TRADITIONAL POSTER - ismrm

Poster Sessions
Sainte-Justine, Université de Montréal, Montreal, Quebec, Canada; 4 Groupe de recherche sur le système nerveux central, Université de
Montréal, Montreal, Quebec, Canada
A new animal model has been developed to study the relation between cortical dysplasia, hyperthermic seizure (HS) and temporal lobe epilepsy (TLE). In
this study, volumetric MRI, T2-weighted signal intensity and PET were used to better understand the neurodevelopmental changes that occur after HS in a
predisposed brain and a possible link with the development of TLE. Our results suggest a causal relationship between a T2-weighted signal change resulting
from metabolism/vascularisation imbalance after HS and a consequent developmental delay of the hippocampus.
2373. Cerebral Blood Volume Mapping of Macro- And Microvasculature in Mouse Brain with 3D Gradient
Echo MRI
Valerio Zerbi 1 , Diane Jansen 1 , Andor Veltien 2 , Amanda Kiliaan 1 , Arend Heerschap 2
1 Anatomy, UMC St. Radboud, Nijmegen, Netherlands; 2 Radiology, UMC St. Radboud, Nijmegen, Netherlands
Impaired cerebral macro- and microvascular perfusion play an important role in the development of Alzheimer’s disease(AD). Here, a post-processing
method is evaluated to distinguish and quantify cerebral blood volume(CBV) in macro- and microvasculature with contrast-enhanced MRI in a transgenic
mouse model for AD. A comparison between steady-state CBV computations is presented, and histogram analysis is used to separate between vascular
compartments. Results showed a decrease in hippocampal microvascular CBV as consequence of aging and genotyping that is not visible without separation
of vascular compartments for macro- and microvasculature perfusion.
2374. Correlation of Fractional Anisotropy and Mean Diffusivity in Rhesus Monkey with Age and
Parkinson’s Disease
Megan P. Phillips 1 , David K. Powell 2 , Zhiming Zhang 3 , Richard Grondin 3 , Peter A. Hardy 3
1 Center for Biomedical Engineering, University of Kentucky, Lexington, KY, United States; 2 MRISC, University of Kentucky;
3 Anatomy and Neurobiology, University of Kentucky
Parkinson’s Disease (PD) is a common neurodegenerative disease characterized by loss of motor control. PD results from the loss of dopamine-producing
neurons in the substantia nigra (SN). Depletion of the dopamine neurons in the SN affects white matter tracts connecting the SN to the putamen. Using
diffusion tensor imaging (DTI) , the goals of our research are first to identify the white matter tracts between the SN and putamen effected by the depletion
of dopamine and second, identify the effects of age on white matter, specifically, fractional anisotropy (FA) and mean diffusivity (MD).
2375. Evaluation of Inflammatory Process in Parkinson's Disease Model: Magnetization Transfer Image
Histogram Parameter and 1H Magnetic Resonance Spectroscopy
Moon-Hyun Yoon 1 , Hyun-Jin Kim 2 , Jin-Yeung Jang 2 , Bo-Young Choe 1
1 Biomedical Engineering, Medical College, The Catholic Univ. of Korea, Seoul, Metro of Seoul, Korea, Republic of; 2 Lee Gil Ya
Cancer and Diabetes Institute, GACHON University of medicine and Science, Seoul, Korea, Republic of
We found that inflammatory process was significantly associated with the highest peak height value of MTR histogram in the striatum and the SN. A
possible explanation for this could be the early phase of the influence of specific neurotransmitters on the mean MTR values. The higher peak height of the
MTR histogram in the striatum and SN was significantly associated with higher Glx/Cr ratios after MPTP intoxication suggesting neuronal dysfunction. The
pathological studies in PD model clearly demonstrate the presence of disseminated activated microglial-like inflammatory cells in the central nervous
system.
2376. Longitudinal Magnetic Resonance Spectroscopy and T2 Measurements in a Mouse Model of Niemann-
Pick Type C Disease
John Totenhagen 1 , Ivan Borbon 2 , Eriko Yoshimaru 1 , Christine Howison 3 , Robert P. Erickson 2 , Theodore P.
Trouard 1
1 Biomedical Engineering, University of Arizona, Tucson, AZ, United States; 2 Pediatrics, University of Arizona, Tucson, AZ, United
States; 3 Arizona Research Laboratories, University of Arizona, Tucson, AZ, United States
Results are presented from a longitudinal study of T2 and MRS measurements in a mouse model of Niemann-Pick Type C (NPC) disease to examine T2
measurements and MRS as possible indicators of disease progression and response to therapy in NPC disease.
2377. Sub-Type Specific Hippocampal Glutamate Levels in the Chronic Mild Stress Rat Model for
Depression
Adriaan Campo 1 , Ove Wiborg 2 , Helene Benveniste 3 , Annemie Van Der Linden 1
1 Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium; 2 Center for psykiatrisk forskning, Århus Universitetshospital Risskov,
Risskov, Århus, Denmark; 3 Medical Department, Brookhaven National Laboratory, Upton, NY, United States
MR spectroscopy was used to assess neurochemical changes in the hippocampus of the CMS rat model for depression. Besides the well known anhedonic
phenotype, and control animals, a third group of animals was included: so-called stress resilient animals. These animals show different symptoms when
subjected to prolonged stress. We suppose that these different sings of depression are due to different modulation of the HPA axis, as assessed by glutamate
levels in the hippocampus: normal stressed animals show higher glutamate concentration, while the abnormal subgroup shows similar glutamate
concentration as the control animals.