TRADITIONAL POSTER - ismrm

Poster Sessions
1277. Serial Contrast-Enhanced Vessel Wall MRI in a Model of Plaque Neovascularization
Stephanie Elaine Chiu 1 , General Leung 1 , James Q. Zhan 2 , Alan R. Moody, 12
1 Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 2 Medical Imaging, Sunnybrook Health Sciences Centre,
Toronto, Ontario, Canada
This study introduces a measure extracted from gadofosveset-enhanced MR images of advanced rabbit atherosclerotic plaques for the study of plaque
neovascularization. Animals were scanned 1 week before, 5 weeks after, and 10 weeks after endothelial denudation of the abdominal aorta. Vessel wall
enhancement area measured from post-contrast MR images obtained prior to sacrifice was strongly associated with histologically-measured microvessel
count, intimal area, and macrophage area. Vessel wall enhancement area also monitored plaque development in the same group of animals over time. This
MR measure is suitable for the longitudinal study of changes in plaque neovascularization and inflammation.
1278. Magnetic Resonance Imaging of Inflammation in Abdominal Aortic Aneurysms Using USPIO
Jennifer Margaret Jane Richards 1 , Scott I. Semple 2 , Calum Gray 2 , William Wallace 3 , Roderick TA
Chalmers 4 , Olivier James Garden 5 , Graham McKillop 6 , David E. Newby 1
1 Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom; 2 Clinical Research Imaging Centre,
University of Edinburgh, Edinburgh, United Kingdom; 3 Department of Pathology, NHS Lothian, Edinburgh, United Kingdom;
4 Vascular Surgical Service, NHS Lothian, Edinburgh, United Kingdom; 5 Clinical and Surgical Sciences (Surgery), University of
Edinburgh, Edinburgh, United Kingdom; 6 Department of Radiology, NHS Lothian, Edinburgh, United Kingdom
The ability to evaluate the biological processes affecting the vessel wall in abdominal aortic aneurysms (AAA) would be beneficial in addition to vessel
diameter when evaluating the risk of aneurysm rupture. This is a clinical study (n=9) of the use of Magnetic Resonance Imaging and ultrasmall
superparamagnetic particles of iron oxide (USPIO, Sinerem, Guerbet) to detect focal areas of inflammation in the wall of AAA. A reduction in T2* value
was observed on T2* weighted imaging before and 24hrs after intravenous administration of 2.6mg/kg Sinerem. Histological examination of operative tissue
samples confirmed the presence of iron in the aortic wall.
1279. Preliminary Evaluation of the Short Term Reproducibility of Dynamic Contrast Enhanced (DCE)
MRI in Patients with Carotid Atherosclerosis
Claudia Calcagno 1 , Venkatesh Mani 1 , Sarayu Ramachandran 1 , Silvia Aguiar 1 , John Postley 2 , Zahi A.
Fayad 1
1 Radiology, Mount Sinai School of Medicine, New York, NY, United States; 2 Columbia University - College of Physicians and
Surgeons
Dynamic contrast enhanced (DCE) MRI can quantify plaque inflammation in atherosclerosis, however its reproducibility is still unknown. We present a
preliminary study of the inter-scan reproducibility of the area under the curve (AUC) of contrast agent uptake calculated from DCE-MRI acquisitions in
patients with carotid atherosclerosis. We show excellent reproducibility of plaque AUC relative to ipsi-lateral sternocleidomastoideal muscle AUC (ICC
respectively 0.972 and 0.755, p