TRADITIONAL POSTER - ismrm

Poster Sessions
2345. Quantitative Measurements of Cerebral Oxygen Extraction Fraction for Rabbits with Carotid
Occlusion Using MRI
Xiaodong Zhang 1 , Chao He 2 , Lihong Hui 3 , Xiaoying Wang, 1,3 , Sheng Xie 3 , Jiangxi Xiao 3 , Hongyu An 4 , Jue
Zhang 1,2 , Jing Fang 1,2
1 Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China; 2 College of Engineering, Peking University,
Beijing, China; 3 Dept.of Radiology, Peking University First Hospital, Beijing, China; 4 Dept. of Radiology, University of North
Carolina at Chapel Hill, Chapel Hill, NC, United States
Cerebral oxygen extraction factor (OEF) provides critically important information to assess the brain oxygen metabolism in both normal and disease states.
It has been reported that the OEF could be evaluated for healthy human volunteers using MRI. In this study, a based gradient echo sampling of the spin echo
(GESSE) sequence implemented on GE 3.0T scanner to evaluate the cerebral OEF distribution of rabbits before and after carotid artery occlusion operation.
Our study demonstrated a consistent and significant increase of OEF in rabbits post carotid artery occlusion, suggesting that this MR based method can be
utilized to detect pathophysiological changes in cerebral oxygenation.
2346. Myelin Water Imaging of Children with Diverse Reading Ability
Eugene Yip 1 , Pauline Low 2 , Burkhard Mädler, 1,3 , Catherine Lebel 4 , Christian Beaulieu 4 , Linda Siegel 2 ,
Alex Mackay 1
1 Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada; 2 Department of
Education and Counselling Psychology, and Special Education, University of British Columbia, Vancouver, British Columbia,
Canada; 3 Philips Medical Systems; 4 Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
Magnetic resonance imaging provides a mean to non-invasively investigate the neurological cause of dyslexia, a learning disability that affects one’s ability
to read despite adequate intelligence. Myelin water imaging, based on calculating the myelin water fraction from multi-echo T2 relaxation curves, can be
used to quantitatively assess white matter. In this study, myelin water imaging and cognitive and reading assessments were performed on children with a
wide range of reading ability in order to investigate the relationship between dyslexia and white matter development in the brain.
2347. Improving Characterization of Traumatic Brain Injury by Synergistic Use of Multi-MRI Techniques
Zhifeng Kou 1 , Robin Hanks, Scott Millis, Randall Benson, Ramtilak Gattu, E Mark Haacke 1
1 Radiology, Wayne State University School of Medicine, Detroit, MI, United States
There is no treatment of TBI partially due to the current clinical classification system cannot effectively identify the pathoanatomical information of the
brain. We propose that a synergistic use of multi-imaging techniques may capture much of the heterogeneity and complexity of brain injury in individual
patients therefore result in improved accuracy and detail in prognostic models and improved efficiency of clinical trials. In this study, we report our
preliminary observations regarding the synergistic use of these three MRI techniques in an improved characterization of TBI.
2348. 4D Flow Measurement of Cerebrospinal Fluid Pulsation at the Craniocervical Junction and Cervical
Spine and Its Clinical Potential
Alexander Christian Bunck 1 , Wolfram Schwindt 1 , Jan-Robert Kröger 1 , Alena Jüttner 1 , Angela Brentrup 2 ,
Barbara Fiedler 3 , Gerard Crelier 4 , Walter Heindel 1 , David Maintz 1 , Thomas Niederstadt 1
1 Department of Clinical Radiology, University hospital of Muenster, Muenster, Germany; 2 Department of Neurosurgery, University
hospital of Muenster, Muenster, Germany; 3 Department of Paediatrics, University hospital of Muenster, Muenster, Germany; 4 Institute
for Biomedical Engineering, ETH Zurich, Zurich, Switzerland
Time resolved 3D-phase contrast imaging allows to assess cerebrospinal fluid pulsation at the craniocervical junction and cervical spine. Using state-of-theart
visualization techniques it helps to identify and differentiate between pathological and physiological cerebrospinal fluid flow pattern. As such it may add
valuable information for the analysis of pathologies associated with altered cerebrospinal fluid flow like in Chiari malformations and may promote a better
understanding of the underlying pathophysiology of these diseases.
2349. Differentiating Haematoma with the R 2 ' Relaxation Rate
Gopal Varma 1 , Prakash Saha 2 , Matt Waltham 2 , Stephen Keevil 1,3 , Alberto Smith 2 , Tobias Schaeffter 1
1 Imaging Sciences, King's College London, London, United Kingdom; 2 Academic Department of Surgery, King's College London,
London, United Kingdom; 3 Medical Physics, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
Subdural haematoma (SDH) is an emergency when acute, and management is often guided by imaging. Distinguishing between the different phases of SDH
may be possible by the presence and position of methaemoglobin. In this study, we create an in vitro system of SDH and examine the relationship between
intra- and extracellular methaemoglobin at various concentrations, using R2, R2* and R2†parameters. R2†relaxation rate appears to be the most
sensitive marker of methaemoglobin concentration and can readily differentiate between when it is intra- or extracellular. This parameter could therefore be
used to stage the phase of SDH.
2350. Hyperintense Carotid Plaque on T 1 -Weighted TFE MRI in Symptomatic Patients with Low Grade
Carotid Stenosis and Carotid Occlusion
Anja Gwendolyn van der Kolk 1 , Gert Jan de Borst 2 , Anne G. den Hartog 2 , M Eline Kooi 3 , Willem PThM
Mali 1 , Jeroen Hendrikse 1
1 Department of Radiology, University Medical Center, Utrecht, Netherlands; 2 Department of Vascular Surgery, University Medical
Center, Utrecht, Netherlands; 3 Department of Radiology, University Medical Center, Maastricht, Netherlands
The carotid MR hyperintense (vulnerable) plaque is associated with a higher morbidity and mortality. We investigated the prevalence of this plaque and its
clinical correlates on T 1 -weighted turbo-field echo (T 1 w-TFE) MRI in patients with ischemic symptoms and varying degrees of stenosis. 153 patients with
TIA or ischemic infarct were retrospectively examined. 18% showed one or more hyperintense plaques. Half of all hyperintense plaques occurred in