TRADITIONAL POSTER - ismrm

Poster Sessions
Brain Tumor Imaging: Diffusion, MRS & High-Field Imaging
Hall B Wednesday 13:30-15:30
2197. Assessment of Invasion and Recurrence in Glioblastoma Multiforme Using Diffusion Weighted MRI
Edge Characteristics of Contrast Enhancing Tumor
Peter Sherman LaViolette 1,2 , Benjamin M. Ellingson, 2,3 , Jennifer M. Connelly, 2,4 , Mark G. Malkin, 2,4 , Scott
D. Rand, 2,3 , Kathleen M. Schmainda 1,2
1 Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 2 Translational Brain Tumor Program, Medical College of
Wisconsin, Milwaukee, WI, United States; 3 Radiology, Medical College of Wisconsin, Milwaukee, WI, United States; 4 Neurology,
Medical College of Wisconsin, Milwaukee, WI, United States
Traditionally, brain tumor recurrence is defined as new MRI contrast enhancement apparent in follow-up imaging. This study shows that diffusion weighted
MRI edge characteristics of contrast enhancing tumors show measurable differences indicative of tumor invasion prior to contrast enhancing recurrence
2198. Determination of Structural Differences Between Glioblastomas and Metastases by Diffusion Kurtosis
Imaging
Peter Raab 1,2 , Elke Hattingen 2 , Kea Franz 3 , Friedhelm E. Zanella 2 , Heinrich Lanfermann 1,2
1 Neuroradiology, Hannover Medical School, Hannover, Germany; 2 Neuroradiology, JW Goethe University, Frankfurt/Main,
Germany; 3 Neurosurgery, JW Goethe University, Frankfurt/Main, Germany
Diffusion kurtosis imaging evaluates the non-Gaussian diffusion pattern of water and indicates tissue structure complexity. In this diffusion study we found
differences between glioblastomas and cerebral metastases, that indicate more directed diffusion in glioblastomas and a higher structural complexity in
metastases.
2199. Fiber Density Mapping in Patients with Gliomas: Histopathologic Evaluation of a Novel Approach for
Post-Processing of DTI Data
Andreas Stadlbauer 1,2 , Michael Buchfelder 2 , Oliver Ganslandt 2
1 MR Physics Group, Department of Radiology, Landesklinikum St. Poelten, St. Poelten, Austria; 2 Department of Neurosurgery,
University of Erlangen-Nuremberg, Erlangen, Germany
To histopathological evaluate fiber density mapping (FDM) in glioma patients for assessment of the extent of destruction of white matter structures in the
center, the transition zone and the border zone of gliomas. We correlated FDM-data and histopathological findings from 78 stereotactic biopsies of 20
glioma patients. We found a negative logarithmic correlation of fiber-density with both, % tumor infiltration and tumor cell number. For a tumor infiltration
of >60% no fibers are remaining. In tumor regions with