TRADITIONAL POSTER - ismrm

Poster Sessions
1878. Lipid-Coated Iron Oxide: A Versatile, Biocompatible and Multimodal Material for Cellular Imaging
Geralda A.F. van Tilborg 1 , Willem J.M. Mulder 2 , Susanne M.A. van der Pol 3 , Louis van Bloois 4 , Annette
van der Toorn 1 , Gert Storm 4 , Helga E. de Vries 3 , Rick M. Dijkhuizen 1
1 Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 2 Translational and Molecular Imaging Institute, ,
Mount Sinai School of Medicine, New York, United States; 3 Department of Molecular Cell Biology and Immunology, VU University
Medical Center, Amsterdam, Netherlands; 4 Department of Pharmaceutics, Institute for Pharmaceutical Sciences, Utrecht, Netherlands
In this study we propose a novel lipid-coated fluorescent iron oxide particle for simultaneous magnetic and fluorescent cell labeling. Murine macrophages
(RAW) were incubated with the contrast agent and showed efficient labeling without inducing toxicity. Labeled cells were clearly detected with T2-
weighted MRI, fluorescence microscopy and flow cytometry. The presented nanoparticulate agent represents a versatile and potent contrast material for
cellular imaging, and can be particularly attractive for assessing the fate of in vivo administered labeled cells with multimodal imaging techniques.
1879. Towards in Vivo Visualization of Pancreatic Beta-Cells in the Mouse: Molecular Imaging at 16.4 T
Sven Gottschalk 1 , Dávid Zsolt Balla 1 , Rolf Pohmann 1 , Jörn Engelmann 1
1 High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany
Despite of decade-long research, no method exists that could either accurately or non-invasively determine the pancreatic beta-cell mass in vivo. We present
in vivo MRI of the mouse pancreas at ultra high fields (16.4T) and the first attempt to visualize pancreatic islets with a newly developed beta-cell specific
contrast agent. Structures