TRADITIONAL POSTER - ismrm

Poster Sessions
1315. Myocardial BOLD Imaging at 3T Using Quantitative T2: Application in a Myocardial Infarct Model
Nilesh R. Ghugre 1 , Venkat Ramanan 1 , Mihaela Pop 2 , Yuesong Yang 1 , Jennifer Barry 1 , Beiping Qiang 1 , Kim
Connelly 3 , Alexander J. Dick 1 , Graham A. Wright 1,2
1 Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 2 Department of Medical Biophysics, University of
Toronto, Toronto, ON, Canada; 3 Division of Cardiology, St. Michael's Hospital, Toronto, ON, Canada
Coronary vasodilatory dysfunction has been shown in infarcted as well as remote myocardium in patients with acute coronary syndrome. Our study
demonstrates the utility of T2-based BOLD effect in probing regional and longitudinal fluctuations in vasodilatory function in a porcine model of myocardial
infarction at 3T. T2 measurements were performed in remote and infarcted myocardium at rest and after Dipyridamole-induced vasodilation (stress).
Experimental observations indicated that T2 at 3T offers greater sensitivity towards detecting changes in myocardial oxygenation compared to 1.5T,
consistent with a two-compartment theoretical model. Stress-induced vasodilatory response using quantitative T2 can help evaluate remote-zone vascular
function and potentially identity salvageable myocardium in the infarct zone.
MRS of the Heart
Hall B Tuesday 13:30-15:30
1316. MRI/MRS Biomarkers for Response Evaluation in Patients with CABG
Zhuoli Zhang 1 , Shengyong Wu 2 , Ying Liu 3 , Savita Puri 4 , Shara Ramaswamy 5 , Yi Huan 3 , Debiao Li 1
1 Northwestern University, Chicago, IL, United States; 2 Tianjin Medical University; 3 Fourth Military Medical University; 4 University
of Rochester Medical Center; 5 Florida International University
Phosphorus-31 magnetic resonance spectroscopy (31P-MRS) represents a unique instrument to noninvasively monitor myocardial metabolism in humans.
The technique has been used to study the metabolism in myocardium in patients with coronary artery disease (CAD). The measurements permit quantitative
estimation of the phosphocreatine (PCr)/adenosine triphosphate (â-ATP) ratio which reflects the energetic state of the myocardium. Previous studies
investigated the effect of successful coronary artery bypass grafting surgery (CABG) upon left ventricular function. Although residual myocardial viability
in patients with CAD and extensive regional asynergy is associated with improved ventricular function after CABG, the relationship between myocardial
metabolism and heart function after CABG remains unclear. We hypothesized that cardiac function benefits from high-energy phosphate (HEP) and sought
to investigate the relationship between HEP and cardiac function in CAD patients using cine magnetic resonance imaging (cine-MRI) and 31P-MRS.
1317. Cardiac Lipid Content as Determined by Magnetic Resonance Spectroscopy Increases After Exercise
Protocol in the Fasted State
Vera Schrauwen-Hinderling 1 , Lena Bilet 1 , Tineke van de Weijer 1 , Matthijs Hesselink 1 , Jan Glatz 1 , Joachim
Wildberger 1 , Michael Schär 2,3 , Eline Kooi 1 , Patrick Schrauwen 1
1 Maastricht University Medical Center, Maastricht, Netherlands; 2 Johns Hopkins University, Baltimore, United States; 3 Philips Health
Care, Cleveland, United States
Excessive lipid accumulation in the myocardium may predispose to cardiomyopathy. Elevated plasma (free) fatty acids (FA) might be a risk factor herein.
Cardiac lipid content was determined by 1H-MRS in healthy men (fasted state). Subsequently, subjects cycled for two hours and rested for three hours, after
which cardiac lipid content was measured again. All subjects performed this protocol twice: once fasted and once while ingesting glucose to keep FA low.
Cardiac lipid content was elevated after the fasted test day but unchanged when glucose ingestion kept FA low. This suggests that FA are important in
determining cardiac lipid content.
1318. The Role of Cardiac Carbonic Anhydrases in Vivo: A Hyperpolarised 13 C MR Study
Marie Allen Schroeder 1 , Pawel Swietach 1 , Philip Lee 2 , Ferdia A. Gallagher 3,4 , Ben Rowlands 1 , Claudiu T.
Supuran 5 , Kevin M. Brindle, 4,6 , Richard D. Vaughan-Jones 1 , George K. Radda 1,2 , Kieran Clarke 1 , Damian
J. Tyler 1
1 Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom; 2 Biomedical Sciences Institute,
Singapore Bioimaging Consortium, Singapore, Singapore; 3 Radiology, Addenbrooke's Hospital, University of Cambridge, Cambridge,
United Kingdom; 4 Li Ka Shing Centre, CRUK Cambridge Research Institute, Cambridge, United Kingdom; 5 Dipartimento di
Chimica, University of Florence, Florence, Italy; 6 Biochemistry, University of Cambridge, Cambridge, United Kingdom
Carbonic anhydrase (CA) catalyses the hydration of CO 2 to form HCO 3 - and H+, an inter-conversion which serves as a major pH buffer in blood plasma and
inside cells. To date, cardiac isoforms of CA have only been studied in vitro, where their function could be drastically different than in vivo. The aim of this
study was to determine the effects of intra- and extracellular isoforms of CA on CO 2 efflux from the heart, in vivo, based on MRS detection of 13 CO 2
generated from the metabolism of hyperpolarised [1- 13 C]pyruvate. Our results indicated that extracellular CAs do not affect cardiac CO 3 removal under
control perfusion conditions, though may have a role in ischemia. Further, we observed that intracellular CA activity trapped HCO 3 - and H+ within the
myocyte, which could potentially acidify the intracellular space. Physiological levels of cardiac intracellular CA must balance retention of myocardial
bicarbonate to buffer potential acid/base disturbances, without causing excessive intracellular acidification.
1319. Evaluation for Optimal Stress System for Cardiac MR Study
Hee-Won Kim 1,2 , Karam Souibri 3 , Gerald M. Pohost 1,4
1 Radiology, University of Southern California, Los Angeles, CA, United States; 2 Cardiology, Heart and Vascular Institute, Hollywood
Presbyterian Hospital, Los Angeles, CA, United States; 3 Cardiology, University of Southern California, Los Angeles, CA, United
States; 4 Electrical Engineering, University of Southern California, Los Angeles, CA, United States
A stress control system was developed and evaluated to obtain improved precision of the stress MR studies. The stability in stress was achieved by the feedforward
or feedback control and audio-visual stimulation actuated by the error signal. The system performance was evaluated by cardiac P-31 MRS at 3T.