TRADITIONAL POSTER - ismrm

Poster Sessions
1942. Cerebral Blood Flow in Alzheimer's Disease by Arterial Spin Labeling QUASAR
HKF Mak 1 , Queenie Chan 2 , Zhipeng Zhang 1 , Esben Petersen 3 , Deqiang Qiu 1 , Xavier Golay 4 , Leung-Wing
Chu 5
1 Diagnostic Radiology, University of Hong Kong, Hong Kong, Hong Kong; 2 Philips Healthcare; 3 Clinical Imaging Research Centre,
National University of Singapore, Singapore, Singapore; 4 UCL Institute of Neurology, Univeristy College of London, United
Kingdom; 5 Medicine, University of Hong Kong, Hong Kong
Arterial Spin Labeling MRI is a non-invasive method in studying cerebral blood flow, which can be used as an indirect marker of glucose metabolism. In our
local Chinese cohort of 13 Alzheimer's disease (mean age- 76.3, MMSE- 16.3) and 15 cognitively normal elderly adults (mean age- 70.8, MMSE- 28.4),
QUASAR sequence showed impaired cerebral blood flow in middle & posterior cingulate, bilateral inferior frontal, bilateral superior frontal, right inferior
parietal and left superior temporal gyri in AD as compared to controls. This distribution of perfusion impairment is characteristic of moderate Alzheimer’s
disease, analogous to regional hypometabolism in Positron Emission Tomography.
1943. Co-Analysis of Structural Imaging and DTI in Alzheimer's Disease
Valerie A. Cardenas 1,2 , Duygu Tosun 1,2 , Kristine Yaffe, 2,3 , Bruce Miller 4 , Norbert Schuff 1,2 , Michael W.
Weiner 1,2
1 Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States; 2 San Francisco VA, San Francisco, CA, United States;
3 Neurology and Psychiatry, UCSF, San Francisco, CA, United States; 4 Memory and Aging Clinic, UCSF, San Francisco, CA, United
States
A voxel-wise co-analysis of structural imaging and DTI is presented and compared to analyses with a single modality only, to determine whether a multimodality
analysis detects effects due to Alzheimer's disease with greater sensitivity. Results show that co-analysis with FA does not detect greater ADrelated
disease than structural analysis alone.
1944. Parental History of Alzheimer Disease Predicts Abnormal White Matter in Cognitively Normal Elderly
Individuals
Joseph Mettenburg 1 , David N. Daniels 1 , Beau Ances 2 , Huiling Peng 2 , Joshua Shimony 1 , Abraham Z.
Snyder 1 , John C. Morris 2 , Mark A. Mintun 1 , Tammie L.S. Benzinger 3
1 Mallinckrodt Institute of Radiology, Washington University in Saint Louis; 2 Neurology, Washington University in Saint Louis;
3 Mallinckrodt Institute of Radiology, Washington University in Saint Louis, St. Louis, MO, United States
DT-MRI was performed on cognitively normal adults with and without a family history of dementia of the Alzheimer’s type (DAT). Regional differences
were identified in the corpus callosum and parietal white matter in those individuals with confirmed parental history of DAT. These findings support the
hypothesis that white matter abnormalities precede the clinically apparent onset of dementia, representing either early pathophysiological changes or
fundamental differences in white matter integrity which may place individuals at risk for subsequent development of Alzheimer Disease.
1945. Discrimination of Alzheimer’s Disease from Cognitively Healthy Individuals: An Arterial Spin
Labeling MRI Study
Mike P. Wattjes 1 , Nelleke Tolboom 2 , Menno Schoonheim 1 , Jose Maria Garcia-Santos 1 , Joost P. Kuijer 1 ,
Bart N. M. van Berckel 3 , Philip Scheltens 2 , Frederik Barkhof 1 , Ernesto J. Sanz-Arigita 1
1 Dept. of Radiology, VU University Medical Center, Amsterdam, Netherlands; 2 Dept. of Neurology, VU University Medical Center;
3 Dept. of Nuclear Medicine, VU University Medical Center
These specific perfusion patterns measured by ASL-MRI suggest fundamental differences in the brain perfusion between AD patients and cognitively
healthy subjects and could contribution to the diagnoses of AD-related dementia.
1946. Resting State Functional Patterns in AD and Their Correlation with Regional Amyloid-β Distribution.
Ernesto Sanz-Arigita 1 , Nelleke Tolboom 2 , Jolanda Boverhoff 2 , A.A. Lammertsma 2 , R. Boellaard 2 , M.
Yaqub 2 , A.D. Windhorst 2 , Cornelius S. Stam 3 , Philip Scheltens 4 , Frederik Barkhof 5 , Bart van Berckel 2
1 Radiology, VUmc, Amsterdam, North Holland, Netherlands; 2 Nuclear Medicine and PET Research, VUmc, Amsterdam,
Netherlands; 3 Neurophysiology, VUmc, Amsterdam, Netherlands; 4 Neurology, VUmc, Amsterdam, Netherlands; 5 Radiology, VUmc,
Amsterdam, Netherlands
Alzheimer-related differences in basal functional brain networks are likely be related to the regional distribution of neuropathology. To explore this
relationship, we have scanned the same population of AD patients and age-matched controls both with fMRI in resting state condition and PET, employing
two different amyloid-b tracers: 11C-PIB reveals the distribution of neurofibrillary tangles and 18F-FDDNP binds predominantly to amyloid plaques. The
functional networks affected in AD, and the distribution of neuropathology largely overlaps. We will demonstrate the specific relationship between either
type of amyloid pathology and particular functional networks.
1947. Pulsed Arterial Spin Labeling Perfusion in Healthy Aging and Early Dementia
Christine Preibisch 1 , Annette Förschler 1 , Afra Wohlschläger 1 , Christian Sorg 2 , Timo Grimmer 2 , Hans
Förstl 2 , Alexander Kurz 2 , Claus Zimmer 1 , Panagiotis Alexopoulos 2
1 Abteilung für Neuroradiologie, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany; 2 Klinik und
Poliklinik für Psychiatrie und Psychotherapie, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany
Problem: PASL was used to study cerebral perfusion changes in patients with MCI and AD. Methods: Resting CBF maps were obtained from 16 young
(30±10a) and 15 elderly (65±5a) cognitively normal controls, 13 patients with MCI (69±9a) and 7 patients with mild dementia in AD (70.9±11.2a). Results:
Hypoperfusion was detected in parietal cortex and right angular gyrus when patients were compared to controls. A significant perfusion decrease in parietal
cortex and left caudate was also detected in elderly compared to young controls. Conclusion: This suggests that PASL is capable to investigate the transition
from normal ageing to dementia.