TRADITIONAL POSTER - ismrm

Poster Sessions
2100. A Voxel Based Diffusion Tensor Image Analysis on Cognitive Decline in Mildly and Moderately
Impaired Multiple Sclerosis Patients
Wim Van Hecke 1 , Jan Sijbers 2 , Alexander Leemans 3 , Guy Nagels 4 , Evert Vandervliet 1 , Paul M. Parizel 1
1 Department of Radiology, Antwerp University Hospital, Antwerp, Belgium; 2 VisionLab, University of Antwerp, Antwerp, Belgium;
3 Image Sciences Institute, Utrecht, Netherlands; 4 MS centrum, Melsbroek, Belgium
The aim of this study was to examine the relationship between the Paced Auditory Serial Addition Test and the diffusion properties that are related to
microstructural white matter breakdown in patients with mild and moderate Multiple Sclerosis.
2101. Early Compensatory Changes Within the Memory Network of Multiple Sclerosis Patients
Hanneke E. Hulst 1 , Stefan D. Roosendaal 1 , Menno M. Schoonheim 1 , Lizanne J. Schweren 1 , Ysbrand D. van
der Werf 2 , Chris H. Polman 3 , Frederik Barkhof 1 , Jeroen J. Geurts 1,4
1 Radiology, VU University Medical Center, Amsterdam, Noord-Holland, Netherlands; 2 Clinical Neurophysiology, VU University
Medical Center, Amsterdam, Noord-Holland, Netherlands; 3 Neurology, VU University Medical Center, Amsterdam, Noord-Holland,
Netherlands; 4 Pathology, VU University Medical Center , Amsterdam, Noord-Holland, Netherlands
Cognitive decline is frequently seen in multiple sclerosis (MS). This study investigates the changes in hippocampal activation patterns in MS. Functional
MRI, an encoding- and retrieval paradigm, was acquired of 24 cognitively preserved (CP) and 10 cognitively impaired (CI) MS patients and 15 healthy
controls (HC). Where CP patients only showed increased brain activation in the dorsal streams of the memory system, CI patients showed reduced brain
activation in the (para)hippocampal areas and the ventral stream of the memory system. Our findings indicate that functional reorganization takes place early
in the disease course and is a finite phenomenon in MS.
2102. Memory Impairment in MS Correlates to Hemodynamic Response in Event-Related FMRI of
Incidental Encoding
Katherine A. Koenig 1 , Blessy Mathew 1 , Jian Lin 1 , Lael Stone 2 , Stephen Rao 3 , Michael Phillips 1 , Mark J.
Lowe 1
1 Imaging Institute, The Cleveland Clinic, Cleveland, OH, United States; 2 Mellen Center, The Cleveland Clinic, Cleveland, OH, United
States; 3 Schey Center, The Cleveland Clinic, Cleveland, OH, United States
Eighteen patients with MS performed a verbal incidental encoding task, followed by a word recognition task. Performance on the WR task was used to split
incidental encoding stimuli into “encoded” and “non-encoded” maps. The fit hemodynamic response amplitude during encoded and non-encoded stimuli on
the encoding task was correlated with a test of verbal memory. Against expectation, the non-encoded words showed only positive correlations, while the
encoded words showed only negative correlations with verbal memory performance. It is unclear if this result is due to disease processes in MS, or due to
compensatory strategies.
2103. Cognitive Impairment in Early Multiple Sclerosis Related to Metabolic Impairment in Cerebellum
Wafaa Zaaraoui 1 , Françoise Reuter 1 , Audrey Rico 1 , Irina Malikova 1 , Elisabeth Soulier 1 , Patrick Viout 1 ,
Yann Le Fur 1 , Sylviane Confort-Gouny 1 , Patrick J. Cozzone 1 , Jean Pelletier 1 , Jean-Philippe Ranjeva 1 ,
Bertrand Audoin 1
1 Faculté de Médecine, CRMBM UMR CNRS 6612, Marseille, France
While metabolic changes and cognitive impairment are known to be present in multiple sclerosis (MS) from the earliest stage of the disease, no exhaustive
examinations have been performed to assess potential relationships between metabolite levels and cognitive status. Our study aimed to investigate whether
magnetic resonance spectroscopic markers in normal appearing brain tissues are related to cognitive status in multiple sclerosis.
2104. Is Myelin Water Fraction a Clinically Viable Biomarker of Disease in Primary Progressive Multiple
Sclerosis?
Shannon Kolind 1,2 , Lucy Matthews 1,3 , Heidi Johansen-Berg 1 , Rose Gelineau-Kattner 1,4 , M Isabel Leite 3 ,
Jacqueline Palace 3 , Sean Deoni 2
1 FMRIB Centre, University of Oxford, Oxford, United Kingdom; 2 Centre for Neuroimaging Sciences, King's College London,
London, United Kingdom; 3 Clinical Neurology, Oxford University and Oxford Radcliffe Hospitals NHS Trust, Oxford, United
Kingdom; 4 Baylor College of Medicine, Houston, TX, United States
Critical need exists for a sensitive and specific biomarker in primary progressive multiple sclerosis (PPMS), which features diffuse neuronal and myelin
damage. This study explored estimates of myelin water fraction (MWF) as such a biomarker. Sixteen PPMS patients were imaged using the mcDESPOT
multi-component relaxometry technique, and correlations between MWF estimates and clinical disability scores were investigated. We found significant
negative correlation between MWF and EDSS scores across diffuse brain regions. Correlations between MWF and specific scores of bladder/bowel, mental
and sensory functions were found in appropriate brain regions. Findings support the emerging relevance of MWF changes to clinical manifestations.
2105. Preparation for Multi-Site Myelin Water Relaxation Studies: Inter and Intra-Site Reproducibility in
Normal Controls
Cornelia Laule 1,2 , Irene M. Vavasour 1 , Burkhard Mädler 2 , Trudy Harris 3 , David KB Li 1 , Anthony L.
Traboulsee 4 , Alex L. MacKay 1,2
1 Radiology, University of British Columbia, Vancouver, BC, Canada; 2 Physics & Astronomy, University of British Columbia,
Vancouver, BC, Canada; 3 UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada; 4 Medicine,
University of British Columbia, Vancouver, BC, Canada
Quantitative assessment of T 1 and T 2 relaxation has the potential to provide important in-vivo markers for disease progression and treatment efficacy in
pharmaceutical trials. The present study examine cross-site reproducibility of mean T 1 , geometric mean T 2 (GMT 2 ) and myelin water fraction (MWF)
measured on the same 5 people at 6 sites. Average percent differences of inter and intra-site reproducibility was