TRADITIONAL POSTER - ismrm

Poster Sessions
2182. The Effect of Fiber Affinity on Predicted Cancer Cell Migration Based on MR-DTI
Anitha Priya Krishnan 1 , Delphine Davis 2,3 , Paul Okunieff 3 , Walter G. O'Dell, 1,3
1 Biomedical Engineering, University of Rochester, Rochester, NY, United States; 2 Imaging Sciences, University of Rochester,
Rochester, NY, United States; 3 Radiation Oncology, University of Rochester, Rochester, NY, United States
The current methods for determining the treatment margin for Stereotactic Radiotherapy of gliomas are inadequate as recurrences often occur at the
boundary of the treatment margin. We developed a random walk model to determine the microscopic spread of tumor cells to facilitate in the development of
anisotropic treatment margins. In this study we have shown that the affinity of cancer cells to fibers in the brain can be modeled better by the spread in the
direction of migration about the Principal Diffusion Direction determined using DTI than by using a variable step-size in the random walk of cancer cells.
2183. Correlating DTI-Based Cancer Cell Migration Model Predictions with the Location of Secondary
Tumors
Anitha Priya Krishnan 1 , Delphine Davis 2 , Paul Okunieff 3 , Walter G. O'Dell 3
1 Biomedical Engineering, University of Rochester, Rochester, NY, United States; 2 Imaging Sciences, University of Rochester,
Rochester, NY, United States; 3 Radiation Oncology, University of Rochester, Rochester, NY, United States
The current methods for determining the treatment margins for stereotactic radiotherapy of gliomas is inadequate as the tumor often recurs at the boundary
of the treatment margin. The areas of high normalized cell migration predicted by our random walk model coincide with the direction along which the tumor
recurs. Here we have established that there is a statistically significant correlation between the model predictions and the recurrence site and the average
normalized cell concentration in the recurrence site is higher than the normalized cell concentration in 78% of the voxels on a surface equidistant from the
primary tumor surface.
2184. Decreased Cerebral Oxygen Extraction Fraction (OEF) Measured by MR QBOLD Following
Stereotactic Radiosurgery (SRS) in Patients with Metastatic Brain Tumors
Parinaz Massoumazdeh 1 , Xiang He 1 , Sarah Jost 2 , Keith Rich 3 , Dmitriy Yablonskiy 1 , Tammie Benzinger 4
1 Mallinckrodt Institute of Radiology, Washington University in Saint Louis; 2 Swedish Hospital, Seattle, WA, United States;
3 Neurosurgery, Washington University in Saint Louis; 4 Mallinckrodt Institute of Radiology, Washington University in Saint Louis, St.
Louis, MO, United States
There is growing evidence that solid organ tumors with ability to grow in hypoxic conditions demonstrate resistance to conventional chemotherapy and
radiation therapy. Here, we used MR qBOLD technique to measure the OEF of metastatic brain tumors before and after SRS. In this population, OEF of
both the tumors and peritumoral edema prior to SRS was elevated. Following SRS, OEF decreased in the areas of lesions. This suggests that qBOLD OEF
may provide a new method to monitor brain tumor response to therapy.
2185. A Comparison of Signal Intensity & DCE-MRI Based Methods for Assessing Enhancing Fraction
Samantha Jane Mills 1,2 , Gerard Thompson 1 , Giovanni Buonacorrsi 1 , Geoff James Parker 1 , Alan Jackson 1,2
1 Imaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom; 2 Department of
Neuroradiology, Salford Royal Foundation Trust Hospital, Salford, Greater Manchester, United Kingdom
The established technique for measuring Enhancing Fraction utilises the initial area under the concentration curve derived from a DCE-MRI acquisition.
This can be time consuming and requires complex post processing analysis. This study examines the feasibility of obtaining an measure of Enhancing
Fraction from conventional, pre and post contrast T1weighted imaging and compares this to the established DCE-MRI derived technique. The two methods
show good correlation but are not directly interchangeable methods of measuring Enhancing Fraction.
2186. Simultaneous Resting State FMRI and FET-PET
Irene Neuner 1,2 , Joachim Bernhard Maria Kaffanke 1 , Cornelius Werner 1,2 , Martina Reske 1,3 , Karl-Joseph
Langen 1 , Hans Herzog 1 , N. Jon Shah 1,2
1 Institute of Neurosciences and Medicine 4, Medical Imaging Physics, Forschungszentrum Jülich GmbH, 52425 Juelich, Germany;
2 Faculty of Medicine, Department of Neurology, RWTH Aachen University, 52074 Aachen, Germany; 3 Department of Psychiatry,
University of California San Diego, San Diego, CA, United States
For the planning of surgical intervention in human brain tumour cases, it is important to know if critical brain areas might be affected by the surgical process
itself. PET imaging using radiolabelled amino acids is a valuable technique for the diagnosis of cerebral gliomas. O-(2-[18F]Fluorethyl)-L-Tyrosin (FET) is
a well established amino acid tracer that delivers information about tumour extent, the optimal biopsy site and detection of tumour recurrences. In this study,
FET-PET and BOLD-fMRI data were acquired simultaneously; data from a representative human brain tumour case are presented. In contrast to task-based
functional studies, resting state fMRI offers the opportunity to detect a variety of cortical networks in a single experiment.
2187. Multi-Layer Appearance of Abscess Capsule on Post-Gd SWI Images: Effects of Filtering and Phase
Mask
Ping-Hong Lai 1,2 , Hing-Chiu Chang 3,4 , Hsiao-Wen Chung 4
1 Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; 2 School of Medicine, National Yang-Ming
University, Taipei, Taiwan; 3 Applied Science Laboratory, GE Healthcare Taiwan, Taipei, Taiwan; 4 Institute of Biomedical Electronics
and Bioinformatics, National Taiwan University, Taipei, Taiwan
SWI is a novel MR technique that exploits the magnetic susceptibility differences of various tissues, such as venous structure and iron deposition. When
SWI was applied to patients with abscess, we found that, compared with homogeneous rim-enhancement on post-contrast magnitude images, the capsular
portion of pyogenic brain abscess on post-contrast SWI images showed a multi-layer appearance. In this work, in order to clarify whether this multi-layer
characteristic is physiological or technical in it origin, we investigate the causes of this multi-layer appearance, and use a theoretical model to simulate the
multi-layer appearance upon the use of different SWI processing parameters.