TRADITIONAL POSTER - ismrm

Poster Sessions
1958. Resting-State FMRI Contributes to Differentiate Patients with Dementia with Lewy Bodies from Those
with Alzheimer's Disease
Barbara Basile 1 , Mara Cercignani 1 , Laura Serra 2 , Roberta Perri 3 , Camillo Marra 4 , Lucia Fadda 3 , Carlo
Caltagirone 3,5 , Marco Bozzali 2
1 Neuroimaging Laboratory, Santa Lucia Foundation, Rome , Italy, Italy; 2 Neuroimaging Laboratory, Santa Lucia Foundation, Rome,
Italy, Italy; 3 Clinical and Behavioural Neurology Laboratory, Santa Lucia Foundation, Rome, Italy, Italy; 4 Department of
Neurosciences, Catholic University of Rome, Roma, Italy, Italy; 5 Department of Neurosciences , University of Torvergata, Rome,
Italy, Italy
Resting-state fMRI was used to investigate changes of functional connectivity (FC) within specific resting-state networks (RSNs) in the presence of
Alzheimer's disease (AD) and dementia with Lewy Bodies (DLB) as compared to normal aging. Using ICA analysis, we identified 10 RSNs across subjects.
AD patients revealed reduced FC in the posterior cingulate, within the default-mode-network. Conversely, DLB patients showed reduced FC in occipital
areas, within the visual network. These findings respectively account for brain disconnection between medial temporal lobes and other association cortexes
in the development of AD symptoms, and for occipital abnormalities potentially responsible for visual hallucinations in DLB.
1959. On Using Optimized MRS Acquisitions for Improved Mild Cognitive Impairment Diagnosis
Ileana Hancu 1 , John Cowan 2 , Earl Zimmerman 2
1 GE Global Research Center, Niskayuna, NY, United States; 2 Albany Medical Center, Albany, NY, United States
Accurate and repeatable mI measurements may offer a simple means for diagnosing or monitoring treatment in mild cognitive impairment (MCI) patients.
Unfortunately, such repeatable measurements are difficult to obtain in vivo. The current report investigates the capability of CPRESS to better separate MCI
subjects from normal controls (NC’s). With only 12 subjects in each of the MCI and NC categories, p-values separating the two classes decrease from 0.03
to 0.002 when using CPRESS instead of a short TE PRESS sequence. The impact of more repeatable mI concentration measurements in diagnosing or
monitoring MCI evolution or treatment is discussed.
1960. Classification of AD, MCI and Controls Using Large-Scale Network Analysis
Gang Chen 1 , Barney Douglas Ward 1 , Chunming Xie 1 , Zhilin Wu 1 , Wenjun Li 1 , Jennifer Jones 2 , Malgorzata
Franczak 2 , Piero Antuono 2 , Shi-Jiang Li 1
1 Department of Biophysics,, Medical College of Wisconsin, Milwaukee, WI, United States; 2 Department of Neurology, Medical
College of Wisconsin, Milwaukee, WI, United States
There has been great interest in developing objective biologically based markers that can be used to predict risk, diagnose, stage, or track the course and
treatment of dementia and other neurodegenerative diseases. Alzheimer disease (AD) is the most common form of dementia. Mild cognitive impairment
(MCI) is a transitional state between normal aging and dementia, and is often considered a risk factor for AD. In this study, we employed resting-state MRI
connectivity methods and the large-scale network analyses to discriminate between AD, MCI and healthy control subjects.
1961. Investigating Parkinson’s Disease Using Rotating Frame MRI
Silvia Mangia 1 , Timo Liimatainen 2 , Igor Nestrasil 3 , Michael Garwood 1 , Paul Tuite 3 , Dennis Sorce 1 , Shalom
Michaeli 1
1 CMRR - Dept. of Radiology, University of Minnesota, Minneapolis, MN, United States; 2 Department of Biotechnology and
Molecular Medicine, A.I. Virtanen Institute for molecular Medicine, University of Kuopio, Kuopio, Finland; 3 Dept. of Neurology,
University of Minnesota, Minneapolis, MN, United States
Rotating frame relaxation (T1rho and T2rho) were measured under a variety of RF pulses (namely continuous-wave, and frequency swept pulses in the
adiabatic and subadiabatic regime) on twenty one Parkinson's disease (PD) subjects at 4T. Results demonstrate that different RF pulses significantly
modulate the rotating frame relaxations in the substantia nigra (SN), providing the opportunity to extract fundamental parameters of the system based on
theoretical modeling of the relaxation channels. The greatest sensitivity to identify sub-regions of the SN was achieved by the so-called RAFF pulse, which
combines T1rho and T2rho relaxation mechanisms. Measurements from ferritin samples were additionally performed.
1962. Parkinson¡¯s Disease and Imaging of the Substantia Nigra Structure with 7.0T MRI
Dae-Hyuk Kwon 1 , Hye-Jin Jeong 1 , Se-Hong Oh 1 , Jong-Min Kim 2 , Syung-Yeon Park 1 , Young-Bo Kim 1 ,
Beom-Seok Jeon 2 , Zang-Hee Cho 1
1 Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon, Korea, Republic of; 2 Movement Disorder
Center, Seoul National University Hospital, Seoul, Korea, Republic of
T2* weighted MR image is influenced by iron deposition, so that SN shows up iron-related MRI contrast for all that SN is gray matter. Therefore T2* MR
imaging shows great potential in PD study using ultra high field (UHF) 7.0T. And 3D T2* Gradient Echo (GE) sequence makes it possible to study a
volumetric analysis and a structural morphometry for SN. This method is validated, despite the reduced SNR associated with fast imaging techniques. And
3D model of the SN shows quite well structural changes in PD case.
1963. Perfusion Networks in Parkinson’s Disease Revealed Using Arterial Spin Labeling
Tracy R. Melzer 1,2 , Richard Watts, 1,3 , Michael R. MacAskill 1,2 , Ross Keenan 4 , Ajit Shankaranarayanan 5 ,
David C. Alsop 6 , Charlotte Graham 1,2 , Leslie Livingston 1 , John C. Dalrymple-Alford, 1,7 , Tim J. Anderson 1,2
1 Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand; 2 Medicine, University of Otago,
Christchurch, New Zealand; 3 Physics and Astronomy, University of Canterbury, Christchurch, New Zealand; 4 Christchurch Radiology
Group, Christchurch, New Zealand; 5 GE Healthcare, Menlo Park, CA, United States; 6 Beth Israel Deaconess Medical Center, Boston,
MA, United States; 7 Pyschology, University of Canterbury, Christchurch, New Zealand
Pseudo-continuous ASL was used to investigate cerebral blood flow in 44 Parkinson’s disease (PD) patients and 26 controls. Principal component analysis
produced a set of covariance patterns which were used to form a perfusion network that successfully distinguished PD from control. The PD-related network