TRADITIONAL POSTER - ismrm

Poster Sessions
2078. A New MRI Analysis Method for Lesional Heterogeneity Characterisation in Multiple Sclerosis as
Demonstrated by Quantitative MRI.
Marios C. Yiannakas 1 , Daniel J. Tozer 1 , Declan T. Chard 1 , David H. Miller 1 , Claudia A.M Wheeler-
Kingshott 1
1 UCL - Institute of Neurology, London, United Kingdom
In this work a new MR analysis method is presented which utilises conventional FSE dual echo data sets with the use of advanced images algebra (ADIMA)
in order to enhance the dynamic range in the image with a consequent enhancement of lesional heterogeneity in MS lesions. It is found that the images show
bright and dark lesions indicating heterogeneity of pathological process. Masks of these bright and dark lesions are applied to MRI parameter maps and it is
found that the corresponding areas on MTR, T1 and T2 maps show different values, corresponding to the two lesion types.
2079. Characterization of Multiple Sclerosis Lesions Through a Quantitative Study of Perfusion Using a
Gadolinium Contrast Agent
Ryan Griffin 1 , Adam Brandenberry 1 , Jiachao Liang 1 , Christopher Murphy 1 , Trenton Rink 1 , Joe Konrad 1 ,
Xiangyu Yang 1 , Michael Knopp 1 , Steffen Sammet 1
1 Radiology, The Ohio State University, Columbus, OH, United States
The purpose of this study was to use Dynamic Contrast Enhanced MRI at 3T to quantitatively study the perfusion of MS lesions. Using Brix’s two
compartment model, we found statistically significant differences in the mean extracted values of the pharmacokinetic values Amp and k el of enhancing
lesions with respect to those from normal appearing brain tissue, as well as a statistically significant difference in the mean extracted value of Amp from
hypointense lesions with respect to normal appearing brain tissue. Rising enhancement after the initial uptake of gadolinium (indicated by a negative k el
value) was observed for every enhancing lesion.
2080. Altered Brain Perfusion and Tissue Injury in Early Multiple Sclerosis Assessed by ASL and MTR
Statistical Mapping Analyses
Wafaa Zaaraoui 1 , Françoise Reuter 1 , Mathias Lemaire 1 , Audrey Rico 1 , Anthony Faivre 1 , Virginie Callot 1 ,
Irina Malikova 1 , Elisabeth Soulier 1 , Sylviane Confort-Gouny 1 , Patrick J. Cozzone 1 , Jean Pelletier 1 ,
Bertrand Audoin 1 , Jean-Philippe Ranjeva 1
1 Faculté de Médecine, CRMBM UMR CNRS 6612, Marseille, France
Recent studies have evidenced the crucial role of perfusion alteration in multiple sclerosis (MS). However, little is known about the relationships between
hemodynamical parameters and local tissue damage encountered at all stages of the disease, and especially at the early phase. To investigate the putative
relationships between perfusion alterations and structural local white matter and grey matter impairments in early MS, we designed a MR protocol
combining statistical mapping analyses of arterial spin labeling (ASL) data and magnetization transfer ratio (MTR) data obtained in 12 patients with
clinically isolated syndromes (CIS) and 12 matched controls.
2081. Identifying the Start of Multiple Sclerosis Tissue Injury: A Longitudinal DTI Study
Robert J. Fox 1 , Daniel Ontaneda 1 , Xiofeng Wang 2 , Ken Sakaie 3 , Jian Lin 3 , Mark J. Lowe 3 , Michael D.
Phillips 3
1 Mellen Center for MS, Cleveland Clinic, Cleveland, OH, United States; 2 Quantitative Health Sciences, Cleveland Clinic, Cleveland,
OH, United States; 3 Radiology, Cleveland Clinic, Cleveland, OH, United States
We used HARDI DTI in a longitudinal study of multiple sclerosis patients to identify changes in brain tissue prior to the development of acute inflammation
(gadolinium enhancement). We found significantly decreased fractional anisotropy (FA) up to 10 months prior to the development of gadolinium-enhancing
lesions. Changes in FA were driven an increase in transverse diffusivity, while longitudinal diffusivity remained unchanged. This study provides evidence
for impaired myelin integrity up to 10 months prior to development of gadolinium enhancement.
2082. Corpus Callosum Atrophy and Diffusion Abnormalities in Clinically Isolated Syndrome Revealed by
Diffusion Tensor Tractography
Fuchun Lin 1 , Chunshui Yu 2 , Yaou Liu 2 , Hao Lei 1
1 Wuhan Institute of Physics & Mathematics, The Chinese Academy of Sciences, Wuhan, Hubei, China; 2 Department of Radiology,
Xuanwu Hospital of Capital Medical University, Beijing, China
Diffusion tensor based group tractography was used to determine the corpus callosum (CC) integrity in clinically isolated syndrome (CIS). Compared to the
healthy subjects, the CIS patients had significantly reduced midsagittal CC area, and significantly higher MD, λ 1, λ 23 and significantly lower FA in the entire
CC. Moreover, the average FA of the normal-appearing CC of the CIS patients correlated negatively with the whole-brain lesion load while the other three
diffusion indices correlated with the lesion load positively. These results suggested that both the morphology and the microstructure of the CC appear to be
damaged at the stage of CIS.
2083. Characterization of Early White Matter Damages in Multiple Sclerosis Patients with a Clinically
Isolated Syndrome: A Tract Based Spatial Statistics Study
Salem Hannoun 1,2 , Françoise Durand-Dubief, 1,3 , Christian Confavreux 3 , Dominique Sappey-Marinier 1,2
1 CREATIS-LRMN, University of Lyon 1, Lyon, Rhone-Alpes, France; 2 CERMEP-Imagerie du Vivant, Bron, Rhone-Alpes, France;
3 Neurological Hospital, Lyon, Rhone-Alpes, France
This study aims to characterize early pathological processes occurring in twelve multiple sclerosis (MS) patients with a clinically isolated syndrome (CIS)
compared to relapsing remitting (RR) patients and control subjects using tract-based spatial statistics (TBSS). Significant alterations of diffusivity including
FA decrease, and axial (ëa) and radial (ër) diffusivities increases, were found in extensive white matter regions of CIS patients, with ër being the most
affected. If ër alterations may reflect the demyelinating processes occurring in MS, ëa can be more evocative of late appearing axonal damage as confirmed
by the increase of ëa in RR compared to CIS patients.