TRADITIONAL POSTER - ismrm

Poster Sessions
good visualization of micro-calcifications using a proton density weighted ultra-short TE MRI sequence with radial reconstruction. Ultra-short TE MRI has
potential for detection of mammographically visualized micro-calcifications.
2490. Distinguishing Molecular Subtypes of Breast Cancer Based on Computer-Aided Diagnosis of DCE-
MRI
Shannon Agner 1 , Mark Rosen 2 , Sarah Englander 2 , Diana Sobers 1 , Kathleen Thomas 2 , John Tomaszewski 3 ,
Michael Feldman 3 , Shridar Ganesan 1 , Mitchell Schnall 2 , Anant Madabhushi 1
1 Biomedical Engineering, Rutgers University, Piscataway, NJ, United States; 2 Radiology, University of Pennsylvania, Philadelphia,
PA, United States; 3 Pathology, University of Pennsylvania, Philadelphia, PA, United States
Previous studies based on visual inspection of breast tumors suggest that molecular subtypes of breast cancer are associated with distinct imaging
phenotypes on DCE-MRI. In this study, we develop a computer-aided diagnosis tool that utilizes textural kinetics, an attribute that captures time related
changes in internal lesion texture, to distinguish between 20 triple negative (estrogen receptor (ER) negative/ progesterone receptor (PR) negative/ human
epidermal growth factor (HER2) receptor negative) and 21 ER positive tumors. Our CAD system was found to outperform classifiers that were driven by
morphology, signal intensity kinetics, peak contrast texture, and pharmacokinetic parameters.
2491. Improved 3D MR Imaging Using Virtual Coil Deconvolution for Effective Density Weighted Imaging
(VIDED)
Marcel Gutberlet 1 , Anne Roth 1 , Dietbert Hahn 1 , Herbert Köstler 1
1 Institut fuer Roentgendiagnostik, University of Wuerzburg, Wuerzburg, Bavaria, Germany
A novel method is presented allowing improving 3D-MRI. Virtual coil deconvolution imaging for effective density weighted imaging (VIDED) combines
the virtual coil concept with density weighted imaging. DW imaging allows improving the spatial response function at an optimal signal-to-noise ratio but at
the expense of incoherent aliasing. In VIDED imaging this aliasing is suppressed by virtual coil deconvolution imaging which is a method allowing parallel
imaging even for single receiver coils. VIDED imaging was applied in slice direction of 3D-MRI improving the slice profile, increasing the SNR up to 17%
and the FOV in slice direction approximately by 25%.
2492. Saturation-Recovery Snapshot FLASH Reduces RF Pulse Angle Inhomogeneity Artefacts in DCE-MRI
of the Breast at 3T.
Che A. Azlan 1,2 , Trevor S. Ahearn 1 , Pierluigi Di Giovanni 1 , Scott I.K. Semple 3 , Fiona J. Gilbert 1 , Thomas
W. Redpath 1
1 Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, Scotland, United Kingdom; 2 Department of Biomedical
Imaging, University of Malaya, Kuala Lumpur, Malaysia; 3 Department of Medical Physics, University of Edinburgh, Edinburgh,
Scotland, United Kingdom
The objective of this study was to evaluate the effectiveness of Hoffmann's method of saturation-recovery snapshot FLASH (SRSF) to minimise the effect of
radiofrequency (RF) pulse angle inhomogeneity in breast dynamic contrast-enhanced (DCE)-MRI at 3T. We employed computer simulation and experiment
on gel phantom for this purpose. The simulation shows that Hoffmann’s SRSF produces a robust saturation in the presence of expected RF inhomogeneity.
The enhancement ratio data acquired broadly matches the simulation. Implementing this method may be a solution to minimise the effects of RF pulse angle
inhomogeneity in DCE-MRI of the breast at 3T.
2493. Patient-Specific Calibration for Breast MRI: Breast-Coil Insertable Reference Phantom
Marieke Heisen 1 , Bo Peng 2 , Abbie Marie Wood 3 , Devkumar Mustafi 2,3 , Johannes Buurman 4 , Gillian M.
Newstead 3 , Gregory S. Karczmar 3
1 Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 2 Biochemistry & Molecular Biology, The
University of Chicago, Chicago, IL, United States; 3 Radiology, The University of Chicago, Chicago, IL, United States; 4 Healthcare
Informatics, Philips Healthcare, Best, Netherlands
A unique calibration phantom was designed for routine use in breast MRI. It was used to correct the variable flip angles in a precontrast T1-measurement,
and to inspect T1 sensitivity in the clinically employed T1-weighted dynamic contrast-enhanced protocol. The flip angle correction altered the T1 estimates
in breast tissue significantly. The clinical protocol demonstrated an increase in signal intensity for decreasing T1 (as expected) until a certain level, after
which signal attenuation occurred. The quality of the breast images acquired with the phantom in place was found to be normal by an experienced
mammographer.
2494. MR Imaging Features of Invasive Lobular Carcinoma: A Comparison with Invasive Ductal Carcinoma
Sung Hun Kim 1 , Jae Young Byun 1 , Eun Suk Cha 1 , Hyun Sook Kim 1 , Jae Jeong Choi 1
1 Radiology, College of Medicine, the Catholic University of Korea, Seocho gu, Seoul, Korea, Republic of
Invasive lobular carcinoma (ILC) is the second most common breast cancer after invasive ductal carcinoma (IDC). The incidence of ILC has continuously
increased probably due to hormone replacement therapy. There were little studies to compare the imaging findings of ILC and IDC according to BI-RADS.
The purposes of our study were to characterize the mammographic and MR imaing features of ILC and to compare these imaging features with those of IDC.
Furthermore, the multiplicity and MRI diagnostic accuracy to detect the multiplicity apart from the index mass were determined.
2495. BOLD Imaging of Compressed Breast Hemodynamics
Stefan Alexandru Carp 1 , Azma Mareyam 1 , Lawrence Wald 1 , David Alan Boas 1
1 Radiology, Massachusetts General Hospital, Charlestown, MA, United States
External compression induced hemodynamic changes in the breast have recently been investigated as potential biomarkers of breast cancer. Using fast
diffuse NIR spectroscopy our group has demonstrated the non-invasive estimation of breast tissue blood flow and oxygen consumption. Consequently, we
have designed an integrated MRI-optical breast compression platform for simultaneous acquisition of MR and optical images. MR scans provide structural
prior information for optical reconstructions, as well as hemodynamic (BOLD) images for cross-validation against optically measured deoxy-hemoglobin.