TRADITIONAL POSTER - ismrm

Poster Sessions
1070. Influence of Drug Substances with Different Solubility on Hydration Processes of Prolonged Release
Tablets
Anna Mlynarczyk 1 , Marco Gruwel 2 , Piotr Kulinowski 1 , Krzysztof Jasinski 1 , Przemyslaw Dorozynski 3 ,
Boguslaw Tomanek, 12 , Wladyslaw P. Weglarz 1
1 Department of Magnetic Resonance Imaging, Institute of Nuclear Physics Polish Academy of Sciences, Krakow, Poland; 2 Institute
for Biodiagnostics, National Research Council of Canada, Winnipeg, Manitoba, Canada; 3 Department of Pharmaceutical Technology
and Biopharmaceutics, Jagiellonian University, Krakow, Poland
MR microscopy was applied for study of water mobility and concentration in tablets, used for drug delivery. The tablets made of
Hydroxypropylmethylcellulose-HPMC with and without addition of a drug substance of different solubility (L-dopa and ketoprofen) were tested. Twodimensional
T2 and proton density (PD) maps and their histograms were obtained. Spatial T2 and PD distributions along a tablet radius were also analyzed.
Different mechanisms of tablets hydration were observed due to composition of the formulations, eg. for formulation with ketoprofen (low solubility of 0,24
mg/mL) the hydrogel formation was negligible.
1071. Hepato and Renal Protective Effect of Bacosides Against Aluminium Insult in Rats: A Proton
Magnetic Resonance Study on Serum and Urine
Deepa Prajapati 1 , Sundeep Tripathi 2 , Sanjay Annarao 1 , Abbas Ali Mahdi 2 , Mahdi Hasan 3 , Farzana
Mahdi 4 , Raja Roy 1 , Chunni Lal Khetrapal 1
1 CBMR, Centre of Biomedical Magnetic Resonance, Lucknow, Uttar Pradesh, India; 2 CSM Medical University; 3 Anatomy, CSM
Medical University; 4 Era's Lucknow Medical College
Prolonged aluminium insults results in oxidative damage leading to hepato and nephrotoxicity in rats.1H NMR study of rat’s serum and urine have been
utilized to evaluate the comparative protective effects of Bacosides and Donepezil drugs over continuous Aluminium- induced metabonomic changes.
Bacosides was found to markedly attenuate the oxidative stress induced by Aluminium over long term (90 days) dose compared to Donepezil. This might be
interpretated in terms of strong antioxidative property of Bacosides compared to Donepezil. The study suggests that 1H NMR metabolic profiling is an
efficient method to explore the efficacy of potent molecules over metal toxicity.
1072. Effect of Varenicline on BOLD and Neural Networks in Awake Animals
Wei Chen 1 , Joseph R. DiFranza 2 , Jean King 3
1 Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, , United States; 2 Department of Family
Medicine and Community Health,, University of Massachusetts Medical School, Worcester; 3 Department of Psychiatry, University of
Massachusetts Medical School, Worcester, MA, United States
Tobacco dependence is the most preventable cause of death. Varenicline is a partial nicotinic receptor agonist/antagonist that is widely used as a smoking
cessation aid. How varenicline helps smokers is unknown. We sought to compare the brain Blood oxygenation level dependent (BOLD) activation
produced by a high dose varenicline to a lower dose varenicline in awake naïve animals, which hopes to assist in understanding the action of this partial
nicotinic receptor agonist/antagonist in patients.
Outcomes: Cost Effectiveness etc.
Hall B Thursday 13:30-15:30
1073. The EMITEL Multilingual Dictionary: A New Resource for the Global MRI Community
Stephen Frederick Keevil 1,2 , Gerard Boyle 3 , Emil Lindholm 4 , Franco Milano 5 , Freddy Stahlberg 4 , Ronnie
Wirestam 4 , Slavik Tabakov 2 , Andrew Simmons 6
1 Medical Physics, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom; 2 Imaging Sciences, King's College
London, London, United Kingdom; 3 St James's Hospital, Dublin, Ireland; 4 University of Lund, Lund, Sweden; 5 University of
Florence, Florence, Italy; 6 Centre for Neuroimaging Sciences, King's College London, London, United Kingdom
A mutilingual dictionary of terms used in MRI and other medical physics specialties has been developed by an international network of over 200 physicists
and engineers. The dictionary (available free at www.emitel2.eu) allows translation of terms between 25 languages, with extension to additional languages
planned for the future. The software platform was developed to be as simple as possible without compromising content, allowing easy update and
maximising longevity. The dictionary can be used as a free-standing resource or as a portal to an e-encyclopaedia of medical physics. Together, the
dictionary and encyclopaedia are valuable resources for the worldwide MRI community.
1074. Long Term Vascular Access Ports as a Means of Sedative Administration in a Rodent FMRI Survival
Model
Patrick C. Hettinger 1 , Rupeng Li 2 , Ji-Geng Yan 1 , Hani S. Matloub 1 , Young R. Cho 1 , Matthew L. Runquist 2 ,
Christopher P. Pawela 1,2 , James S. Hyde 2
1 Plastic Surgery, Medical College of Wisconsin, Milwaukee, WI, United States; 2 Biophysics, Medical College of Wisconsin,
Milwaukee, WI, United States
The purpose of this study is to develop a rodent survival model that enables fMRI at multiple time-points under sedation. In this study, 9 Sprague-Dawley
rats underwent surgical placement of a long-term vascular access port. The animals were then imaged using fMRI during nerve stimulation at 1 week, 3
weeks, and 5 weeks post-operatively. During imaging, all animals breathed spontaneously while intravenous sedative was administered through the port. To
date, all animals have successfully been imaged at each time-point. All vascular access ports have remained patent, making these devices a viable option for
longitudinal MRI studies requiring venous access.