TRADITIONAL POSTER - ismrm

Poster Sessions
2130. Relationship Between Serum Inflammatory Markers, Regional Brain Volumes, and Perfusion in Older
Diabetic Subjects
Peng Zhao 1 , Vera Novak 1 , Kun Hu 1 , Medha Munshi 1 , David Alsop 2 , Amir Abduljalil 3 , Peter Novak 4
1 Gerontology, Beth Israel Deaconess Medical Center, Boston, MA, United States; 2 Radiology, Beth Israel Deaconess Medical Center,
Boston, MA, United States; 3 Radiology, Ohio State University, Columbus, OH, United States; 4 Neurolgoy, University of
Massachusetts Medical School, Worcester, MA, United States
Type 2 DM is a major risk factor for both large and small vessel atherosclerosis, stroke, and vascular dementia. Hyperglycemia is a common mechanism of
endothelial dysfunction and neuronal cell damage. Microvascular disease manifests as white matter hyperintesities on MRI, regional atrophy and functional
decline. Inflammation further affects microcirculatory regulation and contributes to arteriolosclerosis. We investigated the effects of inflammation on
regional perfusion and neurodegenerative changes in grey and white matter on MRI. Inflammatory markers had different effects on regional brain volumes.
sICAM was associated with atrophy across all regions in the DM group, with the most significant effects in the frontal and parietal regions. In the control
group, regional perfusion on both sides in the parietal lobe is positively correlated with sICAM, and perfusion in the right occipital lobe is positive with
sVCAM. Associations between regional brain volumes and other inflammatory markers were not prominent. Frontal and parietal regions with high energy
demands are more vulnerable to the effects of DM in the brain.
2131. Quantification of Frontal Glutamate Neurotranmission in Human HIV
Napapon Sailasuta 1 , Kimbery Shriner 2 , Kent Harris 1 , Thao T. Tran 1,3 , Osama Abulseoud 4 , Brian D. Ross 1,5
1 Clinical MR Spectroscopy, Huntington Medical Research Institutes, Pasadena, CA, United States; 2 The Phil Simon Clinic,
Huntington Memorial Hospital, Pasadena, CA, United States; 3 Rudi Schulte Research Institute, Santa Barbara, CA, United States;
4 University of Southern California, Keck School of Medicine, Los Angeles, CA, United States; 5 Rudi Schulte Research Institute,
Santa Barbara , CA, United States
Despite successful treatment of HIV and AIDS, neuroimaging and neurospectroscopy abnormalities persist suggesting residual viral effects or unwanted
neurological side effects of effective therapies. Elucidation of the recently described reduction in frontal lobe glutamate concentration in white matter of
HIV-affected individuals requires independent 13C MRS measurement of glutamate turnover neurotransmitter rates in neurons and glia. This study
develops the necessary frontal lobe assay of neuronal and axonal glutamate turnover by infusion of 2-13C glucose followed by low-power nOe 13C MRS in
HIV and normal control subjects. Preliminary results indicate reduced 13C glutamate turnover in successfully treated HIV.
2132. Proton MR Spectroscopy Findings in Chronic Neuroborreliosis
Caitlin Judith Hardy 1 , Amit Gokhale 2 , David Younger 2 , Nissa Perry 2 , Oded Gonen 2
1 Radiology, NYU, New York, NY, United States; 2 NYU School of Medicine
Abnormal metabolite levels were found in 3/3 patients with a diagnosis a post Lyme disease syndrome using 1H-MRS.
Animal Models of White Matter Disease
Hall B Wednesday 13:30-15:30
2133. Vascular Endothelial Growth Factor - A Novel Player in SCI Pain
Laura Sundberg 1 , Juan Herrera 1 , Olivera Nesic 2 , Ponnada Narayana 1
1 Diagnostic and Interventional Imaging, The University of Texas Medical School, Houston, TX, United States; 2 Biochemistry and
Molecular Biology, University of Texas Medical Branch, Galveston, TX, United States
Vascular endothelial growth factor (VEGF) has been investigated as a potential treatment for spinal cord injury (SCI) due to its vascular-promoting and
neuroprotective effects; however, studies have provided conflicting information about the post-SCI effects of VEGF. In this study, VEGF was delivered
immediately after SCI and longitudinal MRI and behavioral studies were performed into the chronic phase of injury. It was found that VEGF treatment
results in tissue sparing and increased markers of neurofilament, but many animals also displayed a higher incidence of mechanical allodynia. VEGF may
spare tissue, but may also encourage non-specific sprouting of axons into pain pathways.
2134. Viscoelastic Properties Change at an Early Stage of Cuprizone Induced Affection of Oligodendrocytes
in the Corpus Callosum of C57/black6 Mice
Katharina Schregel 1 , Eva Wuerfel 1 , Jens Wuerfel 1 , Dirk Petersen 1 , Ralph Sinkus 2
1 University of Luebeck, Luebeck, Germany; 2 Institut Langevin, ESPCI, Paris, France
MRE is an innovative imaging technique developed to non-invasively map and quantify the viscoelastic properties of tissue in vivo. As pathological
alterations cause changes in elasticity and viscosity, MRE might be applied to characterize the structural integrity of given tissues and could be employed for
diagnosis and clinical monitoring of neurodegenerative diseases such as multiple sclerosis. Therefore it appears to be essential to evaluate the effect of
pathological processes occurring in multiple sclerosis on the viscoelastic properties of cerebral tissue with the help of experimental rodent models. We
introduced the cuprizone mouse-model (C57/black6) which depicts key features of multiple sclerosis.
2135. Hybrid Diffusion Imaging in a Spinal Cord Model of Dysmyelination
A P. Hosseinbor 1 , I D. Duncan 2 , A L. Alexander, A A. Samsonov 3 , Y-C Wu 4 , S A. Hurley, R A. Fisher, A S.
Field 3
1 Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 2 Medical Sciences, University of Wisconsin-
Madison; 3 Radiology, University of Wisconsin-Madison; 4 Dartmouth College
The shaking pup (shp) is a canine mutant model of dysmyelination, and suffers from severe myelin deficiency. In a previous study of shp brain, Po was
shown to differentiate between a control and diseased pup with respect to myelin content. In this study, WM integrity is examined in the spinal cord of shp