TRADITIONAL POSTER - ismrm

Poster Sessions
identification of a contrast filled needle sleeve with real-time adjustment of the scan prescription for continuous delineation of the needle trajectory during
manipulation was investigated in phantom and patients for MR-guidance of percutaneous procedures in a closed bore 1.5T clinical scanner.
1862. Targeted Magnetic Delivery of Cells with an MRI Scanner
Johannes Riegler 1,2 , Jack A. Wells 1 , Panagiotis Kyrtatos 1 , Anthony N. Price 1 , Mark F. Lythgoe 1
1 Centre for Advanced Biomedical Imaging (CABI), Department of Medicine and Institute of Child Health, University College London
(UCL), London, United Kingdom; 2 Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX),
UCL, London, United Kingdom
Targeted delivery of cells or drugs is a technique that could increase the efficacy of medical treatments. One possibility for that is using magnetic fields to
drag labelled entities to the site of interest. MRI systems are particular interesing for this purpose due to their ability to generate uniform magnetic field
gradients across the whole body. We demonstrated the feasibility of steering magnetically labelled cells to one exit tube of a bifurcation phantom by
applying MR imaging gradients. This technique could potentially be used for localised cell delivery in the vascular system.
1863. Simultaneous Wireless Fast Scan Cyclic Voltammetry and Amperometry with 3T MRI
Kendall Lee 1 , Jonathan Bledsoe 1 , Kiaran McGee 2 , John Huston 2 , Chris Kimble 3 , Filippo Agnesi, Kevin
Bennet 3 , Charles Blaha 4 , Paul Garris 5
1 Department of Neurosurgery, Mayo Clinic, Rochester, MN, United States; 2 Department of Radiology, Mayo Clinic, Rochester, MN,
United States; 3 Department of Engineering, Mayo Clinic, Rochester, MN, United States; 4 Department of Psychology, University of
Memphis; 5 Biological Sciences, Illinois State University
Electroanalytical techniques such as fast-scan cyclic votlammetry (FSCV) and constant-potential amperometry (CPA) have revolutionized neuroscience
research by supporting temporally, spatially, and chemically resolved neurotransmitter measurements in the brain. CPA and FSCV were performed by a
small, digital-telemetry device called a wireless instantaneous neurotransmitter concentration system (WINCS) specifically developed for neurochemical
monitoring. Test measurements were collected during simultaneous 3T imaging using a fast spin echo sequence. WINCS dynamically recorded dopamine
electrochemical signatures with sub-second temporal resolution and with high fidelity. We demonstrate proof-of-concept for combining WINCS real-time
neurochemical measurements and 3T MRI that may offer simultaneous neurochemical monitoring during fMRI.
1864. Two Channel Interventional Cervix Coil for High Dose Rate Brachytherapy
Nikolay Vladimirovic Viskusenko 1 , Emre Kopanoglu 2 , John Jezioranski 3 , Warren Foltz 3 , Oktay Algin 4 ,
Ergin Atalar 2
1 UMRAM: National Magnetic Resonance Research Center , Bilkent Universty Elektrical and Elektronic Engineering , Ankara ,
Turkey; 2 UMRAM: National Magnetic Resonance Research Center, Bilkent Universty Elektrical and Elektronic Engineering, Ankara,
Turkey; 3 University Health Network, Toronto, Canada; 4 Radiology, Ataturk Hospital, Ankara, Turkey
Determination of the diseased tissue region is very crucial for brachytherapy treatment. In this study, we propose a new 2-channel coil structure that is
embedded on a commercially available HDRT applicator. After MRI imaging of the cervix, brachytherapy procedure can be carried out as normal without
moving the applicator, which is essential for the correctness of radiation dose calculations. In-vivo animal experiments have been conducted and good
quality images have been obtained.
1865. Esophagus Imaging with Intraluminal RF Coil for Integrated MR-Endoscope System
Yuichiro Matsuoka 1 , Hayato Yoshinaka 1 , Susumu Aizawa 2 , Makiya Matsumoto 2 , Yoshinori Morita 1 ,
Hiromu Kutsumi 1 , Etsuko Kumamoto 3 , Kagayaki Kuroda 4,5 , Takeshi Azuma 1
1 Graduate School of Medicine, Kobe University, Kobe, Hyogo, Japan; 2 Graduate School of Engineering, Kobe University, Kobe,
Hyogo, Japan; 3 Information Science and Technology Center, Kobe University, Kobe, Hyogo, Japan; 4 Medical Device Development
Center, Foundation for Biomedical Research and Innovation, Kobe, Hyogo, Japan; 5 School of Information Science and Technology,
Tokai Univesity, Hiratsuka, Japan
An endoscope shows an interior surface image of organ, but it has difficulty finding the information under tissue surface. To assist endoscopy and
endoscopic surgery by providing cross-sectional images, we have developed an integrated MR-endoscope system. An intraluminal RF coil to be inserted into
esophagus was designed, and MR imaging using this coil and a tracking system to detect the coil position in MRI was conducted using an excised porcine
tissue. The layer structure in esophagus could be distinguished in T1- and T2-weighted images. The feasibility of esophagus imaging by the developed coil
having high Q value was demonstrated.
Cell Tracing
Hall B Tuesday 13:30-15:30
1866. Novel Perfluorooctylbromide Alginate Microcapsules for Enhanced Mesenchymal Stem Cells Survival
and Noninvasive Imaging Using Clinical CT and 19 F MRI
Yingli Fu 1 , Dorota A. Kedziorek 1 , Steven Shea 2 , Yibin Xie 1 , Ronald Ouwerkerk 3 , Gary Huang 1 , Tina
Ehtiati 2 , Steffi Valdeig 1 , Jeff WM Bulte 1,4 , Frank Wacker 1 , Dara Kraitchman 1
1 Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States; 2 Imaging and Visualization, Siemens
Corporate Research, Baltimore, MD, United States; 3 National Institute of Diabetes and Digestiv and Kidney Diseases, National
Institutes of Health, Bethesda, MD, United States; 4 Institute of Cell Engineering, Baltimore, MD, United States
To enable allogeneic mesenchymal stem cell therapy for peripheral arterial disease, we present here a novel perfluorootylbromide microcapsues that enhance
cell survival and enable cell tracking using noninvasive clinical imaging modalities.