TRADITIONAL POSTER - ismrm

Poster Sessions
With the control system, it was clearly demonstrated that the stress level is far more stable during the entire session and inter-subject variation in the
metabolic alterations is significantly reduced. It is expected to assess cardiac function and metabolite alteration during moderate stress with higher precision
by using automatic stress control system.
1320. The Effects of Fasting on Myocardial Lipid Content in Fatty Acid β-Oxidation Deficient Mice Studied
with in Vivo 1 H-MRS
Adrianus Johannes Bakermans 1 , Sander M. Houten 2 , Tom R. Geraedts 1 , Michel van Weeghel 2 , Klaas
Nicolay 1 , Jeanine J. Prompers 1
1 Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 2 Laboratory Genetic Metabolic Diseases,
Academic Medical Centre, Amsterdam, Netherlands
A respiratory gated, cardiac triggered PRESS 1 H-MRS sequence was used to investigate effects of fasting on lipid content in the long chain acyl-coenzyme
A dehydrogenase knockout (LCAD -/- ) mouse heart. Left ventricular (LV) function and morphology were assessed using cine MRI. LV mass normalized to
body weight was larger in LCAD -/- mice than in controls, indicating LV hypertrophy. There was a trend for a decrease in ejection fraction after fasting,
accompanied by increased lipid content in LCAD -/- mice compared to controls. It remains to be established whether there is a causal relationship between
increased myocardial lipid content and decreased cardiac function.
1321. Navigator Gated and Cardiac Triggered Echo-Planar Spectroscopic Imaging of the Heart
Kilian Weiss 1 , Nicola Martini 2 , Peter Boesiger 1 , Sebastian Kozerke 1
1 Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; 2 Interdepartmental Research Center "E.
Piaggio", University of Pisa, Pisa, Italy
Single-voxel proton magnetic resonance spectroscopy has been shown to be a promising tool for assessing creatine and myocardial triglycerides in humans.
While spectral information from a single volume is sufficient when alterations with global effects on the heart are studied, a demand for higher and flexible
spatial resolution exists when probing local changes. To this end, implementation of fast spectroscopic imaging of the heart is desired. The objective of the
current work was to implement and optimize navigator gated and cardiac triggered Echo-Planar Spectroscopic Imaging (EPSI) for assessment of triglyceride
and creatine content in the myocardium in vivo.
1322. Cardiac Lipid Content and Systolic Function in Overweight Type 2 Diabetic Subjects After Exercise
Training
Vera Schrauwen-Hinderling 1 , Ruth Meex 1 , Jan Glatz 1 , Joachim Wildberger 1 , Hildo Lamb 2 , Michael
Schär 3,4 , Matthijs Hesselink 1 , Patrick Schrauwen 1 , Marianne Eline Kooi 1
1 Maastricht University Medical Center, Maastricht, Netherlands; 2 Leiden University Medical Center, Leiden, Netherlands; 3 Johns
Hopkins University, Baltimore, United States; 4 Philips Health Care, Cleveland, United States
Excessive cardiac lipid storage might hamper cardiac function via ‘lipotoxic’ pathways. We investigated the response of cardiac lipids to exercise training in
patients with type 2 diabetes mellitus. Maximal whole body oxygen uptake and LV-ejection fraction (by CINE-MRI) were improved while cardiac lipid
content (by 1H-MRS) was unchanged after training. This is in contrast to our earlier findings in healthy overweight subjects, where such a training
intervention diminished cardiac lipid content. This may indicate hampered exercise-induced lipid mobilization in the diabetic heart and reveals that reduction
of cardiac lipids is not a prerequisite for the training-induced improvement in cardiac function.
1323. Myocardial Steatosis Is Associated with Regional Ventricular Dysfunction
Chia-Ying Liu 1 , Alban Redheuil 1 , Elzbieta Chamera 1 , Joao Lima 1 , David Bluemke 2 , Shenghan Lai 3
1 Department of Radiology, Johns Hopkins Hospital, Baltimore, MD, United States; 2 Radiology and Imaging Sciences, National
Institutes of Health, Bethesda, MD, United States; 3 Department of Epidemiology, Johns Hopkins School of Hygiene and Public health,
Baltimore, MD, United States
The increased myocardial triglyceride pool is associated with impaired myocardial function in animal experiments. Human studies also indicate that
myocardial steatosis is associated with impaired left ventricular filling dynamics and diastolic dysfunction. Proton Magnetic Resonance Spectroscopy (1H-
MRS) has proven to be reliable and reproducible in measuring myocardial triglyceride content in humans. The primary goal of the present study was to
evaluate the myocardial fat content in cardiovascularly asymptomatic HIV infected and non-infected individuals using 1H-MRS, and to correlate the septal
triglyceride content to the regional ventricular function measured by tagged MRI.
1324. Intramyocardial Lipid Quantification by MRS: in Vivo Validation in Human Subjects
Robert D. O'Connor 1 , Jian Xu 2 , Linda R. Peterson 3 , Gropler J. Robert 1 , Adil Bashir 1
1 Radiology, Washington University, St. Louis, MO, United States; 2 Siemens, NY, United States; 3 Internal Medicine, Washington
University, St. Louis, MO, United States
An MRS assay of myocardial lipid is characterized and its accuracy and specificity cross-validated with ex vivo high resolution NMR measurements via
endomyocardial biopsies from heart transplant patients.