TRADITIONAL POSTER - ismrm

Poster Sessions
2563. Quantitative Assessment of Idiopathic Pulmonary Fibrosis with Hyperpolarized Gas MRI
Michael J. Stephen 1 , Kiarash Emami 2 , John M. Woodburn 2 , Elaine Chia 2 , Stephen J. Kadlecek 2 , Jianliang
Zhu 3 , Masaru Ishii 4 , Milton Rossman 1 , Benjamin Pullinger 2 , Stephen Pickup 2 , Rahim R. Rizi 2
1 Department of Pulmonary and Critical Care, University of Pennsylvania, Philadelphia, PA, United States; 2 Department of Radiology,
University of Pennsylvania, Philadelphia, PA, United States; 3 Department of Surgery, VA Medical Center, Philadelphia, PA, United
States; 4 Department of Otolaryngology, Johns Hopkins University, Baltimore, MD, United States
This study demonstrates the first attempt to use hyperpolarized gas MR images of lung ventilation and apparent diffusion (ADC) in an animal model of
interstitial lung disease. The efficacy of hyperpolarized 3 He MRI metrics in assessing idiopathic pulmonary fibrosis (IPF) was evaluated in a bleomycin rat
model. Results showed that fractional ventilation 3 weeks after bleomycin administration was significantly lower than in the control animals, and ADC
measurements followed similar trends. Hyperpolarized gas MRI is a promising diagnostic for IPF and an improvement over current diagnostics in its
regional sensitivity and benignancy.
2564. Regional Pulmonary Pressure Over Volume Curves of the Rat Lung Measured by Polarized 3He
Magnetic Resonance Imaging
Angelos Kyriazis 1,2 , Ignacio Rodriguez 1,2 , Jose-Manuel Perez-Sanchez 3 , Lars E. Olsson 4 , Jesus Ruiz-
Cabello 1,2
1 Universidad Complutense de Madrid, Instituto de Estudios Biofuncionales, Madrid, Spain; 2 CIBER de Enfermedades Respiratorias,
Spain; 3 Orsay and Kremlin-Bicetre, U2R2M, Paris, France; 4 DECS Imaging, AstraZeneca R&D, Mölndal, Sweden
A method to estimate regional lung volume over time based on spin-density 3He images is presented. Combining this with the tracheal pressure, regional
volume over pressure is appraised. The static ROI are the left and the right lobe of the lung. Physiological parameters were calculated for the two ROI and
for the whole lung. The method is proven reproducible because the measurements of the ROI of the same animal as well as the measurements of different
animals agreed satisfactorily. The method may differentiate not only healthy from diseased animals but also healthy from diseased areas of the lung.
2565. In Vivo Comparison of 2D and 3D T2* in the Rat Lung Using Hyperpolarized Helium-3 MRI at 1.5 T
Kyle Hill 1,2 , José-Manuel Pérez-Sánchez 2 , Roberta Santarelli 2 , Mathieu Sarracanie 2 , Pascal Hagot 2 ,
Marlies Friese 2 , Xavier Maître 2 , Luc Darrasse 2
1 University of Oxford, Oxford, Oxfordshire, United Kingdom; 2 Imagerie par Résonance Magnétique Médicale et Multimodalité
(UMR 8081), Univ Paris-Sud, CNRS, Paris, Le Kremlin-Bicêtre, France
The T¬2* of hyperpolarized helium-3 in the lungs has shown promise in characterizing lung microstructure due to its sensitivity to local gradients caused by
gas-tissue interfaces, whose abundance per unit volume changes with lung inflation and pathological modification. Despite the lung’s three-dimensional
structure, most measurements of helium-3 T¬2* have been performed using projection imaging which neglects the complex microstructure’s effects. This
work uses five rats in vivo to compare the T2* in a projection image with 3D imaging and shows that 3D is necessary to detect statistically different local
phenomena that may not be apparent in projection imaging.
2566. Gravity Dependent Ventilation of Rats Measured by Hyperpolarised Helium MRI and Electric
Impedence Tomography
Marlies Elly Joy Friese 1 , Kimble R. Dunster, 12 , Gary J. Cowin 1 , Deming Wang 1 , Graham Galloway 1 , John
Fraser 3,4 , Andreas Schibler, 4,5
1 Centre for Magnetic Resonance, The University of Queensland, Brisbane, Queensland, Australia; 2 Medical Engineering Research
Facility,, Queensland University of Technology, Brisbane, Queensland, Australia; 3 Paediatric Intensive Care Unit,, Mater Children’s
Hospital, Brisbane, Queensland, Australia; 4 Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland,
Australia; 5 Paediatric Intensive Care Unit, Mater Children’s Hospital, Brisbane, Queensland, Australia
Gravity-dependent ventilation distribution was investigated in using both hyperpolarised helium-3 magnetic resonance imaging (HP3He MRI) and electrical
impedance tomography (EIT). Time averaged EIT data and HP3HeMRI images of apnoea showed ventilation distribution in rats to be gravity dependent,
whereas regional filling characteristics are dependent on anatomy. HP3He MRI and EIT data agree where they can be compared. HP3He MRI provides data
on real geometry which EIT cannot as EIT tomograms are reconstructed to a circular image. Dynamic imaging of the breathing cycle with HP3He is still
needed to make a full comparison of the two methods.
2567. Respiratory Impedance in a Mouse Model of Asthma Using Hyperpolarized 3 He MR Imaging
Suryanarayanan Sivaram Kaushik 1 , John Nouls 1 , Erin Potts 2 , Zackary Cleveland 1 , W Michael Foster 2 ,
Bastiaan Driehuys 1
1 Center for In-Vivo Microscopy, Duke University Medical Center, Durham, NC, United States; 2 Pulmonary and Critical Care
Medicine, Duke University Medical Center, Durham, NC, United States
The broncho-constriction and inflammation associated with asthma contributes to increased airway impedance. This impedance is typically measured using
global respiratory mechanics techniques such as FlexiVent. However, the time course of broncho-constriction can also be directly visualized using
hyperpolarized (HP) 3He MRI. This imaging-based technique provides a time-dependent method for quantifying central airway impedance and may be
useful to assess the regional contributions to globally measured impedance. Here, we discuss the method we used in obtaining the upper airway impedance
during a Methacholine (Mch) challenge, in a mouse model of asthma.