TRADITIONAL POSTER - ismrm

Poster Sessions
superparamagnetic iron oxide (SPIO) can non-invasively image HER-2 expressing cells or tissues both in vitro and in vivo by MRI. This preliminary study
demonstrates that Affibody-SPIO is a feasible target specific contrast agent for in vivo MR-molecular imaging.
1937. Creation of an Multimeric Anti-P53 ScTCR-SPIO Conjugate for the Detection of Cancer in MR
Richard Wong 1,2 , Tian Liu 1,2 , Xiao-Yun Zhu 3 , Hing C. Wong 3 , Yi Wang 1,4
1 Cornell University, Ithaca, NY, United States; 2 Department of Radiology, Cornell University - Weill Medical College, New York,
NY, United States; 3 Altor Bioscience Corp, Miramar, FL, United States; 4 Department of Radiology, Weill Medical College, New
York, NY, United States
We have created an anti-p53 scTCR-SPIO for use as a generalized cancer detection contrast agent for use in MR. In vitro models demonstrate the
effectiveness of this molecule in labeling p53-expressing cells and suggests future application in in vivo cancer models.
Imaging of Dementia & Neurodegeneration
Hall B Tuesday 13:30-15:30
1938. Degeneration of Subcortical White Matter in Alzheimer's Disease: Atlas-Based Automated Mapping
and Its Diagnostic Utility Based on Multi-Variate Model
Takashi Yoshiura 1 , Akio Hiwatashi 1 , Koji Yamashita 1 , Hironori Kamano 1 , Yukihisa Takayama 1 , Eiki
Nagao 1 , Tuvshinjargal Dashjamts 1 , Hiroshi Honda 1
1 Department of Clinical Radiology, Kyushu University, Fukuoka, Japan
We measured mean diffusivities (MD) in subcortical white matter (WM) in 78 different cortical regions using an atlas-based mapping method in 33 patients
with Alzheimerfs disease (AD) and 28 healthy control subjects to determine whether the topographical pattern of the diffusion abnormalities can be used to
diagnose AD. Uni-variate analysis in which discrimination was attempted based on MD in the single region resulted in the accuracy of 88.5 %. Multi-variate
analysis in which a linear discriminant function based on MDs from multiple cortical regions increased the accuracy up to 96.7 %.
1939. Deterioration of Abstract Reasoning Ability in MCI and Alzheimer's Disease: Correlation with Local
Gray Matter Volume Loss Using DARTEL VBM Analysis
Takashi Yoshiura 1 , Akio Hiwatashi 1 , Koji Yamashita 1 , Hironori Kamano 1 , Yukihisa Takayama 1 , Eiki
Nagao 1 , Tuvshinjargal Dashjamts 1 , Hiroshi Honda 1
1 Department of Clinical Radiology, Kyushu University, Fukuoka, Japan
We estimated brain regions whose damages are responsible for the deterioration in abstract reasoning ability measured by Ravenfs colored progressive
matrices (CPM) in 37 patients with Alzheimerfs disease (AD) (n=19) and mild cognitive impairment (MCI) (n=18) using VBM with non-linear
registration based on DARTEL algorithm. A multiple regression analysis was used to map the regions where gray matter volumes were correlated with CPM
scores. Significant correlations were seen in 14 regions with the strongest correlation in the left middle frontal gyrus. Results suggested that damages of
multiple regions are responsible for deterioration of abstract reasoning ability in AD and MCI.
1940. MRI Shape Analysis Predicts Progression from Mild Cognitive Impairment to Alzheimer's Disease
Donald Louis Collins 1 , Vladimir Fonov 1 , Simon Duchesne 2,3
1 McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, QC, Canada; 2 Centre de Recherche Université Laval -
Robert Giffard, Quebec, Canada; 3 Dépt. de Radiologie, Faculté de Médecine, Université Laval, Quebec, Canada
A method is presented to predict conversion from mild cognitive impairment to Alzheimer’s disease using shape analysis of baseline T1w MRI data. Using
100 MCI subjects from the ADNI database, PCA analysis of deformation fields required to register to a minimum deformation template is used to build a
shape model of the aging brain. LDA of the eigenvalues is used to build a classifier to identify converters and non-converters. Testing with 100 additional
MCI subjects demonstrates accuracies of 65% at 12 months and 64% at 24 months. Adding baseline HC volume increases accuracy to 73% and 69%,
respectively.
1941. Ultra-High Field MRS in Healthy Aging and Early Cognitive Impairment
Mary Charlotte Stephenson 1 , Mirjam I. Schubert 2 , Maryam Abaei 2 , Antonio Napolitano 2 , Rob G. Jones 3 ,
Peter G. Morris 1 , Dorothee P. Auer 2
1 SPMMRC, School of Physics and Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom;
2 Academic Radiology, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 3 School of Community Healthy
Sciences, University of Nottingham, Nottingham, Nottinghamshire
Metabolic profiles in the posterior cingulate cortex (PCC) have been found to be altered due to healthy aging and in many neurodegenerative diseases. The
purpose of this study was to use increased spectral resolution and signal, available at higher field, to measure changes in the PCC metabolic profile due to
healthy aging and cognitive impairment. Atrophy corrected levels of N-acetyl aspartate, glutamate and aspartate were found to significantly decrease with
healthy aging. Levels of phosphocreatine were greatly reduced in patients with cognitive impairment, supporting a crucial role for Creatine Kinase
dysfunction in dementia.