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Poster Sessions<br />

2563. Quantitative Assessment of Idiopathic Pulmonary Fibrosis with Hyperpolarized Gas MRI<br />

Michael J. Stephen 1 , Kiarash Emami 2 , John M. Woodburn 2 , Elaine Chia 2 , Stephen J. Kadlecek 2 , Jianliang<br />

Zhu 3 , Masaru Ishii 4 , Milton Rossman 1 , Benjamin Pullinger 2 , Stephen Pickup 2 , Rahim R. Rizi 2<br />

1 Department of Pulmonary and Critical Care, University of Pennsylvania, Philadelphia, PA, United States; 2 Department of Radiology,<br />

University of Pennsylvania, Philadelphia, PA, United States; 3 Department of Surgery, VA Medical Center, Philadelphia, PA, United<br />

States; 4 Department of Otolaryngology, Johns Hopkins University, Baltimore, MD, United States<br />

This study demonstrates the first attempt to use hyperpolarized gas MR images of lung ventilation and apparent diffusion (ADC) in an animal model of<br />

interstitial lung disease. The efficacy of hyperpolarized 3 He MRI metrics in assessing idiopathic pulmonary fibrosis (IPF) was evaluated in a bleomycin rat<br />

model. Results showed that fractional ventilation 3 weeks after bleomycin administration was significantly lower than in the control animals, and ADC<br />

measurements followed similar trends. Hyperpolarized gas MRI is a promising diagnostic for IPF and an improvement over current diagnostics in its<br />

regional sensitivity and benignancy.<br />

2564. Regional Pulmonary Pressure Over Volume Curves of the Rat Lung Measured by Polarized 3He<br />

Magnetic Resonance Imaging<br />

Angelos Kyriazis 1,2 , Ignacio Rodriguez 1,2 , Jose-Manuel Perez-Sanchez 3 , Lars E. Olsson 4 , Jesus Ruiz-<br />

Cabello 1,2<br />

1 Universidad Complutense de Madrid, Instituto de Estudios Biofuncionales, Madrid, Spain; 2 CIBER de Enfermedades Respiratorias,<br />

Spain; 3 Orsay and Kremlin-Bicetre, U2R2M, Paris, France; 4 DECS Imaging, AstraZeneca R&D, Mölndal, Sweden<br />

A method to estimate regional lung volume over time based on spin-density 3He images is presented. Combining this with the tracheal pressure, regional<br />

volume over pressure is appraised. The static ROI are the left and the right lobe of the lung. Physiological parameters were calculated for the two ROI and<br />

for the whole lung. The method is proven reproducible because the measurements of the ROI of the same animal as well as the measurements of different<br />

animals agreed satisfactorily. The method may differentiate not only healthy from diseased animals but also healthy from diseased areas of the lung.<br />

2565. In Vivo Comparison of 2D and 3D T2* in the Rat Lung Using Hyperpolarized Helium-3 MRI at 1.5 T<br />

Kyle Hill 1,2 , José-Manuel Pérez-Sánchez 2 , Roberta Santarelli 2 , Mathieu Sarracanie 2 , Pascal Hagot 2 ,<br />

Marlies Friese 2 , Xavier Maître 2 , Luc Darrasse 2<br />

1 University of Oxford, Oxford, Oxfordshire, United Kingdom; 2 Imagerie par Résonance Magnétique Médicale et Multimodalité<br />

(UMR 8081), Univ Paris-Sud, CNRS, Paris, Le Kremlin-Bicêtre, France<br />

The T¬2* of hyperpolarized helium-3 in the lungs has shown promise in characterizing lung microstructure due to its sensitivity to local gradients caused by<br />

gas-tissue interfaces, whose abundance per unit volume changes with lung inflation and pathological modification. Despite the lung’s three-dimensional<br />

structure, most measurements of helium-3 T¬2* have been performed using projection imaging which neglects the complex microstructure’s effects. This<br />

work uses five rats in vivo to compare the T2* in a projection image with 3D imaging and shows that 3D is necessary to detect statistically different local<br />

phenomena that may not be apparent in projection imaging.<br />

2566. Gravity Dependent Ventilation of Rats Measured by Hyperpolarised Helium MRI and Electric<br />

Impedence Tomography<br />

Marlies Elly Joy Friese 1 , Kimble R. Dunster, 12 , Gary J. Cowin 1 , Deming Wang 1 , Graham Galloway 1 , John<br />

Fraser 3,4 , Andreas Schibler, 4,5<br />

1 Centre for Magnetic Resonance, The University of Queensland, Brisbane, Queensland, Australia; 2 Medical Engineering Research<br />

Facility,, Queensland University of Technology, Brisbane, Queensland, Australia; 3 Paediatric Intensive Care Unit,, Mater Children’s<br />

Hospital, Brisbane, Queensland, Australia; 4 Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland,<br />

Australia; 5 Paediatric Intensive Care Unit, Mater Children’s Hospital, Brisbane, Queensland, Australia<br />

Gravity-dependent ventilation distribution was investigated in using both hyperpolarised helium-3 magnetic resonance imaging (HP3He MRI) and electrical<br />

impedance tomography (EIT). Time averaged EIT data and HP3HeMRI images of apnoea showed ventilation distribution in rats to be gravity dependent,<br />

whereas regional filling characteristics are dependent on anatomy. HP3He MRI and EIT data agree where they can be compared. HP3He MRI provides data<br />

on real geometry which EIT cannot as EIT tomograms are reconstructed to a circular image. Dynamic imaging of the breathing cycle with HP3He is still<br />

needed to make a full comparison of the two methods.<br />

2567. Respiratory Impedance in a Mouse Model of Asthma Using Hyperpolarized 3 He MR Imaging<br />

Suryanarayanan Sivaram Kaushik 1 , John Nouls 1 , Erin Potts 2 , Zackary Cleveland 1 , W Michael Foster 2 ,<br />

Bastiaan Driehuys 1<br />

1 Center for In-Vivo Microscopy, Duke University Medical Center, Durham, NC, United States; 2 Pulmonary and Critical Care<br />

Medicine, Duke University Medical Center, Durham, NC, United States<br />

The broncho-constriction and inflammation associated with asthma contributes to increased airway impedance. This impedance is typically measured using<br />

global respiratory mechanics techniques such as FlexiVent. However, the time course of broncho-constriction can also be directly visualized using<br />

hyperpolarized (HP) 3He MRI. This imaging-based technique provides a time-dependent method for quantifying central airway impedance and may be<br />

useful to assess the regional contributions to globally measured impedance. Here, we discuss the method we used in obtaining the upper airway impedance<br />

during a Methacholine (Mch) challenge, in a mouse model of asthma.

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