TRADITIONAL POSTER - ismrm

Poster Sessions
2211. Brain MR Imaging and 1H-MR Spectroscopy Changes in Patients with Extra-Hepatic Portal Vein
Obstruction from Early Childhood to Adulthood
Santosh Kumar Yadav 1 , Sona Saksena 1 , Anshu Srivastava 2 , Arti Srivastava 1 , Vivek A. Saraswat 3 , Michael
A. Thomas 4 , Ram Kishore S. Rathore 5 , Rakesh K. Gupta 1
1 Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 2 Pediatric
gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 3 Gastroenterology,
Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 4 Radiological Sciences, UCLA School of
Medicine, Los Angeles, CA, Los Angeles, CA, United States; 5 Mathematics and Statistics, Indian Institute of technology Kanpur,
Kanpur, Uttar Pradesh, India
Sixty-three patients with EHPVO having different age groups with 47 age/sex matched controls were studied. Neuropsychological tests, MR imaging, 1H-
MR Spectroscopy and blood-ammonia estimation were performed in all subjects. 40% EHPVO patients had MHE who showed significantly increased Mean
diffusivity, Glx/Cr, blood-ammonia and GP T1 H in all age groups; however, mIns/Cr was significantly lower only in adults when compared to controls.
Mean diffusivity positively correlated with blood-ammonia and Glx/Cr in all age groups. A significant positive correlation was observed between Glx/Cr
and blood-ammonia. Increases in Mean diffusivity, Glx/Cr, blood-ammonia and GP T1 H and decrease in mIns/Cr are associated with pathogenesis of MHE
in adults with EHPVO. No change of cho/Cr in EHPVO may serve as a diagnostic marker for its differentiation from cirrhosis induced MHE. A significant
positive correlation among blood ammonia, Glx/Cr and mean diffusivity indicates that hyperammonia contributes to the generalized low grade cerebral
edema.
2212. Repeatability of Measured Lactate and Other Metabolites in Patients with Astrocytoma
Mary McLean 1 , Amy Sun 2 , Radha Railkar 2 , Andrea Schaeffer 2 , Thomas Bradstreet 2 , Haiying Liu 2 , Roseann
Blenman-Abange 2 , Ilse Joubert 3 , Stephen Price 3 , Charlotte Hodgkin 3 , John Griffiths 1
1 Cambridge Research Institute, Cancer Research UK, Cambridge, England, United Kingdom; 2 Merck & Co Inc, West Point, PA,
United States; 3 Addenbrooke's Hospital, Cambridge, United Kingdom
We implemented lactate editing at 3T using BASING pulses and assessed its repeatability in phantoms and in human brain tumours in vivo to estimate the
level of lactate and other metabolites . In phantoms, a coefficient of variation of 11% was achieved for lactate with SNR similar to in vivo. In tumours,
lactate was detected, and there was a non-significant trend of lower metabolite concentrations in scan 2 than scan 1. Lactate editing may provide a useful
means of simultaneously monitoring lactate, choline and lipids in vivo, all of which are of interest in tumour progression and response to treatment.
2213. Differentiation Between Low and High Grade in Non-Enhancing Cerebral Gliomas and Neuronal-
Glial Tumors
Xiang Liu 1 , Wei Tian 1 , Sven Ekholm 1
1 Department of Imaging Science, University of Rochester Medical Center, Rochester, NY, United States
Grading of non-enhancing supratentorial gliomas and neuronal-glial tumors (NEGNGT) is a diagnostic dilemma on conventional MR imaging as 45% of
these tumors could be malignant. We retrospectively compared diffusion tensor imaging (DTI), MR perfusion weighted imaging (PWI) and MR
spectroscopic imaging in preoperative grading of 50 patients with histology confirmed non-enhancing supratentorial gliomas and neuronal-glial tumors. The
imaging parameters, included mean FA, mean FA ratio, maximal FA, minimal ADC, maximal rCBV, Cho/Cr and Cho/NAA which all were evaluated for
both tumor groups. There were significant differences of mean FA, mean FA ratio and maximal FA between low and high grade NEGNGT(p