TRADITIONAL POSTER - ismrm

Poster Sessions
2146. Comparison of Different CSF Correction Methods in a MRS Study of Depressed Psychiatric Patients
John DeWitt Port 1 , Ileana Hancu 2 , Heidi Alyssa Edmonson 1 , Zhonghao Bao 3 , Mark A. Frye 4
1 Radiology, Mayo Clinic, Rochester, MN, United States; 2 GE Global Research Center, Niskayuna, NY, United States; 3 Information
Services, Mayo Clinic, Rochester, MN, United States; 4 Psychiatry, Mayo Clinic, Rochester, MN, United States
Various methods have been used to correct for the amount of CSF within spectroscopic voxels. However, it remains unclear which method is best. We
performed CSF correction on an MRS dataset comparing depressed psychiatric patients to normal controls, using the ratio to creatine as well as two
anatomically-based CSF correction methods. All three CSF correction methods yielded significant results for most statistical comparisons; ROC analysis
demonstrated no single CSF correction technique to be better than the others. If the metabolite value used in the denominator is stable, ratios may actually
improve statistical sensitivity relative to anatomically-based CSF correction methods.
2147. fMRI and Connectivity Effects of Electro-Convulsive Therapy (ECT) in Depressed Patients
Erik B. Beall 1 , Mark J. Lowe 1 , Michael D. Phillips 1 , Steve Jones 1 , Pallab K. Bhattacharyya 1 , David
Muzina 2
1 Radiology, Cleveland Clinic, Cleveland, OH, United States; 2 Psychiatry, Cleveland Clinic, Cleveland, OH, United States
ECT is a safe and effective treatment for depression. However its mechanisms have not been studied with the BOLD effect in a pre- and post-ECT fMRI and
connectivity study. We present preliminary results that show reduced activation and connectivity in response to working memory and affective tasks.
2148. Decreased Anterior Cingulate Cortex GABA in Depressed Adolescents Measured by Proton MRS at
3T
Vilma Gabbay 1 , Xiangling Mao 2 , Yisrael Katz 1 , Aviva Pazner 1 , James S. Babb 1 , Dikoma C. Shungu 2
1 NYU Child Study Center, NYU School of Medicine, New York, NY, United States; 2 Radiology, Weill Cornell Medical College,
New York, NY, United States
Adolescent major depressive disorder (MDD) is a serious public health concern as it often leads to suicide. However, limited research has been conducted to
date in this clinical population. This is the first study to examine in vivo γ-aminobutyric acid (GABA) in adolescents with MDD. Using proton MRS, levels
of GABA were measured in the anterior cingulate cortex of adolescents with MDD and found to be decreased compared to matched healthy control subjects.
This finding supports the notion that GABA abnormalities may be involved early in the etiology of MDD.
2149. Reduced Functional Connectivity in Major Depression: A Whole Brain Study of Multiple Resting-
State Networks
Ilya M. Veer 1,2 , Christian F. Beckmann 3,4 , Evelinda Baerends 1,2 , Marie J. van Tol 1,5 , Luca Ferrarini 6 , Julien
R. Milles 6 , Dick J. Veltman 7 , Andre Aleman 8 , Mark A. van Buchem 1,2 , Nic J. van der Wee 1,5 , Serge A.
Rombouts 1,2
1 Leiden Institute for Brain and Cognition (LIBC), Leiden, Netherlands; 2 Department of Radiology, Leiden University Medical Center
(LUMC), Leiden, Netherlands; 3 FMRIB, University of Oxford, Oxford, United Kingdom; 4 Department of Clinical Neuroscience,
Imperial College London, London, United Kingdom; 5 Department of Psychiatry, Leiden University Medical Center (LUMC), Leiden,
Netherlands; 6 Department of Radiology, Division of Image Processing, Leiden University Medical Center (LUMC), Leiden,
Netherlands; 7 Department of Psychiatry, Free University Medical Center (VUMC), Amsterdam, Netherlands; 8 BCN Neuroimaging
Center, University of Groningen, Groningen, Netherlands
Major depression is associated with abnormal function of a large-scale mood processing and regulating brain circuit of interconnected regions. Therefore,
resting-state (RS) functional connectivity networks were investigated in a group of 19 medication-free patients diagnosed with major depressive disorder
without comorbidity, and 19 age- and gender-matched healthy controls. Using independent component, 13 relevant RS networks were found for the entire
group. Adopting a dual regression method, subject specific maps were calculated and subsequently used for permutation analysis. We found decreased
functional connectivity in three networks, which may relate to the affective and cognitive symptoms in major depression.
2150. Investigating Transverse Relaxation Time Abnormalities in Autism
Yann Gagnon 1,2 , N Rajakumar 3 , Neil Gelman 1,2 , Peter Williamson 3 , Dick Drost 1,2 , Jean Théberge 1,2 , Rob
Nicolson 3
1 Imaging, Lawson Health Research Institute, London, Ontario, Canada; 2 Medical Biophysics, University of Western Ontario, London,
Ontario, Canada; 3 Psychiatry, University of Western Ontario
Quantitative transverse relaxation time (T2) imaging offers a unique opportunity to evaluate the neurobiology of brain tissue. In the current study, we
further localize our previously reported overall white matter T2 increase in a sample of children with autism to developmentally relevant neuroanatomic
white matter regions.
2151. Aberrant Neurodevelopment of the Social Cognition Network During Adolescence in Autism
Spectrum Disorders
Chun-Wei Lan 1 , Kun-Hsien Chou 2 , I-Yun Chen 3 , Ya-wei Cheng 3 , Jean Decety 4 , Yang-Teng Fan 3 , Ching-Po
Lin 1,3
1 Institute of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan; 2 Institute of Biomedical
Engineering, National Yang Ming University, Taipei, Taiwan; 3 Institute of Neuroscience, National Yang Ming University, Taipei,
Taiwan; 4 Departments of Psychology and Psychiatry, The University of Chicago, Chicago, United States
The autism spectrum disorders (ASD), during childhood, undergoes precocious growth, followed by maturation deceleration. But how the ASD brain
changed during adolescence is unclear. We enrolled 25 male adolescents with ASD and 25 controls for voxel-based morphometric analysis. Global brain
volume enlargement of ASD did not persist into adolescence. The right inferior parietal lobule and posterior cingulate cortex, a role in social cognition, had a