TRADITIONAL POSTER - ismrm

Poster Sessions
1183. Examining Structure and Function in a Cognitive Task
Jeffrey Thomas Duda 1 , Corey McMillan, Murray Grossman, James Gee
1 Bioengineering, University of Pennsylvania, Philadelphia, PA, United States
Structure and function are examined in the language network with DT-MRI and BOLD fMRI during a cognitive task. Activated cortical regions are
identified and used to determine activation levels in each subject. Additionally, the regions are used to identify fiber tracts of interest. Canonical correlation
analysis is used to identify correlations between functional activation and average fractional anisotropy in the fiber tracts. For each correlation found, the
highest weightings are found for cortical regions and a tract that connects to that region.
1184. Effects of FMRI Acoustic Scanner Noise on Neural Processing Networks During Task Performance
and Rest
Dave Langers 1 , Pim van Dijk 1
1 Otorhinolaryngology, University Medical Center Groningen, Groningen, Netherlands
Scanner acoustic noise may detrimentally affect stimulus/task-evoked neural responses in fMRI. This has been reported for the unimodal and associative
auditory systems, but also for the default mode network and other brain systems.
In the current experiment, the effects of scanner noise in resting state fMRI are studied. We find that similar independent components may be extracted with
and without background scanner noise, both during active and resting states. However, the overall strength, spatial extent, and temporal dynamics of various
neural components are affected by the presence of background noise. Our results both corroborate and extend previous findings in literature. More detailed
specific findings for various brain systems will be presented.
1185. Neural Correlates of Feigned Hearing
Bradley McPherson 1 , Wayne Wilson 2 , David Copland 3,4 , Katie McMahon 5
1 Division of Speech and Hearing Sciences, Hong Kong University, China; 2 Division of Audiology, University of Queensland,
Australia; 3 Centre for Clinical Research, University of Queensland, Australia; 4 School of Health and Rehabilitation Sciences,
University of Queensland, Australia; 5 Centre for Magnetic Resonance, University of Queensland, Brisbane, Queensland, Australia
Can we use patterns of brain activity to detect when someone is feigning a hearing loss? To answer this question, we asked 15 adult participants to respond
to pure tones and simple words correctly, incorrectly, randomly, or with the intent to feign a hearing loss.
1186. An FMRI Study of Memory Performance in Type 2 Diabetes Mellitus: A Twin Study
Amanda Wood 1 , Jian Chen 2,3 , Thanh G. Phan 2 , Kimberlea Cooper 2 , Stacey Litras 2 , Srikanth Velandai 2
1 Developmental and Functional Brain Imaging,Critical Care and Neuroscience, Murdoch Childrens Research Institute, Melbourne,
VIC, Australia; 2 Stroke and Ageing Research Group, Department of Medicine, Monash University, Melbourne, VIC, Australia;
3 Developmental and Functional Brain Imaging,Critical Care and Neuroscience , Murdoch Childrens Research Institute, Melbourne,
VIC, Australia
Type 2 Diabetes mellitus (DM) is linked to a greater risk of dementia, but the underlying mechanisms and brain regions involved are unknown. We
conducted a co-twin (DM/non DM) case-control study of fMRI activation during a visual memory task. Non DM twins showed greater activation of
temporal, parietal and occipital cortices suggesting involvement of these areas in DM pathology.
Animal fMRI
Hall B Wednesday 13:30-15:30
1187. Increased Sensitivity to the BOLD-FMRI Signal Response During Electrical Forepaw Stimulation in
Mice Using a Cryogenic RF Probe
Christof Baltes* 1 , Simone Bosshard* 1 , Thomas Mueggler 1,2 , Markus Rudin 1,3
1 Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; 2 Pharmaceutical Research Neuroscience, F.
Hoffmann-La Roche Ltd., Basel, Switzerland; 3 Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
BOLD-fMRI in mice using electrical forepaw stimulation was performed with a cryogenic transceive RF probe and a room-temperature receive-only surface
coil. The effect of the increased sensitivity of the cryogenic probe on detecting BOLD responses was analyzed. In fMRI experiments, a gain in image SNR
and in temporal SNR of a factor of 3.10 and 1.77 was found, respectively. As further optimization parameter adjusting the thermal shield temperature of the
cryogenic probe allows for altering baseline perfusion and accordingly BOLD responses. Cryogenic cooling reduces BOLD signal variations by a factor of
1.59 and therefore increases the statistical power of fMRI.
1188. Investigating Color Vision Using FMRI: Rodent Vs Primate
Andy Paul Salzwedel 1 , Matt Mauck 2 , James Kuchenbecker 3 , Chris Pawela 1 , James Hyde 1 , Maureen Neitz 3 ,
Jay Neitz 3
1 Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 2 Department of Ophthalmology, Cell Biology,
Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI, United States; 3 Ophthalmology, University of
Washington, Seattle, WA, United States
In a comparative study, the visual pathways of two different animal models (rodent vs primate) were probed using high field strength (9.4T) fMRI. The
primary goal of this research was to assay the color vision systems of these two species in hope of demonstrating the evolutionary homology thereof. Here
we present several techniques that combine to form a unique overall method for probing this pathway; pharmacological intervention (AP4), precession fMRI
compatible LED based stimuli, and intra-brain controls.