TRADITIONAL POSTER - ismrm

Poster Sessions
2529. Hyperpolarized Xenon-129 Ventilation MRI: Preliminary Results in Normal Subjects and Patients
with Lung Disease
Talissa A. Altes 1 , John P. Mugler 1 , Isabel M. Dregely 2 , Stephen Ketel 3 , Iulian C. Ruset 2,3 , Eduard E. de
Lange 1 , F William Hersman 2,3 , Kai Ruppert 1
1 Radiology, University of Virginia, Charlottesville, VA, United States; 2 Physics, University of New Hampshire, Durham, NH;
3 Xemed, LCC, Durham, NH
The purpose of this study was to assess the feasibility and currently achievable quality of hyperpolarized xenon-129 ventilation (spin density) MRI in normal
subjects (n=7) and patients with asthma (n=5), chronic obstructive pulmonary disease (COPD) (n=4), cystic fibrosis (CF) (n=1), and sickle cell disease
(SCD) (n=1). As seen previously with helium, the normal subjects had homogeneous ventilation with few if any ventilation defects. Focal ventilation
defects were found in all patients with obstructive lung diseases. Qualitatively the hyperpolarized xenon-129 ventilation images are similar although not
identical to previously acquired hyperpolarized helium-3 ventilation images in different patients with similar disease states.
2530. Synchronised Acquisition of Hyperpolarised 3He and 1H MR Images of the Lungs During the Same
Breath-Hold
Jim M. Wild 1 , Salma Ajraoui 1 , Martin H. Deppe 1 , Steven R. Parnell 1 , Helen Marshall 1 , James Swinscoe 2 ,
Matthew Hatton 2 , Juan Parra-Robles 1 , Rob H. Ireland 1
1 Academic Radiology, University of Sheffield, Sheffield, Yorkshire, United Kingdom; 2 Weston Park Hopital, Sheffield, United
Kingdom
Combined 1H MRI of lung anatomy with hyperpolarised gas MRI of lung function has previously required acquisition of separate breath-hold exams, with
separate MRI pulse sequences and dedicated RF coils, resulting in images that were not spatially registered or temporally synchronised. Here 1H anatomical
and 3He ventilation MRI from human lungs were acquired in the same breath-hold using decoupled RF hardware and optimised dual acquisition MRI pulse
sequences. The resulting 3He and 1H images acquired in the same breath (from volunteers and patients with lung disease), showed superior registration to
those acquired in repeat breath-hold manoeuvres.
2531. Inter-Observer Reproducibility of Longitudinal Hyperpolarized Helium-3 Magnetic Resonance
Imaging of Chronic Obstructive Pulmonary Disease
Miranda Kirby 1,2 , Lindsay Mathew 1,2 , Andrew Wheatley 1 , David G. McCormack 3 , Grace Parraga 1,4
1 Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada; 2 Medical Biophysics, The University of
Western Ontario; 3 Division of Respirology, Department of Medicine, The University of Western Ontario; 4 Graduate Program in
Biomedical Engineering, The University of Western Ontario
Here we evaluate the associations between hyperpolarized Helium-3 Magnetic Resonance Imaging ( 3 He MRI) longitudinal changes measured in Chronic
Obstructive Pulmonary Disease (COPD) ex-smokers, with SNR and inter-observer variability. Spin density images for 15 subjects were segmented to obtain
ventilation defect volume (VDV) measurements at baseline and 26 months. Inter-observer reproducibility was determined for two observers; ICC= .93,
COV= 26% and r2= .78 (p