TRADITIONAL POSTER - ismrm

Poster Sessions
2120. Detection of Tissue Changes in Traumatic Brain Injury Patients Using Automatic Regional Analysis of
Quantitative MR Scans
Benjamin Segun Aribisala 1 , Christopher J.A. Cowie 1,2 , Jiabao He 1 , Joshua Wood 1 , David A. Mendelow 2 ,
Patrick Mitchell 2 , Andrew M. Blamire 1
1 Institute of Cellular Medicine, Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, England, United
Kingdom; 2 Department of Neurosurgery, Newcastle General Hospital, Newcastle University, Newcastle upon Tyne, England, United
Kingdom
Traumatic head injury is one of the major causes of neurological morbidity and mortality in the UK with more than 0.1 million admissions per year with
primary diagnosis of head injury. This constitutes a huge drain on medical resources. Majority of these patients have ongoing symptoms which do not
correlate with MRI or CT findings. Here we investigated a cohort of patients with mild TBI using multi-parametric real space analysis. Our results show
that a fully automatic real space method of analysing quantitative MR parameters can be used to detect changes in normal appearing tissues in patients
suffering mild TBI.
2121. Using Jacobean Determinants to Map Within-Subject Serial Changes in Brain Volume in Difficult
Contexts: Implementation in Traumatic Brain Injury with Decompressive Craniectomy
Steve Sawiak 1 , Virginia FJ Newcombe 2 , M G. Abate 2 , Jo G. Outtrim 2 , John D. Pickard 1 , T A. Carpenter 1 ,
Guy B. Williams 1 , David K. Menon 2
1 Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom; 2 Division of Anaesthesia,
University of Cambridge, Cambridge, Cambridgeshire, United Kingdom
Atrophy is common post traumatic brain injury (TBI) and may correlate with outcome. We hypothesised that quantification of Jacobian determinants could
assess progressive changes in brain volume in within subject analyses, even in contexts that produce major problems with comparative analyses. We show
implementation of the approach in a single TBI subject with serial scans before and up to 12 months after decompressive craniectomy, compared to results
from healthy controls. The results indicate it is possible to monitor the changes in brain volume over time post TBI in an individual.
2122. The Relationship of White Matter Lesion and Contract Enhanced Lesion Development Courses in
Radiation Induced Brain Injury: An MRI Based Study
H Huang 1,2 , M Deng 1 , S F. Leung 3 , Y L. Chan 1 , D K. Yeung 1 , H C. Chan 1 , A T. Ahuja 1 , Y X. Wang 1
1 Department of Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin,
NT, Hong Kong; 2 Department of Radiology, The Shenzhen Third People’s Hospital, Shenzhen, China; 3 Department of Clinical
Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital
The natural course of radiation induced brain injury still remains poorly understood. Among the abnormalities white matter edema-like lesions (WML) and
contrast enhanced necrotic lesions (CEL) have been most commonly reported. It was recently reported that radiation induced brain injury was not always an
irreversible and progressive process, but one that could show regression and resolution. In total 22 nasopharyngeal carcinoma patients with 36 lobes
displaying WML and CEL were analysed in this study. The preliminary results of this study suggest the development of WML and CEL tend to follow the
same pattern, and not develop in the opposite direction.
2123. Dynamic Susceptibility Contrast Mr Perfusion Imaging of the Brain in X-Linked
Adrenoleukodystrophy
Otto Rapalino 1 , Mara Kunst 1 , Patricia Musolino 2 , Florian Eichler 2,3
1 Radiology, Massachusetts General Hospital, Boston, MA, United States; 2 Neurology, Massachusetts General Hospital, Boston, MA,
United States; 3 Martinos Center for Biomedical Imaging, Charlestown, MA, United States
Dynamic Susceptibility Contrast (DSC) MR perfusion was used to characterize the perfusion abnormalities in patients with adrenoleukodystrophy and
adrenomyeloneuropathy. This study demonstrates that the combination of conventional MR and DSC perfusion MR techniques allows the definition of five
different zones with characteristic profiles of abnormal signal and perfusion in patients with adrenoleukodystrophy that correspond to the zonal anatomy
previously described on pathological studies. These findings can be helpful in predicting disease progression, selecting patients for therapeutic interventions
and elucidating the pathophysiology of this disorder.
2124. Diffusion Tensor Imaging Detects Abnormalities in the Corticospinal Tract of the Brain in Patients
with Adrenomyeloneuropathy
Aliya Gifford 1 , Anna Binstock 2 , Joseph Wang 3 , Kathy Zackowski 3,4 , Jonathan Farrell 5,6 , Peter C.M. van
Zijl 5,6 , Gerald Raymond 1,4 , Seth Smith 7,8
1 Department of Neurogenetics, Kennedy Krieger Institute, Baltimore, MD, United States; 2 University of Maryland School of
Medicine, Baltimore, MD; 3 Motion Analysis Laboratory, Kennedy Krieger Institute, Baltimore, MD; 4 Department of Neurology,
Johns Hopkins University School of Medicine, Baltimore, MD; 5 Department of Radiology, Johns Hopkins University School of
Medicine, Baltimore, MD; 6 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD;
7 Vanderbilt University Institute of Imaging Science, United States; 8 Department of Radiology, Vanderbilt University, Nashville, TN
Adrenomyeloneuropathy (AMN) is characterized by primary distal axonopathy with secondary demyelination. In this study we performed diffusion tensor
imaging (DTI) at 1.5T on 29 healthy volunteers and 39 AMN patients. Tractography of the left and right corticospinal tracts (CST) were performed and
diffusion anisotropy and diffusivity were computed. A significant change in FA and perpendicular diffusivity was found from the pons to mid-brain
(p