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was found. However, adults with schizophrenia did not demonstrate such asymmetry. Lack of leftward asymmetry in schizophrenia may imply a disruption
in the normal pattern of structural and functional connectivity in frontal-temporal brain regions.
2141. White Matter Abnormalities Associated with Neurological Soft Signs in First-Episode Schizophrenia:
A Diffusion Tensor Imaging Study.
Christine Rodriguez-Régent 1 , Sabine Mouchet-Mages 2 , Sebastian Rodrigo, Marie-Odile Krebs 2 , Catherine
Oppenheim, Jean-François Meder
1 Department of Morphologic and Functional Imaging, University Paris Descartes, Sainte Anne Hospital, PARIS, France;
2 Pathophysiology of Psychiatric Diseases, University Paris Descartes, Sainte Anne Hospital, PARIS, France
Schizophrenic patients often present with neurological soft signs (NSS) but the cerebral changes underlying these signs are poorly understood. This study
examines the microstructural changes associated with NSS using Diffusion Tensor Imaging. Forty-five patients with first-episode schizophrenia underwent
DTI and a neurological examination. Fractional anisotropy (FA), calculated using a voxel based analysis, was analyzed with NSS scores. FA was negatively
correlated with NSS scores in the white matter of the right prefrontal, left occipital and right parietal areas. Thus, this is the first study which confirms that
microstructural changes of white matter are associated with NSS in schizophrenia.
2142. Interaction of Hippocampal Volume and N-Acetylaspartate Concentration Deficits in Schizophrenia: A
Combined MRI and 1H-MRS Study at 3 T
Florian Schubert 1 , Andreas Klaer 2 , Martina Ballmaier 2 , Karolina Leopold 2 , Ines Haeke 2 , Martin Schaefer 3 ,
Ruediger Bruehl 1 , Juergen Gallinat 2
1 Physikalisch-Technische Bundesanstalt, Berlin, Germany; 2 Charite University Medicine, Berlin, Germany; 3 Kliniken Essen, Essen,
Germany
We used single voxel 1H-MRS at 3 Tesla to measure absolute NAA concentrations and, as a gold standard of CNS volumetry, a validated delineation
protocol for the hippocampus to study the interaction between between hippocampal NAA reduction and volume deficits in 29 schizophrenic patients and 44
controls. The hippocampus of the patients exhibited a significantly smaller volume and lower NAA concentration than that of healthy controls. For
schizophrenic patients a significant negative correlation between hippocampal NAA concentration and volume was observed. The results argue for a
coexistent neurochemical and structural deficit in the hippocampus of schizophrenic patients.
2143. An MRI Study of the Caudate Nucleus in Euthymic Bipolar I Disorder
Louise Emsell 1 , Camilla Langan 1 , Sarah Hehir 1 , Helen Casey 1 , Wil van der Putten 1 , Peter McCarthy 1 ,
Rachel Skinner 1 , Dara M. Cannon 1 , Colm McDonald 1
1 NUI Galway, Galway, Ireland
Bipolar disorder is a complex illness characterised by extremes of mood. It is likely that subtle changes in neuroanatomy contribute to the underlying
aetiopathology of the disorder. This study sought to identify differences in the volume of the caudate nucleus in a prospectively confirmed sample of 59
remitted patients compared to 59 individually age and gender matched healthy controls to identify trait related anatomical changes. We did not find a main
of effect of diagnosis. However,we did detect gender differences in caudate volume (F>M),age-related volumetric decrease across the study population and a
main effect of family history in patients.
2144. Brain Matter Corrected Quantification of Phosphomono- And Phosphodiesters in the Brain of
Patients with Schizophrenia
Wolfgang Weber-Fahr 1 , Mathias Zink 2 , Andreas Meyer-Lindenberg 2 , Monika Uhrig 1 , Nuran Tunc-Skarka 1 ,
Mareen Hoerst 1 , Helga Welzel-marquez 1 , Alexander Sartorius 2 , Gabriele Ende 1
1 Neuroimaging, Central Institute of Mental Health, Mannheim, NA, Germany; 2 Dept. Psychiatry, Central Institute of Mental Health,
Mannheim, NA, Germany
A 3D-whole head RINEPT sequence was used together with point-spread function corrected tissue segmentation for robust absolute quantification of
spectral edited Phosphomono- and –diester-signals in the brains of schizophrenic patients and controls. The corrected metabolite concentrations show a
significant reduction of Phosphocholine and Glycerophosphocholine (GPC) in the basal ganglia and thalamus of schizophrenic patients compared to
controls. GPC was also significantly lower in the cerebellum while Phosphorylethanolamine showed a trend for lower concentration in patients in the frontal
region.
2145. Altered Fiber Radial Diffusivity in Schizophrenia Revealed by HARDI
Xin Hong 1,2 , Lori R. Arlinghaus 3 , Herbert Y. Meltzer 4 , Sohee Park 5 , Adam W. Anderson, 2,3
1 Institute of Imaging Science, Vanderbilt University , Nashville, TN, United States; 2 Department of Biomedical Engineering,
Vanderbilt University, Nashville, TN, United States; 3 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United
States; 4 Department of Psychiatry, Vanderbilt University, Nashville, TN, United States; 5 Department of Psychology, Vanderbilt
University, Nashville, TN, United States
We performed a group comparison of the diffusion properties and intravoxel fiber coherence estimated by FORECAST analysis. Significantly higher FA is
found in schizophrenia patients compared to healthy controls in the left superior longitudinal fasciculus and bilateral internal capsules. In all three regions,
strong negative correlation between FA and radial diffusivity is found at both voxel and cluster levels, even after controlling for coherence variation.
Significantly lower coherence is found between the two groups at the cluster level, but not voxel level. Our results suggest the altered FA was mainly due to
structural rather than organizational changes in these regions.