1 , Cecily V. Bishop 2 , Richard L. Stouffer 2,3 , Charles S. Springer, Jr. 1 , Xin Li 1
1 Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States; 2 Division of Reproductive
Sciences, ONPRC, Oregon Health & Science University; 3 Department of Obstetrics and Gynecology, Oregon Health & Science
University
The female uterus and ovary are among the few normal tissues to undergo periodic angiogenic changes. Using a primate model (rhesus macaque), we
investigate the feasibility of DCE-MRI to quantify blood volume fraction (vb) and contrast reagent (CR) transendothelial permeability. The standard model
with vb (SM2) and the second generation “shutter-speed” model (SSM2), are used in parallel for this effort.
2670. Determining the Utility of Pre-Treatment MRI Data in Predicting the Survival Interval of Patients
Diagnosed with Carcinoma of the Cervix Treated with Chemoradiotherapy
Martin D. Pickles 1 , Sue Booth 2 , Lindsay W. Turnbull 1
1 Centre for MR Investigations, University of Hull, Hull, East Yorkshire, United Kingdom; 2 Institue of Oncology, St James' Hospital,
Leeds, West Yorkshire, United Kingdom
Chemoradiotherapy in combination with brachytherapy has become the standard treatment for advanced cervical carcinomas. Although the intent of the
treatment is curative a significant number of patients do not survive beyond 5 years. Consequently, biomarkers of reduced survival intervals are currently
being sought. The aim of this work was to determine if any of the studied MR derived parameters were associated with longer disease free and/or overall
survival. This study demonstrated that for this cohort the MR derived stage (FIGO or TNM) based on morphological assessment of the disease present
provided the most significant association with survival intervals.
2671. Pelvic B1 Mapping at 3T for DCE
Rexford D. Newbould 1 , Brandon Whitcher 1
1 GSK Clinical Imaging Centre, London, United Kingdom
Dynamic contrast enhanced perfusion measurement (DCE) is hampered in the body at higher field strengths such as 3T by the large spread of achieved
flipangles across the volume of interest. In DCE, it is common to measure the change in voxel T1 using a variable flipangle spoiled gradient echo sequence,
in order to quantify contrast agent concentration. The extreme variation in achieved flip angle at 3T in the body has precluded accurate quantification. Here,
B1 mapping using the saturated double angle method is performed rapidly in the same locations as the dynamic scan, in order to correctly estimate T1
values.