TRADITIONAL POSTER - ismrm

Poster Sessions
2449. Diffusion Tensor Imaging of the Pediatric Optic Nerve: Intrinsic and Extrinsic Pathology Compared to
Normal Controls
Joshua Paul Nickerson 1 , Michael B. Salmela 2 , Chris John Koski 3 , Trevor Andrews 2 , Christopher G.
Filippi 4
1 Radiology, Fletcher Allen Healthcare/The University of Vermont, Burlington, VT, United States; 2 School of Medicine, University of
Vermont, Burlington, VT, United States; 3 Political Science, James Madison University, Harrisonburg, VA, United States;
4 Neuroradiology, Fletcher Allen Healthcare/The University of Vermont, Burlington, VT, United States
MRDTI normative data from the optic nerves in 70 normal children was compared to diffusion parameters in children with lesions both intrinsic and
extrinsic to the visual pathway. Significant decrease in FA and increase in ADC was present in intrinsic lesions, while extrinsic lesions where only mass
effect on the nerves was present did not affect diffusivity or anisotropy. This may improve presurgical planning for visual pathway lesions.
2450. Spinal Cord White Matter Integrity in Patients with Cervical Spondylosis Is Related to Severity of
Spinal Canal Stenosis: A Combined MRI and Diffusion Tensor Imaging Study
Antoine Feydy 1 , Pavel Lindberg 1 , Francois Rannou 2 , Jean-Luc Drape 1 , Marc A. Maier 3
1 Radiology B, Hopital Cochin, Paris, France; 2 Rehabilitation, Hopital Cochin, Paris, France; 3 LNRS, Universite Paris Descartes, Paris,
France
We used DTI to test if the severity of spinal canal stenosis is related to the degree of spinal white matter integrity in patients with cervical spondylosis.
Patients and controls were studied with DTI of cervical spinal cord. The patients had lower FA than controls and increased spinal canal stenosis. The mean
degree of spinal canal stenosis correlated with mean FA, i.e., patients with least cervical canal space had lowest FA values of the whole cervical spinal cord.
The results show that DTI can quantify spinal cord white matter degeneration related to spinal canal stenosis in patients with cervical spondylosis.
Advanced Imaging of Spine & Spinal Cord
Hall B Monday 14:00-16:00
2451. Diffusion Tensor Imaging of the Normal and Injured Pediatric Spinal Cord at 1.5 T
Feroze B. Mohamed 1 , Louis N. Hunter 2 , Nadia Barakat 1 , Chia-Shang Liu 1 , Haris Sair 3 , Amer Samdani 2 ,
Randal Betz 2 , Scott H. Faro 1 , John Gaughan 1 , Mary J. Mulcahey 2
1 Temple University, Philadelphia, PA, United States; 2 Shriners Hospital for Children; 3 Massachusetts General Hospital
To measure and establish normative DTI parameters of healthy spinal cord tissue in children with idiopathic scoliosis as a means for comparison with
children with spinal cord injury (SCI). 5 subjects with idiopathic scoliosis and 5 subjects with SCI were imaged twice using DTI. The SCI subjects showed
reduced FA values and increased D values compared with control subjects. Test-retest reproducibility showed excellent inter class correlation (ICC) in all
the control group DTI index values (>0.9) while the SCI group showed moderate ICC (>0.7). There were statistically significant correlations between the
DTI indices and several ISNCSCI clinical impairment scores.
2452. Reduced Field of View Imaging for Twice-Refocused Diffusion EPI Using a Perpendicular Refocusing
Slab
Rafael Luis O'Halloran 1 , Samantha J. Holdsworth 1 , Stefan Skare 1 , Roland Bammer 1
1 Department of Radiology, Stanford University, Stanford, CA, United States
A simple method for reducing the phase field of view in twice-refocused DTI EPI is presented and compared with full of view imaging in DTI of the upper
spine. The 180-degree refocusing slice select pulses are played out on the phase encoding axis instead of the slice-encoding axis. This allows the phase field
of view to be reduced to the width of the perpendicular refocusing slab without introducing wrap. Results show that the reduced field of view method
produces diffusion weighted images of the cervical and thoracic spine that are less distorted than those of standard full field of view EPI for the same scan
time.
2453. Spinal Cord Diffusion Tensor Imaging (DTI) and 1H-MR Spectroscopy (MRS) at 1.5T and 3T.
Virginie Callot 1 , Yann Le Fur 1 , Jean-Philippe Ranjeva 1 , Guillaume Duhamel 1 , Patrick J. Cozzone 1
1 Centre de Résonance Magnétique Biologique et Médicale (CRMBM), CNRS, UMR 6612, Faculté de Médecine, Marseille, France
Diffusion Tensor Imaging (DTI) and single-voxel 1H-MR spectroscopy (MRS) of the spinal cord (SC) are challenged by several difficulties, including
strong magnetic field inhomogeneities, respiratory and cardiac movements, and small size of the spinal cord. Whereas several studies have shown promising
results, there is scant literature comparing 1.5T and 3T MRI and MRS. In this abstract, we investigate the efficiency of the available manufacturer MRS and
DTI sequences, in terms of image/spectra quality and metrics, at both 1.5T and 3T, for different spinal cord locations (thoracic and cervical levels) and for
different imaging plane orientations (sagittal and axial).
2454. Diffusion Tensor MR Imaging of the Healthy Human Cervical, Thoracic and Lumbar Spinal Cord
Rachael Lee Bosma 1 , Christopher Alan Kidd 1 , Patrick W. Stroman 1,2
1 Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada; 2 Departments of Diagnostic Radiology and Physics,
Queen's University, Kingston, Ontario, Canada
A greater understanding of diffusion indices within the healthy spinal cord is necessary for comparison with clinical populations. Here we measured
fractional anisotropy and apparent diffusion coefficient values for cervical (C2-C7), thoracic (T3-T8) and lumbar (T10-L1) regions of the cord. FA vs. ADC
values were plotted and three clusters were determined using a k-means partition to characterize each region of the spinal cord. DTI indices in the healthy
cord were observed to be relatively consistent across regions, indicating that changes in these indices as a result of trauma at any level can be characterized
relative to these observed indices.