TRADITIONAL POSTER - ismrm

Poster Sessions
2472. Evaluation of Neoadjuvant Chemotherapy Response of Breast Cancer at 3.0T
Jeon-Hor Chen 1,2 , s Bahri 1 , P Carpenter 3 , H-J Yu 1 , R Mehta 4 , O Nalcioglu 1 , M-Y Lydia Su 1
1 Center for Functional Onco-Imaging, UC Irvine, Irvine, CA, United States; 2 China Medical University Hospital, Taichung, Taiwan;
3 Department of Pathology, UC Irvine, Irvine, CA, United States; 4 Department of Medicine, UC Irvine, Irvine, CA, United States
The results analyzed from 3.0 T were consistent with our previous findings using 1.5T with a lower spatial resolution, suggesting that the limitation of MRI
in diagnosis of post-NAC cancer cannot be improved with a higher SNR or a higher spatial resolution. Our current protocol at 3.0 T still could not detect
residual tumor presenting as scattered cells or small foci, which often occurs in non-mass-like lesions. These types of invasive cancer cells do not need
angiogenesis to survive, and if so, they will not show contrast enhancements.
2473. Reduction of Breast Density Following Tamoxifen Treatment Evaluated by 3-D MRI
Jeon-Hor Chen 1,2 , Yeun-Chung Chang 3 , Daniel Chang 1 , Yi-Ting Wang 3 , Ke Nie 1 , Ruey-Feng Chang 3 ,
orhang Nalcioglu 1 , Chiun-Sheng Huang 3 , M-Y Lydia Su 1
1 Center for Functional Onco-Imaging, UC Irvine, Irvine, CA, United States; 2 China Medical University Hospital, Taiwan; 3 National
Taiwan University, Taiwan
We have demonstrated that the breast density analyzed based on a 3D MR method can be used to investigate the changes associated with tamoxifen
treatment. We found a significant reduction in fibroglandular tissue volume and percent breast density after treatment, and the density reduction was
positively correlated with the baseline density and treatment duration.
2474. MRI Evaluation of Decrease of Breast Density in the Contralateral Normal Breast of Patients
Receiving Neoadjuvant Chemotherapy
Jeon-Hor Chen 1,2 , Ke Nie 1 , S Bahri 1 , Rita S. Mehta 3 , Chieh-Chih Hsu 2 , Fei-Ting Hsu 2 , Han-Ni Shih 2 ,
Muqing Lin 1 , orhang Nalcioglu 1 , M-Y Lydia Su 1
1 Center for Functional Onco-Imaging, UC Irvine, Irvine, CA, United States; 2 China Medical University Hospital, Taichung, Taiwan;
3 Department of Medicine, UC Irvine, Irvine, CA, United States
We have demonstrated the feasibility of investigating the reduction of density following chemotherapy using a quantitative analysis method based on MRI.
Patients receiving chemotherapy showed reduction of breast density, and that the effects were more pronounced in younger women than older (postmenopausal)
women. The results suggest that the reduction of breast density after chemotherapy was possibly mediated through impaired ovarian function.
The reduction could be clearly noted after 1 to 2 cycles of AC regimen. Although the density continued to decrease after 4 cycles of AC and the following
Taxane regimen, the subsequent effect was smaller.
2475. Pushing Old Boundaries in Breast MRI: Non-Fatsaturated Dynamic Imaging at Very Short TE
Christian Geppert 1 , Rolf Janka 2 , Berthold Kiefer 1 , Michael Uder 2 , Evelyn Wenkel 2
1 MR Oncology, Siemens Heatlthcare, Erlangen, Germany; 2 Radiologisches Institut, Universitätsklinikum Erlangen, Erlangen,
Germany
In non-fatsuppressed dynamic breast imaging, it is a well accepted recommendation to acquire data at or close to echo times that fulfil the in-phase condition
for fat and water, such as 4.7ms at 1.5T, in order to avoid partial volume effects that lead to signal cancellation at fat/water interfaces. Thus it is usually
suggested of using either in-phase TE or “TE less than 1.2ms” resulting in a phase difference of below 90°. In a comparable parameter setting this would
result in a decrease of 50% of the total acquisition time. With current gradient systems and fast imaging sequences this has now become possible without
compromising the matrix size or the bandwidth. In this work we have set up an interleaved protocol approach to achieve a direct comparison of a minimum
TE acquisition with a clinical standard protocol.
2476. Improved Diagnostic Accuracy in DCE MR-Mammography by Normalization of Kinetic Parameters
Following AIF Deconvolution
Endre Grøvik 1 , Kjell-Inge Gjesdal 2 , Kathinka Kurz Dæhli 3 , Atle Bjørnerud 4
1 University of Oslo, Oslo, Norway; 2 Sunnmøre MR-klinikk, Aalesund, Norway; 3 Stavanger University Hospital, Stavanger, Norway;
4 Rikshospitalet University Hospital, Oslo, Norway
This work presents a method for improving diagnostic accuracy in DCE MR-mammography by normalization of kinetic parameters following AIF
deconvolution. The permeability related kinetic parameter Ktrans and the Ktrans-ratio between cancer tissue and breast parenchyma were investigated and
compared based on their ability to differentiate between malignant and benign lesions. The result showed that employing a normalization approach may
improve the diagnostically performance of the pharmacokinetic model by diminishing the prospective errors in the extracted AIF.
2477. Influence of Contrast Arrival Time and Temporal Resolution in Diagnosis of Breast Cancer with DCE-
MRI
Hendrik Laue 1 , Anja Hennemuth 1 , Volker Diehl 1,2 , Markus Thorsten Harz 1 , Horst Karl Hahn 1 , Heinz-Otto
Peitgen 1
1 Fraunhofer MEVIS, Bremen, Germany; 2 Institute of Magnetic Resonance Imaging, Central Hospital St.-Juergen-Strasse, Bremen,
Germany
The consensus on diagnosis of breast cancer with DCE-MRI is the use of sequences with high spatial and low temporal resolution, because of the in
inhomogeneous distribution of pharmacokinetic properties in the tumor and the requirement to detect small lesions. The diagnostic in breast MRI today is
therefore based on simple curve shapes rather than pharmacokinetic modeling. In this work, some pharmacokinetic modeling of contrast arrival time (CAT)
and variation of low temporal resolution are carried out to identify pitfalls in the application and to identify techniques beneficial for the diagnostic
performance of breast MRI.