TRADITIONAL POSTER - ismrm

Poster Sessions
2090. Absolute Quantification of Myelin Related Volume in the Brain
J. B.M. Warntjes 1 , J. West 1,2 , A. M. Landtblom 1,3 , P. Lundberg 2
1 Center for Medical Imaging Science and Visualization (CMIV), Linköping, Sweden; 2 Department of Medicine and Health, Division
of radiation physics, Linköping, Sweden; 3 Department of Clinical Neuroscience, Linköping, Sweden
A method is described to measure the myelin related volume fraction for each voxel for a complete brain within a scan time of 5 to 6 minutes, based on
absolute quantification of the relaxation rates R1 and R2 and proton density. The absolute decrease of visible PD with a simultaneous increase of R1 and R2
corresponds to an increase of myelin. Myelin related volume is correlated with Fractional Anisotropy maps and conventional T1W, T2W and FLAIR
images. Repeated measurements show a standard deviation of 1-2% in myelin volume for the whole brain.
2091. Changes in Multiple Sclerosis Over 6 Months as Seen with T2 Relaxation and Diffusion Histograms
Irene Margaret Vavasour 1 , Shannon Heather Kolind 2 , Cornelia Laule 1 , Burkhard Maedler 3 , David K.B.
Li 1 , Anthony L. Traboulsee 4 , Alex L. MacKay 1,3
1 Radiology, University of British Columbia, Vancouver, BC, Canada; 2 FMRIB Centre, University of Oxford, Oxford, United
Kingdom; 3 Physics and Astronomy, University of British Columbia; 4 Medicine, Univeristy of British Columbia
Twelve multiple sclerosis subjects and 12 healthy age and gender matched controls were scanned twice at a 6 month interval to compare histograms derived
from normal white matter (NWM), normal appearing white matter (NAWM) and multiple sclerosis lesions. Myelin water fraction (MWF), geometric mean
T 2 (GMT 2 ), fractional anisotropy, mean diffusivity and the eigenvalues were measured. Mean MWF and GMT 2 histograms did not differ between the two
time points although histograms from NWM, NAWM and lesions were different. Histograms from the diffusion metrics differed slightly between month 0
and 6. T 2 relaxation and diffusion metrics give complementary information about MS tissue.
2092. Myelin Water Fraction Reduction in Multiple Sclerosis Normal Appearing White Matter: Where Are
All the Zeroes?
Cornelia Laule 1,2 , Shannon H. Kolind 3 , Irene M. Vavasour 1 , Burkhard Mädler 2 , Joel Oger 4 , Anthony L.
Traboulsee 4 , Wayne Moore 5 , David KB Li 1 , Alex L. MacKay 1
1 Radiology, University of British Columbia, Vancouver, BC, Canada; 2 Physics & Astronomy, University of British Columbia,
Vancouver, BC, Canada; 3 FMRIB Centre, University of Oxford, Oxford, United Kingdom; 4 Medicine, University of British
Columbia, Vancouver, BC, Canada; 5 Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
Using T 2 relaxation it is possible to measure myelin water fraction in multiple sclerosis (MS) normal appearing white matter (NAWM). Previous work
employing a region of interest based approach found reduced myelin water fraction (MWF) in MS NAWM relative to normal white matter in controls. Using
an improved 3D T2 relaxation sequence at higher field strength, we also found reduced MWF in MS NAWM which correlated with EDSS. Voxels with
lowest MWF values were not uniformly distributed throughout the NAWM, but rather tended to arise near grey/white matter interfaces in the periphery of
the brain.
2093. Individual Voxel Based Analysis of Brain Magnetization Transfer Maps Evidences High Variability of
Grey Matter Injury in Patients at the First Stage of Multiple Sclerosis
Lorena Jure 1 , Wafaa Zaaraoui 1 , Celia Rousseau 1 , Françoise Reuter 1 , Audrey Rico 1 , Irina Malikova 1 ,
Sylviane Confort-Gouny 1 , Patrick J. Cozzone 1 , Jean Pelletier 1 , Bertrand Audoin 1 , Jean-Philippe Ranjeva 1
1 CRMBM UMR CNRS 6612, Marseille, France
Various MR studies, based on group comparison have demonstrated a common pattern of grey matter (GM) injury in patients since the early stage of
multiple sclerosis (MS). However, little is know about the potential variability of this early GM involvement which may determine the high variability of the
functional prognosis. We propose an optimized method to obtain from statistical mapping analyses applied on MTR data, the GM MTR abnormalities of
subjects at the individual level. Feasibility is demonstrated in early MS patients showing variable individual patterns of GM injury that could explain
heterogeneity of clinical progression for this disease.
2094. Definition of Regional Distribution of Gray Matter Loss in MS Patients with Fatigue: A Voxel-Based
Morphometry Study
Maria A. Rocca 1 , Gianna Riccitelli 1 , Cristina Forn 1 , Bruno Colombo 2 , Giancarlo Comi 2 , Massimo Filippi 1
1 Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University
Hospital San Raffaele, Milan, Italy; 2 Department of Neurology, Scientific Institute and University Hospital San Raffaele, Milan, Italy
Using voxel-based morphometry, we defined the topographical distribution of gray matter (GM) atrophy in multiple sclerosis (MS) patients with fatigue.
Compared to healthy volunteers and to MS patients without fatigue, patients with fatigue had reduced GM volume in several areas of the left frontal lobe,
including the middle frontal gyrus (MFG), the precentral gyrus, the superior and inferior frontal gyrus, and the cingulate gyrus. Fatigue severity was
significantly correlated with atrophy of the precentral gyrus, suggesting that structural damage in areas that are part of the sensorimotor network might be
among the mechanisms responsible for the presence of MS-related fatigue.