TRADITIONAL POSTER - ismrm

Poster Sessions
coefficient (ADC) and imaging/histopathological features of vulnerability (thin cap, lipid core, haemorrhage, angiogenesis (CD105 or VEGF) &
inflammation (CD68). Mean (SD) plaque ADC was 1.30 X10-3(0.29) mm2/s. There was no difference in ADC between patients with and without MRI
features of plaque vulnerability. There was a positive trend between ADC & CD105/VEGF, markers of angiogenesis meriting further investigation.
2221. Differing Fractional Anisotropy Changes in Grey Matter and White Matter in Early Ischemic Stroke
Mohamed Mustafa Hirji 1,2 , Ashley D. Harris, 2,3 , Robert K. Kosior, 2,4 , Cheryl R. McCreary, 2,5 , Richard
Frayne 2,5
1 University of Calgary, Calgary, Alberta, Canada; 2 Seaman Family MR Research Centre, Alberta Health Services, Calgary, Alberta,
Canada; 3 School of Psychology & Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, Wales, United
Kingdom; 4 Biomedical Engineering, University of Calgary, Calgary, Alberta, Canada; 5 Radiology & Clinical Neurosciences,
University of Calgary, Calgary, Alberta, Canada
We characterise the fractional anisotropy (FA) changes in ischemic stroke. Diffusion tensor images of 13 patients were obtained within 26 hours of stroke
(acutely) and >21 days later (follow-up). FA and eigenvalues were measured in freehand regions of interest (ROIs); anatomically-matched contralateral
ROIs were used for control. Acutely, FA increased in gray matter (GM) but not in white matter (WM); the eigenvalue reductions were unbalanced in GM,
but balanced in WM. At follow-up, FA decreased in both GM and WM with the eigenvalue changes similar in both GM and WM. Our results give insight
into microstructural changes in stroke.
2222. Intensive Blood Pressure Lowering Increases Cerebral Blood Flow in Older Subjects with
Hypertension
Jiabao He 1 , Dinesh Tryambake 1 , Michael J. Firbank 2 , John T. O’Brien 2 , Gary A. Ford 1 , Andrew M.
Blamire 1
1 Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom; 2 Institute for Ageing
and Health, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
CBF determines brain tissue metabolic supply and is compromised in chronic hypertension which alters autoregulatory function. Blood pressure (BP)
lowering therapy has clear clinical benefit but may risk inducing hypoperfusion. Optimal target BP in older subjects with hypertension is unclear, although
guidelines recommend target BP of