TRADITIONAL POSTER - ismrm

Poster Sessions
2010. Correlation Between Venous Blood T1 and BOLD FMRI in Young and Elderly Subjects
Lirong Yan 1 , Yan Zhuo 1 , Bo Wang 1 , Cheng Li 2 , Jiongjiong Wang 2
1 Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; 2 Department of Radiology, University of Pennsylvania,
Philadelphia, PA, United States
We investigated the relationship between in vivo measurement of venous blood T1 and BOLD signal changes during visual stimulation in two groups of
young and elderly subjects. There was a significant negative correlation between venous blood T1 and BOLD activation across subjects. Upon including
venous blood T1 as a covariate, the differences in BOLD activation between the two age groups weakened, suggesting that aging effects on BOLD fMRI
may be partly attributed to baseline hematocrit variations.
2011. Increased Resting State Connectivity Between Left and Right Hemispheres with Increasing Age
Daniel Joshua Cox 1,2 , Rafat S. Mohtasib 3 , Daniela Montaldi 4 , Laura M. Parkes 1,2
1 Imaging Sciences and Biomedical Engineering, School of Cancer and Imaging Sciences, The University of Manchester, Manchester,
Lancashire, United Kingdom; 2 Biomedical Imaging Institute (BII), The University of Manchester, Manchester, Lancashire, United
Kingdom; 3 Magnetic Resonance and Image Analysis Research Centre (MARIARC), University of Liverpool, United Kingdom;
4 School of Psychological Sciences, The University of Manchester, Manchester, Lancashire, United Kingdom
This study aims to investigate changes in resting state functional connectivity with increasing age. 40 healthy subjects (aged 20 – 76) participated. Gradient
echo EPI images were collected during a Stroop task and active regions were found across the group. The BOLD amplitude in the right middle frontal gyrus
(MFG) increased with age, reducing laterality of activation. Partial correlation was used to investigate functional connectivity between bilateral MFG, which
was found to increase with age between bilateral MFG in adults aged 40yrs+. Increased connectivity was also associated with improved accuracy, suggesting
alterations in functional connectivity may be important for performance.
2012. Age-Related Effects on Resting State Default, Executive and Salience Networks Reveal Different
Pruning Mechanisms – a Resting State FMRI Study.
Vesa Kiviniemi 1 , Harri Littow 1 , Ahmed Abou-elseoud 1 , Katariina Mankinen 2 , Jukka Rahko 3 , Jukka Remes 1 ,
Juha Nikkinen 1 , Tuomo Starck 1 , Juha Veijola 4 , Christian Beckmann 5 , Osmo Tervonen 1
1 Diagnostic Radiology, Oulu University Hospital, Oulu, Finland; 2 Pediatric department, Oulu University Hospital, Oulu, Finland;
3 Child Psychiatry, Oulu University Hospital, Oulu, Finland; 4 Psychiatry, Oulu University, Oulu, Finland; 5 Clinical Neuroscience,
Imperial College, London, United Kingdom
Resting state networks undergo various age related changes both in strength and spatial distribution. Some occur in adolescence while many changes also
occur later in adulthood. A salience network splits without much strength in any age group. These different findings reflect multiple normal ageing processes
of the central nervous system.
2013. Age-Related Differences of Brain Activation Patterns Upon Imaginary Walking
Ekkehard Küstermann 1,2 , Markus Ebke 3 , Katja Dolge 4 , Natascha Lohr 1 , Dieter Leibfritz 2 , Manfred
Herrmann 1
1 ZKW/Neuropsychologie, Universität Bremen, Bremen, Germany; 2 Organische Chemie, Universität Bremen, Bremen, Germany;
3 Neurologie, Klinikum Bremen-Mitte, Bremen, Germany; 4 JCLLaID, Jacobs University Bremen, Bremen, Germany
The steadiness of walking decreases in elderly with advancing age. This study was designed to explore changes in the activation pattern during walking.
Healthy young and elderly subjects performed imaginated walking tasks while being scanned. Elderly subjects exhibited stronger and larger activations as
compared to younger subjects with a marked increase in the IPL. During imaginated walking, negative BOLD signal changes were only observed in
younger, but not in elderly subjects.
2014. Naming Errors and Gray Matter Structural Variations
Katie McMahon 1 , Anna Holmes 2 , Shiree Heath 2 , Anthony Angwin 3 , Lindsey Nickels 4 , Eril McKinnon 2 ,
Sophie Van Hees 2 , David Copland 2,3
1 Centre for Magnetic Resonance, University of Queensland, Brisbane, Queensland, Australia; 2 UQ Centre for Clinical Research,
University of Queensland, Australia; 3 School of Health and Rehabilitation Sciences, University of Queensland, Australia; 4 Macquarie
Centre for Cognitive Science (MACCS), Macquarie University, Sydney, NSW, Australia
The frequency of naming errors increases in normal aging. In this study we examined an elderly cohort of subjects; classified their naming difficulties and
correlated this with high resolution structural MRI images. Different regions were structurally correlated for reduced semantic, phonological and visual
perception errors, including the inferior temporal lobe, middle temporal lobe, and occipital-parietal regions.
2015. Correlations Between Semantic Priming, Word Recognition and Gray Matter Density
Katie McMahon 1 , Anthony Angwin 2 , Anna Holmes 3 , Shiree Heath 3 , Sophie Van Hees 3 , David Copland, 2,3
1 Centre for Magnetic Resonance, University of Queensland, Brisbane, Queensland, Australia; 2 School of Health and Rehabilitation
Sciences, University of Queensland, Australia; 3 UQ Centre for Clinical Research, University of Queensland, Australia
A normal elderly cohort was examined with MRI and a lexical access/semantic priming task. The priming effect (semantically related vs unrelated primetarget
pairs), and the word (semantic + unrelated response times) versus non-word targets were calculated. These variables were covaried with the individual
subjects’ high resolution MRI images, to investigate any possible structural dependencies. Structures of areas associated with attentional and semantic
priming networks were significant when compared against non-word responses, and areas of conceptual object knowledge and familiarity when compared
with the priming effect.