Poster Sessions to monitor both the progress of the insertion and the procedure itself, such as core needle biopsy or tumor ablation. Flexibility was added to adjust the scan plane in real-time and make tradeoffs between update display rate and image quality. 1840. A Passive, Image-Based Navigation Tool for Real-Time MR-Guided Percutaneous Interventional Procedures Wilhelm Strehl 1 , Eva Rothgang 1,2 , Wesley Gilson 2 , Klaus J. Kirchberg 3 , Joachim Hornegger 1 , Christine Lorenz 2 1 Pattern Recognition Lab, Department of Computer Science, University of Erlangen-Nuremberg, Erlangen, Bavaria, Germany; 2 Center for Applied Medical Imaging, Siemens Corporation, Corporate Research, Baltimore, MD, United States; 3 Center for Applied Medical Imaging, Siemens Corporation, Princeton, NJ, United States Percutaneous interventions involve the navigation of a needle or probe to a target location. MRI is well-suited to guide these procedures as it offers good soft tissue target visualization and no ionizing radiation. High field wide bore MRI has stimulated interest in performing more of these procedures, but workflow and procedure speed are significant hurdles for full adoption. Here, a navigation tool for guiding and tracking the needle in real-time under MRI is presented. 1841. Navigated Liver Biopsies in a Closed-Bore MR Scanner: First Clinical Experience Michael Moche 1 , Gregor Thörmer 1 , Nikita Garnov 1 , Jochen Fuchs 1 , Susann Heinig 1 , Tim Riedel 1 , Thomas Kahn 1 , Harald Busse 1 1 Leipzig University Hospital, Leipzig, Germany MRI has been shown to be of great clinical utility for the guidance of various procedures. In a closed-bore scanner, the simplest approach is to manipulate the instrument outside the bore and move the patient inside for control imaging only. Potential benefits for percutaneous biopsies in the liver have been investigated in 15 patients by using a flexible add-on navigation solution which even allowed interventions in obese patients. Real time navigation was provided by following the virtual instrument on properly reformatted images of a 3D roadmap. In combination with a specific breathhold protocol, punctures could be reliably performed in reasonable times. 1842. Evaluation of a Real Time MR-Guided Interactive Navigation Device: Phantom and Animal Experiments Steffi Valdeig 1 , Barry Fetics 2 , Li Pan, 1,3 , Clifford R. Weiss 1 , Erez Nevo 2 , Dara L. Kraitchman 1 , Frank K. Wacker 1 1 Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States; 2 Robin Medical Inc., Baltimore, MD, United States; 3 Center for Applied Medical Imaging, Siemens Corporation, Corporate Research, Baltimore, MD, United States Purpose: To test the feasibility and accuracy of a tool that allows for interactive adjustments of the needle plane during a MR guided puncture Method: Experiments were performed in vivo and in phantoms using a gradient based navigation system for real time MR guided punctures in a wide bore MR imager. To assess for accuracy of the system the distance of the needle tip (virtual and real) to the target was determined on MR control scans. Result: The mean 3D total error was 4.9 ±2.8mm in the phantom. The system error was less than 2 mm. In the animal, successful punctures of the target structures could be confirmed in all punctures. Conclusion: The combination of image overlay with real time adjustment of the virtual needle and real-time imaging feedback provides an accurate and intuitive means to perform percutaneous interventions in a wide bore MR imager. 1843. Fast and Precise: Real Time MR-Guided Prostate Biopsy at 3 Tesla in Animal Experiment. Patrik Zamecnik 1 , Axel j. Krafft 2 , Florian Maier 3 , Jaane Rauschenberg 2 , Michael Bock 2 1 DKFZ German Cancer Research Center), Heidelberg, Baden-Württemberg, Germany; 2 DKFZ (German Cancer Research Center); 3 DKFZ (German Cancer Resaerch Center) Real time MR-guided prostate biopsy at 3 Tesla in animal experiment proved to be a fast an precise method to perform prostate biopsies. 1844. Development of a Pneumatic Robot for MRI-Guided Transperineal Prostate Intervention Sang Eun Song 1 , Nathan Bongjoon Cho 1 , Iulian Iordachita 2 , Gregory Scott Fischer 3 , Junichi Tokuda 4 , Nobuhito Hata 4 , Gabor Fichtinger 5 , Clare Tempany 4 1 Engineering Research Center, The Johns Hopkins University, Baltimore, MD, United States; 2 Department of Mechanical Engineering, The Johns Hopkins University, Baltimore, MD, United States; 3 Mechanical Engineering Department, Worcester Polytechnic Institute, Worchester, MA, United States; 4 Brigham and Women’s Hospital, Boston, MA, United States; 5 School of Computing,, Queen’s University, Kingston, Ontario, Canada As accurate needle positioning helps the prostate cancer detection and treatment, a number of MRI-compatible robots have been introduced. However, problems exist due to the strong magnetic field and limited workspace. Pneumatic actuator has the minimum distraction in the environment. However, it has poor controllability. To overcome the controllability problem, a simple external damping mechanism that can enhance accuracy was developed. Based on the actuator mechanism and workflow optimized modular design approaches, a new pneumatically actuated 4-DOF parallel robot for MRI-guided prostate intervention was developed. A preliminary evaluation was conducted with satisfying actuator average position error of 0.2mm.
Poster Sessions 1845. Development and Preliminary Evaluation of a MRI-Guided Transrectal Prostate Intervention Axel Krieger 1,2 , Sang Eun Song 3 , Nathan Bongjoon Cho 3 , Peter Guion 4 , Iulian Iordachita 1 , Gabor Fichtinger 5 , Louis L. Whitcomb 1 1 Department of Mechanical Engineering, The Johns Hopkins University, Baltimore, MD, United States; 2 Sentinelle Medical Inc., Toronto, Canada; 3 Engineering Research Center, The Johns Hopkins University, Baltimore, MD, United States; 4 National Institute of Health, Bethesda, MD, United States; 5 School of Computing,, Queen’s University, Kingston, Ontario, Canada This paper reports the design, development and MRI compatibility evaluation of a transrectal prostate robot for MRI-guided intervention. The robot employs an automated needle guide with the goal of increasing needle placement accuracy and reducing interventional procedure times. The design of the robot, employing piezo-ceramic-motor actuated needle guide and manual needle insertion, is reported. Results of a MRI compatibility study show no reduction of MRI image SNR with the motors disabled and a 40% to 60% reduction with the motors enabled. The addition of RF shielding is shown to significantly reduce SNR degradation to the presence of the robotic device. 1846. A Device to Facilitate the Performance of Magic Angle Studies on the Wrist and Elbow Marc Rea 1,2 , Zion Tsz Ho Tse 3 , Haytham Elhawary 3 , Michael Lampérth 2 , Graeme Bydder 4 , Ian Young 5 1 Radiological Sciences Unit, Imperial College London, London, UK, United Kingdom; 2 Mechanical Engineering, Imperial College London, London, England, United Kingdom; 3 Brigham Womens Hospital, Boston, United States; 4 Radiology, University of California San Diego, San Diego, CA, United States; 5 Electrical Engineering, Imperial College London, London, United Kingdom A limb-positioning mechanical platform device was developed for remote orientation of the arm to make use of the magic angle effect for imaging tendons. The platform is MR-compatible and actuated by rotary air-driven motors. Clinical trials are imminent. 1847. Intra-Procedural MRI-Monitoring of Irreversible Electroporation of Liver Tissues in Rodent Model Yue Zhang 1,2 , Yang Guo 2 , Ann B. Ragin 2 , Robert J. Lewandowski 2,3 , Guang-yu Yang, 3,4 , Grace M. Nijm 5 , Alan V. Sahakian 5 , Reed A. Omary 2,3 , Andrew C. Larson 2,3 1 Bioengineering, University of Illinois at Chicago, Chicago, IL, United States; 2 Radiology, Northwestern University, Chicago, IL, United States; 3 Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, United States; 4 Pathology, Northwestern University, Chicago, IL, United States; 5 Electrical Engineering and Computer Science, Northwestern University, Evanston, IL, United States MRI permits immediate depiction of ablated tissue zones for intra-procedural monitoring during irriversible electroporation (IRE) ablation procedures. MRI monitoring offers the potential to permit intra-procedural optimization of IRE procedures to ensure complete ablation of targeted tissue volumes. 1848. Early Visualization of the Irreversible Electroporation Ablated Tissue Margin by Contrast Enhanced Imaging in Rodent Model Yang Guo 1 , Yue Zhang 1,2 , Grace Nijm 3 , Alan Sahakian 3 , Guang-Yu Yang 4 , Reed Omary 1,5 , Andrew Larson 1,5 1 Department of Radiology, Northwestern University, Chicago, IL, United States; 2 Department of Bioengineering , University of Illinois at Chicago, Chicago, IL, United States; 3 Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, IL, United States; 4 Department of Pathology, Northwestern University, Chicago, IL, United States; 5 Department of Biomedical Engineering , Northwestern University, Chicago, IL, United States Electroporation involves targeted delivery of electrical pulses to permeabilize cell membranes, either reversible or irreversible. Irreversible electroporation (IRE), as a new tissue ablation technique, induces tissue necrosis due to permanent cell membrane defects. Assessment of tissue response to IRE may be critical. For our study, we demonstrate that inversion recovery prepared contrast enhancement imaging, with TI adjusted to null the signal intensity from the reversible zone, can visualize the IRE ablated tissue margin (differentiating reversible/irreversible zones) to provide an accurate prediction of ablation. This technique can early detect tissue response to IRE and might be helpful to guide further treatments. 1849. MRI-Guided Focused Ultrasound for Local Delivery of Anti-Aβ Antibodies in a Mouse Model of Alzheimer’s Disease Jessica F. Jordao 1,2 , Carlos A. Ayala-Grosso 3,4 , Yuexi Huang 1 , JoAnne McLaurin 2 , Isabelle Aubert, 2,4 , Kullervo Hynynen 1,5 1 Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 2 Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada; 3 Unidad de Biología Molecular, Universidad Central de Venezuela, Los Chaguaramos, Venezuela; 4 Brain Sciences Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 5 Medical Biophysics, University of Toronto, Toronto, ON, Canada The use of antibodies to target toxic amyloid-beta peptides (Aβ) in the brain of Alzheimer’s patients has shown promise in clinical trials but still faces some difficulties. The blood-brain barrier remains a major obstacle; preventing intravenously delivered antibodies from reaching the brain. In this study, we use transcranial MRI-guided focused ultrasound to efficiently deliver antibodies to the brain of a mouse model of Alzheimer’s disease and evaluate the efficacy of this treatment. We found that delivery of the antibody is localized to targeted regions and yields a rapid and significant reduction of Aβ plaque load from a single treatment.
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