TRADITIONAL POSTER - ismrm

Poster Sessions
1948. Fully-Automated MRI Quantification of Lateral-Ventricle Volume and Volume-Change in Patients
with Alzheimer’s Disease
Zografos Caramanos 1,2 , Vladimir S. Fonov 3 , Jacqueline T. Chen, 2,3 , Simon J. Francis, 2,3 , Alexandre
Carmel-Veilleux 3,4 , Sridar Narayanan, 2,3 , D Louis Collins 3 , Douglas L. Arnold, 2,3
1 McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec , Canada; 2 NeuroRx
Research, Montreal, Quebec, Canada; 3 McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University,
Montreal, Quebec, Canada; 4 NeuroRx Research, Montreal, Quebec , Canada
Precise and accurate quantification of the volume, and longitudinal change in volume, of the lateral ventricles (LV) based on MRI data is an important goal
in understanding the natural progression of neurodegenerative disorders such as Alzheimer’s disease (AD) and multiple sclerosis. In the present study, we
provide evidence from 270 AD patients for the accuracy of a novel, fully-automated, MRI-based technique for LV segmentation. Furthermore, we provide
preliminary evidence (from a subset of 33 of these patients) for the validity and precision of two novel, fully-automated, MRI-based techniques for the
estimation of longitudinal change in LV volume.
1949. A Study of APOE and Cerebral Perfusion in Adult Offspring of Patients with Alzheimer's Dementia
Using Dynamic Susceptibility Contrast MRI
Rachel DiAnne McKinsey 1 , Zhifei Wen 1 , Alan McMillian 1 , Beth Meyerand 1 , Sterling Johnson 2 , Sean
Fain 1,3 , Cindy Carlsson 2
1 Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 2 GRECC, Veteran Administration Hospital,
Madison, WI, United States; 3 Radiology, University of Wisconsin-Madison, Madison, WI, United States
APOE and vascular dysfunction are associated with increased risk of AD. Changes in perfusion have been identified in APOE carriers verse non-carriers.
The application of DSC perfusion with intravenous gadolinium contrast injection to investigate perfusion changes in AD has the ability to provide CBF,
CBV, and MTT perfusion maps. We investigated the ability of DSC MRI to measure CBV, CBF, and MTT changes in non-demented children with
increased risk for AD due to one or more risk factors: APOE and/or family history.
1950. Alteration of Integrity and Patterns of the Memory Modules in Mild Cognitive Impairment and
Alzheimer's Disease
Guangyu Chen 1 , Piero Antuono 2 , Shi-Jiang Li 1
1 Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 2 Neurology, Medical College of Wisconsin, Milwaukee,
WI, United States
We tested a hypothesis that the integrity and organization patterns of specific modules (HIP-TP) responsible for memory processing are altered in Mild
Cognitive Impairment (MCI) and Alzheimer's disease (AD) subjects, in comparison with cognitively normal (CN) subjects. HIP-TP in CN is very well
organized and has highly directed connected bilateral symmetric regions, but the MCI and AD HIP-TP module have fewer directed left and right
connections, and the modules are hardly symmetric and organized. There is a potential that patterns of the HIP-TP modules could be employed to distinguish
MCI subjects from CN subjects.
1951. Dynamic Changes in Causal Strength in Memory Encoding Networks in Alzheimer’s Disease Detected
by Granger Causality Analysis
Guangyu Chen 1 , B. Douglas Ward 1 , Shi-Jiang Li 1
1 Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States
A quantitative Granger causality analysis, which can measure the causal strength among different time series, was employed to identify and quantify the
directional hippocampus and default model network in cognitively normal subjects, and detect the changes in the directional network in AD patients.
Interestingly in AD subjects, the functional afferents of parahippocampal gyrus is significantly decreased but the efferents of that are increased. And the
abnormal network are correlated with abnormal behaviors.
1952. Diffusion Tensor Imaging in Patients with Alzheimer’s Disease and Mild Cognitive Impairment
Sidy Fall 1 , Souraya El Sankari 2 , Roger Bouzerar 3 , Bertille Perin 4 , Marc-Etienne Meyer 5 , Olivier Baledent 3
1 Imaging and Biophysics, University Hospital , Amiens, Picardie, France; 2 Institute of Neuroscience, Cliniques Universitaires Saint-
Luc, Brussels, Belgium; 3 Imaging and Biophysics, University Hospital, Amiens, Picardie, France; 4 Neurology , University Hospital,
Amiens, Picardie, France; 5 Nuclear Medicine, University Hospital, Amiens, Picardie, France
We used DTI to investigate inferior fronto-occipital fasciculus (IFO) alterations in patients with Alzheimer’s disease and Mild Cognitive Impairment (MCI).
Within each group, we compared DTI parameters between the two hemispheres in IFO. We found no differences in DTI parameters between the two patients
groups. Our results reveal that the longitudinal and radial diffusivities, fractional anisotropy and apparent diffusion coefficient were significantly higher on
the right lobe than on the left lobe in AD group. While, Within the MCI group, only FA and radial diffusivity were higher on the right lobe than on the left
lobe.