TRADITIONAL POSTER - ismrm

Poster Sessions
951. In Vivo Temperature Brain Map Using Jmrui V4.X: A Plugin Development
Elena Vescovo 1 , Federico Di Cesare 2 , Dan Stefan 2 , Danielle Graveron-Demilly 2 , Steve Williams 3
1 Image Science and Biomedical Engineering,, The University of Manchester, Manchester, Greater Manchester, United Kingdom;
2 Laboratoire CREATIS-LRMN, CNRS UMR 5220, Universite' Claude Bernard Lyon 1, Lyon, France; 3 Image Science and
Biomedical Engineering, The University of Manchester, Manchester, Greater Manchester, United Kingdom
Magnetic resonance spectroscopy can provide a non-invasive approach to measure the internal temperature of the brain; it relies on the linear relationship
between the 1H MR resonance frequency of water in the tissue and the tissue’s temperature. The absolute temperature is obtained by measuring the
chemical shift of water relative to a reference compound such as N-Acetylaspartate (NAA). To convert the frequency difference between these two signals
into temperature, it is necessary to apply a calibration curve. All these procedures could be performed using a plugin of jMRUI, a Java-based Graphical User
Interface that allows time-domains analysis of MRS, MRSI and HRMS-NMR signals. In this work we used jMRUI v4.x, a new version of the software that
enabled the user to add their own plugin.
952. Efficient Generation of a Magnetic Field-Free Line
Tobias Knopp 1 , Marlitt Erbe 1 , Timo F. Sattel 1 , Sven Biederer 1 , Thorsten M. Buzug 1
1 Institute of Medical Engineering, University of Lübeck, Lübeck, Germany
Spatial encoding in magnetic particle imaging (MPI) is achieved by moving a field-free point (FFP) through the imaging volume. Recently, it was shown
that the sensitivity of MPI can be increased by taking advantage of a field-free line (FFL) for spatial encoding. However, until today the power loss of an
FFL scanner was thousand times higher than the power loss of an FFP scanner. In this work, the first feasible coil setup is presented, which has a power loss
of the same order as an FFP scanner.
953. Relaxation Enhancement by Longitudinal Multispin Orders
Loyola D'Silva 1 , S. Sendhil Velan 1
1 Laboratory for Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore
There is a great interest in increasing the longitudinal relaxation of nuclear spins for hyperpolarized imaging experiments. Longitudinal multispin orders
(LOMO) correspond to the non-equilibrium population distribution and can be created in spin systems that exhibit J couplings, dipolar couplings or
quadrupolar couplings. It can also be created via cross-correlated relaxation between different relaxation pathways present for the given spin system. A two
fold increase in longitudinal magnetization is achieved using the frequency cycling approach.
954. Improved Estimation of the Magnetic Nanoparticle Diameter with a Magnetic Particle Spectrometer
and Combined Fields
Sven Biederer 1 , Tobias Knopp 1 , Timo Frederik Sattel 1 , Marlitt Erbe 1 , Thorsten M. Buzug 1
1 Institute of Medical Engineering, University of Luebeck, Luebeck, Germany
In Magnetic Particle Imaging the iron-core size distribution is a very important criterion for the imaging quality as well as for a model based reconstruction.
An estimation of such a distribution is possible by using magnetization spectra of a Magnetic Particle Spectrometer. In this contribution a method is
presented to improve the condition of the minimization problem. For this purpose offset fields are added to the sinusoidal excitation of the Magnetic Particle
Spectrometer. This leads to a more stable and robust estimation of the iron-core size distribution.
955. Assignment of the NMR 2 H Double Quantum Filtered Signals in Nerves and Spinal Cords to Their
Anatomical Compartments
Hadassah Shinar 1 , Tal Ben -David 1 , Uzi Eliav 1 , Gil Navon 1
1 School of Chemistry, Tel Aviv University, Tel Aviv, Israel
2 H double quantum filtered (DQF) NMR of nerves and spinal cords enabled the assignment of the different signals to their anatomical compartments. In
nerves the signals with the quadrupolar splittings of approximately 1500, 500, and 200 Hz were assigned to the water in the epineurium, myelin sheaths and
endoneurium respectively. A narrow signal was also observed and assigned to intraaxonal water. In spinal cords only the 500 Hz satellites and the narrow
signal were detected. The assignment was based on a series of experiments including the effects of collagenase, stretching, Wallerian degeneration, diffusion
and was corroborated by histology. <
956. In Vivo Proton MR Spectroscopic ( 1 H-MRS) Investigations of Metabolic Changes in Human Brain
Associated with Unspecific Low Back Pain
Alexander Gussew 1 , Reinhard Rzanny 1 , Hans Christoph Scholle 2 , Juergen R. Reichenbach 1
1 Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital, Jena, Germany; 2 Division
Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstruc, Jena University Hospital, Jena,
Germany
In vivo 1 H-MRS detection of metabolic changes associated with chronic pain may provide deeper understanding of biochemical neuronal dysfunctions
caused by chronification and may potentially help to specify therapeutic approaches. In this study absolute concentrations of metabolites N-acetyl aspartate,
creatine, total choline, myo-Inositol and glutamate were measured by single voxel 1 H-MRS at 3 T in anterior insular, anterior cingulate cortex and thalamus
of six patients with chronic low back pain and corresponding healthy controls. In all investigated brain regions, concentration decrease of all metabolites up
to 36% was observed in patients.