TRADITIONAL POSTER - ismrm

Poster Sessions
symptomatic patients with either 0-69% stenosis or occlusion; more than ⅓ of patients with 50-69% stenosis presented with this plaque. This subgroup of
patients could in future possibly benefit from aggressive medicinal therapy or revascularization.
2351. Comparing Magnetic Susceptibility Mapping with SWI for Targeting Structures for Deep Brain
Stimulation
Karin Shmueli 1 , Ruth O'Gorman 2,3 , David Lythgoe 4 , Michael Samuel 5 , Richard Selway 6 , Keyoumars
Ashkan 6 , Jozef Jarosz 2
1 Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke,
National Institutes of Health, Bethesda, MD, United States; 2 Department of Neuroradiology, King's College Hospital, London, United
Kingdom; 3 MR-Zentrum, University Children’s Hospital, Zurich, Switzerland; 4 Centre for Neuroimaging Sciences, Institute of
Psychiatry, King's College London, United Kingdom; 5 Department of Neurology, King's College Hospital, London, United Kingdom;
6 Department of Neurosurgery, King's College Hospital, London, United Kingdom
Susceptibility-Weighted Imaging (SWI) improves the visibility of target structures (globus pallidus (GP) and subthalamic nucleus (STN)) for deep brain
stimulation (DBS). However, because phase contrast is non-local and orientation dependent, SWI contains artifacts that may result in targeting errors.
Susceptibility maps, which have shown promise for overcoming such artifacts, were calculated from clinical 1.5-T phase data acquired at a single
orientation. 2-mm shifts in the superior borders of the red nuclei and GP in the SWI relative to the susceptibility maps were observed in several volunteers
and DBS patients showing that susceptibility mapping may help reduce SWI targeting errors.
2352. Aqueduct CSF Flow Measured Objectively with PC-MRI
Anders Wåhlin 1 , Khalid Ambarki 1 , Anders Garpebring 1 , Jan Malm 2 , Richard Birgander 1 , Anders Eklund 1
1 Radiation Sciences, Umeå University Hospital, Umeå, Västerbotten, Sweden; 2 Clinical Neuroscience, Umeå University Hospital,
Umeå, Västerbotten, Sweden
Aqueductal cerebrospinal fluid flow, measured with motion sensitive phase contrast MRI, is subject to typical imperfections in flow imaging such as partial
volume effects and difficulties in lumen delineation. In this study we abandoned graphically represented vessel delineations. Instead we used complex data
generated by the PC-MRI in a method with the potential of objective and absolute measurement of CSF velocity and area, without restrictions by matrix
resolution. We compared the complex value methodology with conventional manual segmentation for the determination of aqueduct CSF stroke volume in a
group of 42 healthy elderly.
2353. MR-Based, Subject-Specific Computational Fluid Dynamics Modeling of the Vertebro-Basilar System
Amanda Kathleen Wake 1 , John C. Gore 1 , J. Christopher Gatenby 1
1 Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States
In this study high field MR and phase contrast (PCMR) data were used to construct a subject-specific model of flow in the vertebro-basilar system. Wall
shear stress (WSS) data from the model yield insight into artery bypass graft design.
Animal Models of Brain Disease
Hall B Monday 14:00-16:00
2354. Decreased ADC Precedes Cellular Swelling in N-Methyl-D-Aspartate (NMDA) Treated Mouse Retina
Chia-Wen Chiang 1 , Junjie Chen 2 , Sheng-Kwei Song 3
1 Chemistry, Washington University in St. Louis, Saint Louis, MO, United States; 2 Medicine, Washington University in St. Louis,
Saint Louis, MO, United States; 3 Radiology, Washington University in St. Louis, Saint Louis, MO, United States
Apparent diffusion coefficient (ADC) is a widely used neuronal injury marker for early detection of various brain disorders. In the current study, we
investigated the timing of decreased ADC vs. the detectable tissue swelling resulting from N-methyl-D-aspartate (NMDA) induced cytotoxic edema in
mouse retina in vivo. Results suggest that decreased ADC is a biomarker of cytotoxic edema providing an early measure of retinal excitotoxic injury before
detectable retinal swelling.
2355. Acute & Sub-Chronic Neuronal Effects of NMDA Receptor Antagonist, Memantine Using
Pharmacological Magnetic Resonance Imaging
Sakthivel Sekar 1 , Marleen Verhoye 1 , Johan Van Audekerke 1 , Koen Tahon 2 , Koen Wuyts 3 , Claire Mackie 3 ,
Michele Giugliano 2 , Thomas Steckler 3 , Annemie Van Der Linden 1
1 Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium; 2 Theoritical Neurobiology, University of Antwerp, Antwerp, Belgium;
3 Johnson & Johnson Pharmaceuticals Research & Development, Beerse, Belgium
The present study reports on the acute and sub-chronic neuronal effects of the NMDA antagonist memantine on the rat brain measured as BOLD (blood
oxygenation level dependent) contrast changes in a pharmacological magnetic resonance imaging (phMRI) study. Corroborative investigations include
recording the spontaneous local field potential (LFP) activity in key brain regions (through electrophysiology) and the pharmacokinetics of acute and subchronic
memantine treatment in blood plasma and the brain.