TRADITIONAL POSTER - ismrm

Poster Sessions
2116. A Three-Dimensional Multi-Scale Line Filter Algorithm for Segmentation of Vein Vessels in
Susceptibility Weighted Images
Guy U. Poloni 1,2 , Michael G. Dwyer 1 , Niels Bergsland 1 , Claudiu V. Schirda 1 , Stefano Bastianello 2 , Robert
Zivadinov 3,4
1 Buffalo Neuroimaging Analysis Center, Buffalo, NY, United States; 2 Neuroradiology Unit, Fondazione “Istituto Neurologico
Casimiro Mondino” IRCCS, Pavia, Italy; 3 Buffalo Neuroimaging Analysis Center, Buffalo , NY , United States; 4 The Jacobs
Neurological Institute, University at Buffalo, Buffalo, NY, United States
SWI is a MRI application that can directly image cerebral veins through the use of phase information to enhance local susceptibility. The present work
introduces an algorithm, based on a 3-dimensional linear filter, for segmenting and measuring vein vessels in the brain and for classifying vessels according
to their diameter. The resultant multi-scale line-filtered images provide significantly improved segmentation and visualization of curvilinear structures, in
particular with respect to small vessels, contributing to the quantitative investigation of vascular impairment in the pathologies of the central nervous system.
White Matter Diseases
Hall B Tuesday 13:30-15:30
2117. MR Relaxometry and Diffusion Tensor Imaging of Normal Appearing White Matter in Mild
Traumatic Brain Injury.
Christopher James Andrew Cowie 1,2 , Benjamin S. Aribisala 1 , Jiabao He 1 , Joshua Wood 1 , Alexander David
Mendelow 2 , Patrick Mitchell 2 , Andrew M. Blamire 1
1 Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, Tyne & Wear, United Kingdom; 2 Department
of Neurosurgery, Newcastle General Hospital, Newcastle upon Tyne, Tyne & Wear, United Kingdom
Mild traumatic brain injury (mTBI) is associated with long term cognitive and affective symptoms. Findings on conventional MRI often do not account for
the duration and severity of these symptoms. The aim of this study was to ascertain whether MR relaxometry and diffusion tensor imaging would reveal
abnormalities in normal appearing white matter (NAWM) in patients with mTBI. Whole group analysis showed no significant differences, but after grouping
the patients according to the side of the visible lesion, a significant increase in the mean diffusivity (MD) of ipsilateral frontal lobe NAWM was
demonstrated.
2118. Quantification of DTT Metrics in Various Fiber Bundle in Patients with Frontal Lobe Injury and Its
Correlation with Neuropsychological Tests
Manoj Kumar 1 , Deepa Pal 1 , Ram KS Rathore 2 , Bal K. Ojha 3 , Anil Chandra 3 , Raj Kumar 3 , Rakesh Kumar
Gupta 1
1 Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 2 Mathematics and
Statistics, Indian Institute of Technology, , Kanpur, Uttar Pradesh, India; 3 Neurosurgery, Chhatrapati Shahuji Maharaj Medical
University,, Lucknow, Uttar Pradesh, India
Diffusion tensor imaging (DTI) was performed within 7 days and after 6 months of injury in 21 traumatic brain injury (TBI) patients with frontal lobe injury
and 21 age/sex matched controls. Diffusion tensor tractography (DTT) was proposed for quantification of various white matter (WM) tracts in patients with
frontal lobe injury to assess diffuse axonal injury (DAI) and to look for correlation of these fiber bundles measures with various neuropsychological tests
(NPT). We found reduced fractional anisotropy (FA) and increased mean diffusivity (MD) values in all WM tracts in TBI patients compared to controls,
NPT scores were found to be significantly impaired in follow-up patients compare to controls and some of these tests showed significant correlation with
DTI indices with different WM tracts. WM tracts which show significant difference on DTT were also correlated with those NPT which are associated with
main function of frontal lobe such as memory, attention, visual and motor function. It appears more realistic methods for DAI quantification in TBI patients
and provides information about structural integrity and connectivity of whole fiber tracts.
2119. White Matter Degradation in Fornix After Mild Traumatic Brain Injury: Cross-Sectional and
Longitudinal MRI Investigations
Wang Zhan 1 , Grant Gauger 2 , Lauren Boreta 1 , Gary Abrams 2 , Karl Young 1 , Yu Zhang 1 , Marzieh
Nezamzadeh 1 , Norbert Schuff 1 , Michael W. Weiner 1
1 Radiology and Medical Imaging, University of California, San Francisco, San Francisco, CA, United States; 2 VA Medical Center,
San Francisco
Fornix is one of the primary white matter structures of the limbic system, and its damage in mild traumatic brain injury (TBI) may explain the memory and
learning dysfunctions in the post-concussion syndrome. N=24 TBI patients were longitudinally studied in two time points using T1 anatomical imaging and
diffusion tensor imaging (DTI) to measure the fornix-to-brain ratio (FBR) and WM integrity of fornix, and compared with matched healthy controls. Our
data show that the WM degradation in fornix onset in the acute stage after mild TBI, and that this degradation continued during the following 6-month
period of recovery.