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Poster Sessions<br />

2100. A Voxel Based Diffusion Tensor Image Analysis on Cognitive Decline in Mildly and Moderately<br />

Impaired Multiple Sclerosis Patients<br />

Wim Van Hecke 1 , Jan Sijbers 2 , Alexander Leemans 3 , Guy Nagels 4 , Evert Vandervliet 1 , Paul M. Parizel 1<br />

1 Department of Radiology, Antwerp University Hospital, Antwerp, Belgium; 2 VisionLab, University of Antwerp, Antwerp, Belgium;<br />

3 Image Sciences Institute, Utrecht, Netherlands; 4 MS centrum, Melsbroek, Belgium<br />

The aim of this study was to examine the relationship between the Paced Auditory Serial Addition Test and the diffusion properties that are related to<br />

microstructural white matter breakdown in patients with mild and moderate Multiple Sclerosis.<br />

2101. Early Compensatory Changes Within the Memory Network of Multiple Sclerosis Patients<br />

Hanneke E. Hulst 1 , Stefan D. Roosendaal 1 , Menno M. Schoonheim 1 , Lizanne J. Schweren 1 , Ysbrand D. van<br />

der Werf 2 , Chris H. Polman 3 , Frederik Barkhof 1 , Jeroen J. Geurts 1,4<br />

1 Radiology, VU University Medical Center, Amsterdam, Noord-Holland, Netherlands; 2 Clinical Neurophysiology, VU University<br />

Medical Center, Amsterdam, Noord-Holland, Netherlands; 3 Neurology, VU University Medical Center, Amsterdam, Noord-Holland,<br />

Netherlands; 4 Pathology, VU University Medical Center , Amsterdam, Noord-Holland, Netherlands<br />

Cognitive decline is frequently seen in multiple sclerosis (MS). This study investigates the changes in hippocampal activation patterns in MS. Functional<br />

MRI, an encoding- and retrieval paradigm, was acquired of 24 cognitively preserved (CP) and 10 cognitively impaired (CI) MS patients and 15 healthy<br />

controls (HC). Where CP patients only showed increased brain activation in the dorsal streams of the memory system, CI patients showed reduced brain<br />

activation in the (para)hippocampal areas and the ventral stream of the memory system. Our findings indicate that functional reorganization takes place early<br />

in the disease course and is a finite phenomenon in MS.<br />

2102. Memory Impairment in MS Correlates to Hemodynamic Response in Event-Related FMRI of<br />

Incidental Encoding<br />

Katherine A. Koenig 1 , Blessy Mathew 1 , Jian Lin 1 , Lael Stone 2 , Stephen Rao 3 , Michael Phillips 1 , Mark J.<br />

Lowe 1<br />

1 Imaging Institute, The Cleveland Clinic, Cleveland, OH, United States; 2 Mellen Center, The Cleveland Clinic, Cleveland, OH, United<br />

States; 3 Schey Center, The Cleveland Clinic, Cleveland, OH, United States<br />

Eighteen patients with MS performed a verbal incidental encoding task, followed by a word recognition task. Performance on the WR task was used to split<br />

incidental encoding stimuli into “encoded” and “non-encoded” maps. The fit hemodynamic response amplitude during encoded and non-encoded stimuli on<br />

the encoding task was correlated with a test of verbal memory. Against expectation, the non-encoded words showed only positive correlations, while the<br />

encoded words showed only negative correlations with verbal memory performance. It is unclear if this result is due to disease processes in MS, or due to<br />

compensatory strategies.<br />

2103. Cognitive Impairment in Early Multiple Sclerosis Related to Metabolic Impairment in Cerebellum<br />

Wafaa Zaaraoui 1 , Françoise Reuter 1 , Audrey Rico 1 , Irina Malikova 1 , Elisabeth Soulier 1 , Patrick Viout 1 ,<br />

Yann Le Fur 1 , Sylviane Confort-Gouny 1 , Patrick J. Cozzone 1 , Jean Pelletier 1 , Jean-Philippe Ranjeva 1 ,<br />

Bertrand Audoin 1<br />

1 Faculté de Médecine, CRMBM UMR CNRS 6612, Marseille, France<br />

While metabolic changes and cognitive impairment are known to be present in multiple sclerosis (MS) from the earliest stage of the disease, no exhaustive<br />

examinations have been performed to assess potential relationships between metabolite levels and cognitive status. Our study aimed to investigate whether<br />

magnetic resonance spectroscopic markers in normal appearing brain tissues are related to cognitive status in multiple sclerosis.<br />

2104. Is Myelin Water Fraction a Clinically Viable Biomarker of Disease in Primary Progressive Multiple<br />

Sclerosis?<br />

Shannon Kolind 1,2 , Lucy Matthews 1,3 , Heidi Johansen-Berg 1 , Rose Gelineau-Kattner 1,4 , M Isabel Leite 3 ,<br />

Jacqueline Palace 3 , Sean Deoni 2<br />

1 FMRIB Centre, University of Oxford, Oxford, United Kingdom; 2 Centre for Neuroimaging Sciences, King's College London,<br />

London, United Kingdom; 3 Clinical Neurology, Oxford University and Oxford Radcliffe Hospitals NHS Trust, Oxford, United<br />

Kingdom; 4 Baylor College of Medicine, Houston, TX, United States<br />

Critical need exists for a sensitive and specific biomarker in primary progressive multiple sclerosis (PPMS), which features diffuse neuronal and myelin<br />

damage. This study explored estimates of myelin water fraction (MWF) as such a biomarker. Sixteen PPMS patients were imaged using the mcDESPOT<br />

multi-component relaxometry technique, and correlations between MWF estimates and clinical disability scores were investigated. We found significant<br />

negative correlation between MWF and EDSS scores across diffuse brain regions. Correlations between MWF and specific scores of bladder/bowel, mental<br />

and sensory functions were found in appropriate brain regions. Findings support the emerging relevance of MWF changes to clinical manifestations.<br />

2105. Preparation for Multi-Site Myelin Water Relaxation Studies: Inter and Intra-Site Reproducibility in<br />

Normal Controls<br />

Cornelia Laule 1,2 , Irene M. Vavasour 1 , Burkhard Mädler 2 , Trudy Harris 3 , David KB Li 1 , Anthony L.<br />

Traboulsee 4 , Alex L. MacKay 1,2<br />

1 Radiology, University of British Columbia, Vancouver, BC, Canada; 2 Physics & Astronomy, University of British Columbia,<br />

Vancouver, BC, Canada; 3 UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada; 4 Medicine,<br />

University of British Columbia, Vancouver, BC, Canada<br />

Quantitative assessment of T 1 and T 2 relaxation has the potential to provide important in-vivo markers for disease progression and treatment efficacy in<br />

pharmaceutical trials. The present study examine cross-site reproducibility of mean T 1 , geometric mean T 2 (GMT 2 ) and myelin water fraction (MWF)<br />

measured on the same 5 people at 6 sites. Average percent differences of inter and intra-site reproducibility was

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