TRADITIONAL POSTER - ismrm

Poster Sessions
2293. Attachment Model Affects Brain Responses in Areas Related to Empathy and Maternal Behaviour
Delia Lenzi 1,2 , Cristina Trentini 3 , Patrizia Pantano 1 , Emiliano Macaluso 2 , Gian Luigi Lenzi 1,4 , Massimo
Ammaniti
1 Dipartimento di Scienze Neurologiche, Università di Roma "Sapienza", Roma, Italy; 2 Neuroimaging Laboratory, Fondazione Santa
Lucia, Roma, Italy; 3 Department of Dynamic and Clinical Psychology, Università di Roma "Sapienza", Roma, Italy; 4 Centro per lo
Studio delle Funzioni Mentali dellâ€Uomo, Università di Roma "Sapienza", Rome, Italy
Within the Attachment theory , Securely attached people tend to have positive views of themselves and their relationships. They feel comfortable with
intimacy and independence, balancing the two in their relationships. Dismissive-avoidant adults tend to suppress and hide their feelings, dealing with
rejection by distancing themselves from partners. Using fMRI we show that Dismissive subjects during the observation of stimuli activating attachment and
maternal feelings have a overall greater reaction when compared to Secure subjects, i.e. greatly activate areas related to empathy and emotions (mirror
neuron and limbic system) and inhibit areas related to maternal behaviour (anterior cingulated cortex).
2294. Differences of Functional Activation Patterns Between Subjects with Mild Cognitive Impairment and
Normal Subjects
Mingwu Jin 1 , Victoria Pelak 2 , Tim Curran 3 , Marie Banich 3 , Rajesh Nandy 4 , Dietmar Cordes 1
1 C-TRIC and Radiology, University of Colorado Denver, Aurora, CO, United States; 2 Neurology, University of Colorado Denver,
Aurora, CO, United States; 3 Institute of Cognitive Science, University of Colorado at Boulder, Boulder, CO, United States;
4 Biostatistics and Psychology, UCLA, Los Angeles, CA, United States
Functional MRI (fMRI) is an important imaging modality to reveal altered function in neurodegenerative diseases. We hypothesize that functional changes
in activation occur earlier and can be measured before structural degeneration is obvious. FMRI can potentially lead to an imaging marker for the early
diagnosis of mild cognitive impairment (MCI) and furthermore may predict the development of Alzheimer’s disease (AD). In this work, we present fMRI
results of 8 MCI and 8 normal subjects using different memory paradigms.
2295. Functional Connectivity in Resting State CBF Mapping in Postherpetic Neuralgia
Jing Liu 1 , Yue Zhang 2 , XiaoYing Wang 3 , MinYi Du 4 , Jue Zhang 2
1 Department of Radiology, Peking University First Hospital , BeiJing, China; 2 College of Engineering, Peking University, BeiJing,
China; 3 Department of Radiology, Peking University First Hospital, BeiJing, China; 4 Department of Anaesthesiology, Peking
University First Hospital, BeiJing, China
Given the poor specificity and reproducibility of blood oxygenation level dependent(BOLD), we use cerebral blood flow for the first time to build restingstate
networks of default mode both in patients suffering from postherpetic neuralgia and healthy subjects, and compare the two groups. The results of
functional connectivity in healthy subjects showed that the areas activating were the same with the parts previously described in the literatures using BOLD.
The results between-groups comparison showed that some parts were in strengthened correlation of posterior cingulate cortex in patients, such as anterior
cingulated cortex and insula which are related to pain.
2296. Identification of Hyperactive Intrinsic Amygdala Network Associated with Impulsivity in Abstinent
Heroin Addicts
Chunming Xie 1 , Liping Fu 2 , Lin Ma 3 , Wenjun Li 1 , Alex Cohen 1 , Zheng Yang 2 , Shi-Jiang Li 1
1 Medical College of Wisconsin, Milwaukee, WI, United States; 2 Beijing Institute of Basic Medical Science, Beijing, China;
3 Department of Radiology, The PLA General Hospital, Beijing, China
The purpose of this study was to investigate the neuropsychological underpinnings of impulsive network on abstinent heroin addicts using resting-state
functional connectivity method. Heroin subjects showed the higher impulsive scores and abnormal amygdala networks activity. The altered amygdala
network strengths significantly correlated with impulsivity, and different correlation patterns were fund in heroin subjects relative to control subjects. This
finding indicated the neural constructs of impulsive network was different in these two group subjects and altered amygdala network activity in heroin
subjects makes a critical contribution to the impulsive dysfunction and represents the pathological damage underlying the impulsive control.
2297. Changes in Glutamate Levels After an FMRI Experiment
Paul G. Mullins 1 , Niklas Ihssen 1 , David Linden 1 , Miles Cox 1
1 Psychology, Bangor University, Bangor, Gwynedd, United Kingdom
MRS measures of brain chemistry are often considered static snapshots. We present MRS data showing an increase in Glutamate levels in the anterior
cingulate cortex from baseline after a cognitive fMRI task. The biologic and methodologic implications of these findings are discussed.
2298. Development of a 17.6T Ultra-High Field BOLD-FMRI Method for Amygdala Related Psychiatric
Disorders
Markus Friedrich Hildenbrand 1 , Stephan Nauroth 2 , Xavier Helluy 1 , Philipp Moerchel 3 , Angelika Schmitt 2 ,
Klaus-Peter Lesch 2
1 Research Center Magnetic Resonance Bavaria (MRB), Wuerzburg, Germany; 2 Department of Psychiatry, University of Wuerzburg,
Germany; 3 Department of Experimental Physics 5, University of Wuerzburg, Germany
For psychiatric disorders being a worldwide strain to individuals and the health care systems and still being without comprehensive therapies, the mouse as
model organism is a very promising research approach. Based on the development of a 17.6T ultra-high field BOLD-fMRI method for targeting the
amygdala in the mouse brain, an access to serotonin mediated psychiatric diseases has been accomplished. By the usage of predator odor the activation of the
amygdala shows a high sensitivity and specificity which yields a very good observation of the location and time devolution of the stimulus in the amygdala
over a specified time period.