TRADITIONAL POSTER - ismrm

2038. Anatomical Assessment of the Optic Radiation in Children with Probabilistic Tractography
Michael Dayan 1 , Chris A. Clark 1
1 Radiology & Physics, UCL Institute of Child Health, London, United Kingdom
Poster Sessions
Temporal lobectomy, a surgical procedure notably carried out in children affected by intractable epilepsy, may be associated with visual field defects if the
optic radiation (OR) is damaged. The lack of data in children on the spatial dimensions and location of this pathway with highly variable anterior aspect,
Meyer’s loop (ML), lead us to reconstruct the OR in children in the age range 7 to 18 with probabilistic tractography. The segmentation was assessed by
computing two reference anatomical distances, the distance from ML to the temporal pole (ML-TP) and to the occipital pole (ML-OP), and comparing them
with other tractography and dissection studies in adults. A one sample t-test showed a hemispheric dependence for ML-TP and ML-OP (p < 0.02) and a
multiple regression analysis demonstrated a gender dependence but no age effect. The distances reported in this study were similar to tractography and
dissection studies in adults. These data and the statistically significant dependence on gender and hemisphere are envisaged to be relevant when considering
neurosurgical planning for temporal lobectomy in children.
2039. White Matter Properties Predict the Speed of Neural Processing and Cortical Maturation in Children
Colleen Dockstader 1,2 , William Gaetz 3 , Conrad Rockel 1 , Donald Mabbott 1
1 Dept of Psychology/Division of Haemotology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada; 2 Dept of Anaesthesia
and Pain Medicine, The Hospital for Sick Children, Toronto, ON, Canada; 3 Biomagnetic Imaging Laboratory, Children's Hospital of
Phiadelphia, Philadelphia, PA, United States
We investigated age-related changes in the latency of the P100m visual response in occipital cortex and the biophysical properties of white matter in eleven
healthy children to determine the impact of white matter growth on the maturation of neuronal signaling. Using TBSS, we found a significant relationship
between FA and P100m latency in the dorsal processing stream. The latency of the P100m was inversely related to FA and positively related to age. Our
findings suggest that simple measures of evoked latency on a visuomotor-attention task reflects dorsal stream integrity that is related to stage of cortical
maturation in healthy children.
2040. Precision and Accuracy of Arterial Spin Labeling Perfusion MRI in the Pediatric Population
Varsha Jain 1 , Mariel Giannetta 1 , Michael Langham 1 , Sharon Xie 1 , Daniel Licht 1 , Joan Giannetta 1 , Timothy
Roberts 2 , John Detre 1 , Hallam Hurt 2 , Felix Wehrli 1 , Jiongjiong Wang 1
1 University of Pennsylvania, Philadelphia, PA, United States; 2 Children's Hospital of Philadelphia, Philadelphia, PA, United States
We evaluated the precision and accuracy of absolute CBF measurements using two arterial spin labeling (ASL) techniques, pulsed ASL (PASL) and pseudocontinuous
ASL (pCASL) in a typical developing cohort of 18 healthy children 7 to 17 years old. Longitudinal reproducibility (precision) was assessed by
repeated scans 2-4 weeks apart, while accuracy was assessed by comparison with total blood flow volume measured by phase-contrast (PC) MRI at the
labeling plane. The results demonstrate excellent precision (ICC=0.62) and accuracy (ICC=0.77) of quantitative CBF measured by pCASL.
2041. Optimisation of Fast Quantitative T2 Imaging of the Premature Brain: A Fantom Study
Laetitia Maurin 1,2 , Dominique Sirinelli 2 , Jean Philippe Cottier, 1,3 , Laurent Barantin 1,2
1 NMR Department, UMR Inserm U 930 - CNRS ERL 3106 - Université François Rabelais de Tours, TOURS, France; 2 Pediatric
Radiology, CHRU de TOURS, TOURS, France; 3 Neuroradiology, CHRU de TOURS, TOURS, France
The aim of this work was to optimize and compare different T2 sequences so we could find one suitable for quantitative study of premature newborn brain.
Four sequences were tested. After mathematical correction, T2 values found for each sequence were comparable to those calculated by the reference
sequence. We choose the SSFSE sequence for premature T2 maps due to its duration. This sequence was optimized in order to decrease final acquisition
time. This work allowed us to create a sequence, SSFSE 4 echoes, reliable and reproducible to calculate pediatric neurologic T2 maps with duration suitable
for routine clinical practice.
2042. Investigating the Need and Feasibility of Cardiac Triggering for Diffusion Imaging Data in Neonatal
Subjects
Lajos R. Kozak 1 , Gábor Rudas 1 , Zoltán Vidnyánszky 1,2 , Zoltán Nagy 3
1 MR Research Center, Semmelweis University, Budapest, Hungary; 2 Neurobionics Research Group, Hungarian Academy of Sciences
- Pázmány Péter Catholic University - Semmelweis University, Budapest, Hungary; 3 Wellcome Trust Centre for Neuroimaging, UCL
Institute of Neurology, London, United Kingdom
The feasibility of cardiac triggered diffusion data acquisition in a pediatric population was investigated. Data was collected with and without cardiac
triggering either along the z gradient direction and then subjected to bootstrap statistics (3 subjects) or in 15 non-collinear directions and fitted to a tensor
model (3 subjects). We found that cardiac triggering decreases the variability in the data without a significant increase in acquisition time in the investigated
pediatric population.
2043. RF Shield Coat for Mother to Be in the Magnet with Her Child.
Shin-ichi Urayama 1 , Naozo Sugimoto 2 , Hidenao Fukuyama 1
1 Human Brain Research Center, Kyoto University, Kyoto, Japan; 2 School of Health Sciences, Faculty of Medicine, Kyoto University,
Kyoto, Japan
For pediatric imaging, accompanying scan, in which an accompanying person wearing an RF shield coat is in the magnet with the child, was examined.
Although there are two problems, peripheral nerve stimulation and SNR reduction, this technique is proved to be a feasible solution to avoid risks in
pediatric imaging.