TRADITIONAL POSTER - ismrm

Poster Sessions
2288. Adaptive Changes in Response Inhibition BOLD Responses Following Antidepressant Treatment
Darragh Downey 1 , Karen Elizabeth Davies 1 , Shane McKie 2 , Gabriella Juhasz 2 , Ian Muir Anderson 2 , John
Francis William Deakin 2 , Stephen Ross Williams 1
1 Imaging Science and Biomedical Engineering, University of Manchester, Manchester, Lancashire, United Kingdom; 2 Neuroscience
and Psychiatry Unit, University of Manchester, Manchester, Lancashire, United Kingdom
We investigated adaptive changes in 5-HT signalling following sub-chronic antidepressant treatment in healthy controls performing a response inhibition
paradigm. 24 healthy volunteers were provided with 20mg citalopram or placebo for 11 days and tested with a behavioural inhibition task after 14 days
following a 3 day drug washout. Citalopram pre-treatment compared to placebo was associated with a reduced response bilaterally in the inferior frontal
gyrus and BOLD increases in the right middle frontal gyrus, mid cingulate, precuneus and posterior cingulate when inhibiting responses. These findings
suggest that chronic antidepressant treatment modifies 5-HT pathways involved in cognitive flexibility and inhibitory control.
2289. A Novel FMRI Task to Visualize Frontal Lobe Circuitry Associated with Transient Sadness
Leslie Baxter 1 , Ryan Smith 1 , Richard Fadok 1 , Michael Purcell 1 , Seban Liu 1 , Josef Debbins 1
1 Neuroimaging, Barrow Neurological Institute, Phoenix, AZ, United States
We developed a novel functional magnetic resonance imaging (fMRI) method designed to activate the subgenual anterior cingulate cortex (sACC) and other
frontal regions during transient sadness. We sought to develop a task that would show sufficient and specific activation in individuals to be useful as a
potential target for deep brain stimulation treatment (DBS).
2290. Trait Anxiety and Serotonin Transporter Polymorphism Influence Amygdala Activation as Measured
with FMRI During Fear Extinction at 3 T
Harald Kugel 1 , Christina Sehlmeyer 2,3 , Udo Dannlowski 2,3 , Sonja Schoening 2,3 , Martin Pyka 2,3 , Astrid
Veronika Rauch 2,3 , Katharina Domschke 2 , Bettina Pfleiderer 1 , Pienie Zwitserlood 4 , Walter Heindel 1 , Volker
Arolt 2 , Carsten Konrad 3,5
1 Dept. of Clinical Radiology, University of Muenster, Muenster, NRW, Germany; 2 Dept. of Psychiatry, University of Muenster,
Muenster, NRW, Germany; 3 Research Group 4, Interdisciplinary Center for Clinical Research (IZKF), University of Muenster,
Muenster, NRW, Germany; 4 Dept. of Psychology, University of Muenster, Muenster, NRW, Germany; 5 Dept. of Psychiatry,
University of Marburg, Marburg, HE, Germany
The effect of the serotonin transporter polymorphism 5-HTTLPR and trait anxiety on amygdala activation during fear conditioning and extinction was
investigated with fMRI. 32 volunteers were tested with a fear-conditioning paradigm, presenting neutral faces combined with an acoustic startle. Individual
trait anxiety was determined with the State Trait Anxiety Inventory (STAI). Evaluation showed that trait anxiety and 5-HTTLPR polymorphism did not
affect acquisition, but fear extinction. Trait anxious volunteers and carriers of the short s-allele showed less deactivation of the amygdala during extinction,
demonstrating that they react strongly to fear stimuli, and they can extinct fear reactions less easily.
2291. Functional Differences in Mental Rotation Between Men and Transsexual Patients Before and During
Hormone Therapy Studied with FMRI at 3 T
Harald Kugel 1 , Sonja Schoening 2,3 , Almut Engelien 2,3 , Anette Kersting 2 , Cornelia Roestel 2 , Pienie
Zwitserlood 4 , Wolfgang Lehmann 5 , Walter Heindel 1 , Volker Arolt 2 , Carsten Konrad 6,7
1 Dept. of Clinical Radiology, University of Muenster, Muenster, NRW, Germany; 2 Dept. of Psychiatry, University of Muenster,
Muenster, NRW, Germany; 3 Research Group 4, Interdisciplinary Center for Clinical Research (IZKF), University of Muenster,
Muenster, NRW, Germany; 4 Dept. of Psychology, University of Muenster, Muenster, NRW, Germany; 5 Dept. of Psychology,
University of Magdeburg, Magdeburg, ST, Germany; 6 Research Group 4, Interdisciplinary Center for Clinical Research (IZKF) ,
University of Muenster, Muenster, NRW, Germany; 7 Dept. of Psychiatry, University of Marburg, Marburg, HE, Germany
In order to investigate differences in neurobiological processes in patients with gender identity disorder, 11 male-to-female transsexual patients before, 11
patients during cross-sex hormone therapy, and 11 control males underwent fMRI while performing a sexually dimorph mental rotation paradigm. The
transsexual subjects showed less activation in the left parietal cortex (BA 40). Activation patterns different from controls, i.e. distinct from their biological
sex, did not change during hormonal treatment.
2292. Temporal Modulation in Connectivity Within the Salience Network in Autism Spectrum Disorder
Juha Nikkinen 1 , Jukka Rahko 2 , Tuomo Starck 1 , Jukka Remes 1 , Ahmed Abou Elseoud 1 , Irma Moilanen 2 ,
Osmo Tervonen 1 , Vesa Kiviniemi 1
1 Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland; 2 Department of Child Psychiatry, Oulu University
Hospital, Oulu, Finland
Temporal modulation in connectivity within the salience network (SN) has been investigated in autism spectrum disorder (ASD) utilizing group independent
component analysis (ICA). Using the ICA mixing matrix time courses, connectivity between the components including SN structures, anterior insula (AI)
and anterior cingulate cortex (ACC), was investigated. One IC was found to be focused at AI and ACC structure was shown to be detectable in two ICs,
ventral ACC and dorsal ACC. As a result we show that the temporal modulation in connectivity is altered in ASD between the AI and ventral ACC
components.