TRADITIONAL POSTER - ismrm

Poster Sessions
1201. Investigating the Role of Transcallosal Projections in Mediating Neuroplasticity Following Injury in a
Rat Using FMRI
Jennifer I. Wood 1,2 , Suresh E. Joel 1,3 , Michael T. McMahon 1,2 , James J. Pekar 1,2 , Galit Pelled, 2,4
1 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; 2 The Russell H.
Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United
States; 3 The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine,
Baltimore, MD, United States; 4 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute , Baltimore,
MD, United States
Human and animal studies suggest the involvement of the transcallosal projection in shaping neuroplasticity following injury may be crucial in dictating the
rehabilitation probability. This study was designed to investigate the role of the transcallosal pathways in mediating neuroplasticity following injury in a rat
model of sensory deprivation. Using fMRI, we have studied the time course and the age-dependency of which the transcallosal projections effect cortical
reorganization. The results demonstrate that the transcallosal projections involvement in neuroplasticity varies dependent on the age and the time following
the injury and may introduce a critical consideration when choosing the right rehabilitation strategy.
1202. BOLD FMRI Assessment of the Functional Response to Taste Stimulation in Rat Brain
Ikuhiro Kida 1 , Yoko Hoshi 1 , Yoshinobu Iguchi 1
1 Integrated Neuroscience Research Team, Tokyo Institute of Pschiatry, Setagaya-ku, Tokyo, Japan
Some aspects of taste information processing have not been conclusively clarified, such as the process by which the gustatory cortex uses spatial codes to
characterize taste information.We used BOLD fMRI measurements obtained at 7 T in an animal system to investigate the process by which taste information
is encoded. Sucrose yielded a reproducible BOLD signal increase in the gustatory cortex. During taste stimulation, BOLD signals were also detected in the
lip region of the primary somatosensory cortex, secondary somatosensory cortex, and amygdalae. This is the first study that used BOLD fMRI to observe
gustatory activation in the rat brain.
1203. Functional MRI of Cortico-Striato-Thalamal Circuit Using a Novel Flexible Polyimide-Based
Microelectrode Array Implanted in Rodent Deep Brain
Pai-Feng Yang 1 , You-Yin Chen 2 , Jyh-Horng Chen 1 , Chen-Tung Yen 3
1 Electrical Engineering, National Taiwan University, Taipei, Taiwan; 2 Electrical Engineering, National Chiao-Tung University,
Hsinchu, Taiwan; 3 Zoology, National Taiwan University, Taipei, Taiwan
This paper proposes a novel flexible MRI-compatible microelectrode array that leverages the stimulation and recording properties for neuroscience
application. We perform functional MRI to investigate the cortico-striato-thalamal circuit with thalamic stimulation. Significant positive BOLD responses
were observed in receptive field in upper lip region (S1ULp), barrel field (S1BF) and secondary somatosensory cortex (S2). Negative BOLD responses were
revealed in caudate putamen (CPu). We inferred a limbic cortico-striatal loop might exist.
1204. A Non Invasive Experimental Protocol for FMRI Studies: Investigation of the Basal Ganglia-Cortex
Circuit in a Rat Model
Salem Boussida 1 , Amidou Traore 2 , Jean-Pierre Renou 2 , Franck Durif 3
1 INRA, UR370 QuaPA/NMR plateforme, Centre Clermont-Ferrand/Theix, F-63122 Saint Genès Champanelle, France; 2 INRA,
UR370 QuaPA/NMR plateforme, Centre Clermont-Ferrand/Theix, F-63122 Saint Genès Champanelle, France; 3 CHU Clermont-
Ferrand, Service de Neurologie, Clermont-Ferrand, F-63001, France.
Combination of blood– oxygen level-dependent functional magnetic resonance imaging (BOLD fMRI) and electrical hindpaw stimulation has been used as a
standard model to study the somatosensory pathway and brain rehabilitation in rats. In the present study, we examined the feasibility of performing BOLD
fMRI experiments on rat to investigate the activity of the basal ganglia (BG)-cortex circuit associated to hindpaw sensitive stimulation. These findings will
have relevance in the fMRI studies dealing with physiopathology of neurodegenerative diseases such as Parkinson
1205. Refining the Sensory and Motor Ratunculus of the Rodent Upper Extremity: Evaluation of the C7
Nerve Root Using FMRI and Direct Nerve Stimulation
Patrick C. Hettinger 1 , Rupeng Li 2 , Ji-Geng Yan 1 , Hani S. Matloub 1 , Young R. Cho 1 , Matthew L. Runquist 2 ,
Christopher P. Pawela 1 , James S. Hyde 2
1 Plastic Surgery, Medical College of Wisconsin, Milwaukee, WI, United States; 2 Biophysics, Medical College of Wisconsin,
Milwaukee, WI, United States
The purpose of this study is to further define the ratunculus by observing cortical activity using BOLD fMRI during direct stimulation of the C7 nerve root.
In this study, 7 Sprague-Dawley rats underwent implantable electrode placement on the C7 nerve root. BOLD response to nerve stimulation was then
studied using a Bruker 9.4T MRI scanner. C7 nerve stimulation resulted in a small amount of activation in the S1FL region along with a large amount of
activation within the M1/M2 regions. These findings are similar to the sensory and motor distributions described in human C7 nerve root literature.
1206. Functional MRI Detects Chronically Enhanced Somatosensory Activation Maps Following Multiple
Seizures in Rats.
Ursula I. Tuor 1 , Jennifer Vuong 2 , Jeffrey F. Dunn 3 , Tadeusz Foniok 1 , Dave Kirk 4 , Amy H. Henderson 2 , G
Campbell Teskey 2,5
1 Institute for Biodiagnostics (West), National Research Council of Canada , Calgary, Alberta, Canada; 2 Psychology, University of
Calgary; 3 Radiology, University of Calgary; 4 Experimental Imaging Centre, University of Calgary; 5 Anatomy and Cell Biology,
University of Calgary, Calgary, Alberta, Canada
We used functional magnetic resonance imaging (fMRI) in rats to investigate whether following 20 repeatedly elicited seizures there are seizure-induced
alterations in the somatosensory maps to forepaw stimulation. We observed increased areas of activation both acutely (1-3 days) and chronically (3-5