TRADITIONAL POSTER - ismrm

Poster Sessions
1953. Association of White Matter Hyperintensities with White Matter Changes in Alzheimer's Disease as
Studied by DTI
Liya Wang 1 , Felicia C. Goldstein 2 , Hui Mao 1
1 Radiology and Emory Center for Systems Imaging, Emory University School of Medicine, Atlanta, GA, United States; 2 Neurology,
Emory University School of Medicine, Atlanta, GA, United States
White matter hyperintensities (WMH) provide an additive effect is considered to be a risk factor of Alzheimer¡¯s disease (AD). We investigated which DTI
indices: fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (DR) and axial diffusivity (DX) values were more sensitive to differentiate AD
from normal control and how different levels of WMH may contribute to AD in specific areas of the white matter. FA and DR were helpful to discriminate
AD with different grade of WMH. Different level WMH contributed AD in different regions and extent. The increased DR may provide measurement of
demyelination of AD in pathology.
1954. Reduced Regional Fractional Anisotropy in Cognitively Normal Individuals with Biochemical and
Imaging Evidence of Cerebral Amyloid Deposition
Joseph Mettenburg 1 , David N. Daniels 1 , Yvette I. Sheline, 12 , Beau Ances 3 , Huiling Peng 3 , Abraham Z.
Snyder 1 , John C. Morris 3 , Mark A. Mintun 1 , Tammie L.S. Benzinger 4
1 Mallinckrodt Institute of Radiology, Washington University in Saint Louis; 2 Psychiatry, Washington University in Saint Louis;
3 Neurology, Washington University in Saint Louis; 4 Mallinckrodt Institute of Radiology, Washington University in Saint Louis, St.
Louis, MO, United States
Amyloid plaque deposition in the brain is one of the key pathological hallmarks of Alzheimer’s disease. Recently, CSF amyloid beta42 peptide levels and
PET scans using C-11 Pittsburgh Compound B (PIB) have been established as potential biomarkers for dementia of the Alzheimer’s type (DAT). Using
DTI, we evaluated white matter microstructure in subjects with and without established DAT and identified differences in both the corpus callosum and
precuneus. The same white matter findings were identified in non-demented subjects with positive CSF and PIB-PET, suggesting that microstructural
abnormalities in white matter integrity may precede cognitive changes in DAT.
1955. White Matter Disruption and Its Relationship with Cognitive Function and Cortical Atrophy in
Alzheimer’s Disease
Hao Huang 1 , Xin Fan 1 , Kristin Martin-Cook 2 , Guanghua Xiao 3 , Laura Lacritz 4 , Myron Weiner 4 , Roger
Rosenberg 2
1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2 Department of
Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States; 3 Department of Clinical Sciences,
University of Texas Southwestern Medical Center, Dallas, TX, United States; 4 Department of Psychiatry, University of Texas
Southwestern Medical Center, Dallas, TX, United States
The purpose of this study is to find an effective white matter biomarker of Alzheimer’s disease (AD) which may indicate disease severity and progression. In
this study, DTI and T1 weighted images were acquired from 38 subjects (20 AD, 18 controls). We surveyed all white matter tracts by labeling of the ICBM-
DTI-81 digital atlas and correlated FA values of individual white matter tracts with cognitive testing score and cortical atrophy map respectively. The
correlation analyses show that tracts in the limbic system, namely fornix and cingulum, are the most sensitive tract to cognitive testing scores and cortical
atrophy.
1956. Quantitative 7T Relaxographic, Volumetric and DCE Assessment of Thalamic Changes in Early
Alzheimer’s Disease
Valerie C. Anderson 1 , David P. Lenar 1 , Joseph F. Quinn 2 , William J. Woodward 3 , Jeffrey A. Kaye 2 ,
William D. Rooney 3
1 Neurological Surgery, Oregon Health & Science University, Portland, OR, United States; 2 Neurology, Oregon Health & Science
University, Portland, OR, United States; 3 Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR,
United States
Longitudinal water proton ( 1 H 2 O) relaxation time constants (T 1 ) are strongly associated with macromolecular volume fraction. Here, we report that 1 H 2 O T 1
values are increased in the thalamus of subjects with early AD compared to age-matched, cognitively normal controls. Further, we find that the increased
1 H 2 O T 1 values in early AD reflect, at least in part, neurodegenerative (macromolecular loss) processes and that contributions to the increased 1 H 2 O T 1
values from altered blood water content (via dilation or increased vessel density) are small.
1957. Dementia Induces Correlated Reductions in White Matter Integrity and Cortical Thickness: A
Multivariate Neuroimaging Study with Sparse Canonical Correlation Analysis
Brian Avants 1 , Phil Cook 1 , Lyle Ungar 1 , James Gee 1 , Murray Grossman 1
1 University of Pennsylvania, philadelphia, PA, United States
We present a novel, unsupervised method, sparse canonical correlation analysis for neuroimaging (SCCAN), that automatically locates correlated sets of
voxels in complementary imaging modalities. The method reveals significant and syndrome-specific cortical thickness-diffusion tensor imaging networks in
two neurodegenerative diseases, AD and FTD. Subject diagnosis was confirmed by autopsy or CSF-biomarker ratios. The SCCAN summary correlates, in
AD, with MMSE reduction and, in FTD, with reduced verbal fluency. Thus, SCCAN identifies disease-specific networks of effects in white matter and
cortical thickness that appear in anatomy suspected to be involved in these diseases and that relate specifically to impaired cognitive processes.