TRADITIONAL POSTER - ismrm

Poster Sessions
Recent ex vivo studies of carotid plaques found that DWI could detect lipids and hemorrhage with greater sensitivity than other MRI. This study reports the
ADC values of lipid, hemorrhage and overall wall composition as measured with in-vivo DWI, with histology used as the basis for comparison
1271. High Resolution 3D Carotid Plaque Perfusion Mapping and Its Association with T2 Hyperintensity
Michael Jerosch-Herold 1 , YiuCho Chung 2 , Ravi Teja Seethamraju 3 , Otavio R. Coelho-Filho 4 , Marcelo
Fernando Di Carli, Peter Libby, Raymond Y. Kwong
1 Radiology, Brigham & Women's Hospital, Boston, MA, United States; 2 MRI, Siemens Medical Systems, Columbus, OH, United
States; 3 Siemens Medical Systems, Boston, MA, United States; 4 Brigham & Women's Hospital, United States
The transfer rate (Ktrans) of gadolinium contrast into the extracellular space is a validated marker of carotid plaque neo-vascularization and inflammation.
T2-weighted imaging is a complementary marker of inflammation in vessel wall and plaque. The association between Ktrans and increased SI on T2 images
of carotid plaque was investigated in this study by high resolution, 3D dynamic T1w gradient echo imaging, and a 3D T2w TSE method (T2-SPACE).
Ktrans and T2-signal hyper-enhancement were found to be strongly associated markers of neo-vascularization and inflammation, respectively.
1272. In Vivo Characterization of a New Abdominal Aortic Aneurysm Mouse Model with Conventional and
Molecular MRI
Ahmed Klink 1 , Joeri Heynens 2 , Beatriz Herranz 3 , Hendrik M. Sanders 2 , Gustav J. Strijkers 2 , Klaas
Nicolay 2 , Maarten Merkx, Ziad Mallat 4 , Willem J.M. Mulder 1 , Zahi A. Fayad 1
1 Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY, United States; 2 Biomedical NMR,
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 3 Vascular Imaging and
Atherothrombosis, CNIC, Madrid, Spain; 4 Paris Cardiovascular Research Center, INSERM, U689, Paris, France
The in vivo characterization of a novel mouse model of abdominal aortic aneurysm (AAA) was achieved with both multi-contrast MRI (PDW, T2W, T1W,
TOF) and collagen-targeted MR molecular imaging. The latter was performed with fluorescent/paramagnetic micelles conjugated to the collagen-specific
protein CNA35. This allowed the imaging of the collagen turnover believed to be key in AAA progression and rupture. We established that these MRI tools
were very valuable for the longitudinal investigation of AAA progression in this mouse model of AAA.
1273. Carotid Artery Wall Lipid Quantification by Means of 1H-Magnetic Resonance Spectroscopy:
Correlation with Carotid Wall Area and Normalized Wall Index.
Raphael Duivenvoorden 1 , Adriaan G. Holleboom 1 , Eric de Groot 1 , Dirkjan F. Enklaar 1 , Johan S. Laméris 2 ,
John J.P. Kastelein 1 , Erik S.G. Stroes 1 , Aart J. Nederveen 2
1 Vascular Medicine, Academic Medical Center, Amsterdam, NH, Netherlands; 2 Radiology, Academic Medical Center, Amsterdam,
NH, Netherlands
We developed a carotid MRS protocol to non-invasively test the relation between the lipid to water ratio at the location of the carotid artery wall and carotid
artery wall dimensions. We found that the lipid:water ratio correlated with the carotid artery wall dimensions, independent of serum lipid levels. Further
research is needed to resolve whether MRS is a useful tool to assess the efficacy of lipid altering pharmacotherapy in the treatment of advanced
atherosclerotic lesions.
1274. Efficient Flow Suppressed MRI Improves Reproducibility of Carotid Atherosclerosis Plaque Burden
Measurements
Li Dong 1 , Jinnan Wang 2 , Vasily Yarnykh 1 , Hunter Underhill 1 , Moni Neradilek 3 , Thomas Hatsukami 1 , Chun
Yuan 1
1 University of Washington, Seattle, WA, United States; 2 Philips Research North America; 3 The Mountain-Whisper-Light Statistics
Previous studies found that a turbo spin-echo based motion-sensitized driven-equilibrium (MSDE) sequence, provides more efficient residual flow signal
suppression than the widely used multislice double inversion recovery (mDIR). However, whether this improved flow-suppression can improve
reproducibility in atherosclerotic burden measurement is unknown. Bilateral carotid arteries (n=36) from 18 asymptomatic subjects underwent two carotid
MRI examinations within 12 days. Compared to mDIR, the MSDE technique had a significantly reduced inter-scan reproducibility for lumen and wall area.
For future clinical trials using carotid MRI, improved flow suppression techniques is recommended to monitor progression or regression of atherosclerosis
plaque burden.
1275. Femoral Artery Vessel Wall Imaging Using Contrast-Enhanced, Susceptibility Weighted Imaging
Qi Liu 1 , Zhaoyang Fan 1 , Qi Yang 2 , E Mark Haacke 3 , Debiao Li 1
1 Departments of Radiology and Biomedical Engineering, Northwestern University, Chicago, IL, United States; 2 Xuanwu Hospital,
Beijing, China; 3 Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States
By using a gradient-echo sequence with a relatively long echo time with flow compensation, together with proper post processing to preserve tissue
susceptibility property while removing unwanted phase aliasing, arterial wall delineation was achieved in SWI phase images. To further enhance the lumenwall
contrast in phase images, we hypothesized that by injecting contrast agent which is known to alter blood susceptibility, more pronounced lumen-wall
contrast could be obtained. Our contrast-enhanced SWI study on volunteers has confirmed the above hypothesis and observed substantial increase in lumenwall
phase contrast.
1276. Zoom Imaging for Cardiovascular Risk Assessment
Tarique Hussain 1 , Rachel Clough 1 , Gerald Greil 1 , Rene Botnar 1
1 Division of Imaging Sciences, King's College London, London, United Kingdom
In this study we applied the restricted field-of-view (FOV) zoom imaging technique for the reduction of scan time in diagnostic turbo-spin-echo (TSE) black
blood aortic vessel wall imaging. Images were compared to a full FOV vessel wall acquisition and image quality was assessed.