TRADITIONAL POSTER - ismrm

Poster Sessions
2819. Perfusion MRI of Solitary Pulmonary Nodules at 3T: Assessment of Perfusion Parameters and
Correlation with Histology
Hatsuho Mamata 1 , Junichi Tokuda 1 , Ritu Gill 1 , Robert F. Padera 2 , Robert E. Lenkinski 3 , David J.
Sugarbaker 4 , Hiroto Hatabu 1
1 Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; 2 Pathology, Brigham and
Women's Hospital, Harvard Medical School, Boston, MA, United States; 3 Radiology, Beth Israel Decones Medical Center, Harvard
Medical School, Boston, MA, United States; 4 Thoracic surgery, Brigham and Women's Hospital, Harvard Medical School, Boston,
MA, United States
Solitary pulmonary nodule (SPN) is one of the most common findings in chest imaging. It is important to avoid unnecessary intervention for benign lesions,
thereby lowering the associated mortality / morbidity. In this study, we applied perfusion MRI to evaluate perfusion characteristics of SPN and feasibility of
perfusion MRI as a diagnostic tool to differentiate malignant from benign SPN. Perfusion MRI parameters and TI curve has great potential to differentiate
malignant vs. benign SPN, thus to avoid unnecessary surgical interventions.
2820. Feasibility of Detecting Radiation-Induced Lung Injury in Non-Small Cell Lung Cancer Patients Using
Hyperpolarized Helium-3 MRI
Rob H. Ireland 1,2 , Omar S. Din 2 , James A. Swinscoe 2 , Edwin JR van Beek 3 , Matthew QF Hatton 2 , Jim M.
Wild 1
1 Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom; 2 Academic Unit of Clinical Oncology, University
of Sheffield, Sheffield, United Kingdom; 3 Department of Radiology, University of Iowa, Iowa, IA, United States
This preliminary work demonstrates the feasibility of pre-treatment assessment of lung ventilation and post-treatment detection of radiation-induced lung
damage using 3He-MRI for NSCLC patients.
2821. Intracellular Acidification of Human Melanoma Xenografts by the Respiratory Inhibitor Lonidamine
Plus Hyperglycemia: A 31P Magnetic Resonance Spectroscopy Study
Kavindra Nath 1 , Elliot C. Woods 1 , Seung Cheol Lee 1 , David S. Nelson 1 , Dennis B. Leeper 2 , Rong Zhou 1 ,
Lin Li 1 , Jerry D. Glickson 1
1 Radiology (Molecular Imaging Section), University of Pennsylvania, Philadelphia, PA, United States; 2 Radiation Oncology, Thomas
Jefferson University, Philadelphia, PA, United States
In vivo 31P magnetic resonance spectroscopy illustrates that human melanoma xenografts can be acidified by induction of hyperglycemia combined with
administration of lonidamine, an inhibitor of mitochondrial respiration. In melanoma xenograft (10-13 mm diameter), intracellular pH (pHi, measured by
chemical shift of the Pi resonance) was reduced by ~0.7 unit during i.v. infusion of glucose (0.6 M) for 120 min along with administration of lonidamine (50
mg/kg). Preliminary result of this study shows that lonidamine combined with hyperglycemia acidified human melanoma xenografts by reducing pHi, a
more critical parameter for thermosensitization to improve tumor response to alkylating agents.
2822. Monitoring Bone Marrow Changes During Chemoradiotherapy Using MRI Fat Quantification
Mark Bydder 1 , Yun Liang 2 , Huanzhou Yu 3 , Ann Shimakawa 3 , Jean Brittain 3 , Graeme Bydder 1 , Loren Mell 2
1 Radiology, University of California San Diego, San Diego, CA, United States; 2 Radiation Oncology, University of California San
Diego, San Diego, CA, United States; 3 GE Healthcare, Applied Science Lab, United States
The goal of this study was to evaluate a non-invasive magnetic resonance imaging method of fat quantification as a measure of yellow bone marrow in the
pelvis and spine. This is a new technology that will enable monitoring of response to therapy and assessment of the effectiveness of strategies to reduce
hematology toxicity.
2823. Motion-Sensitized Driven-Equilibrium (MSDE) Turbo Spin-Echo Sequence Increases Radiologists'
Diagnostic Performance in Detection of Brain Metastasis
Eiki Nagao 1 , Takashi Yoshiura 1 , Akio Hiwatashi 1 , Koji Yamashita 1 , Hironori Kamano 1 , Yukihisa
Takayama 1 , Tuvshinjargal Dashjamts 1 , Makoto Obara 2 , Tomoyuki Okuaki 2 , Hiroshi Honda 1
1 Clinical radiology of Kyushu-university, Fukuoka, Japan; 2 Philips Electoronics Japan
Motion-sensitized driven-equilibrium (MSDE) sequence has been reported to effectively suppress signals from flowing blood in vessels that can mimic the
brain metastases on post-contrast T1-weighted images. We performed an observer test to determine whether use of a 3D turbo spin-echo (TSE) sequence
with MSDE increases radiologistsf diagnostic performances in detecting brain metastases comparing to a conventional 3D gradient-echo sequence
(MPRAGE). A jackknife free-response receiver operating characteristic (JAFROC) analysis showed that TSE with MSDE increases radiologistsf
diagnostic performances compared to MPRAGE. The reading time was also significantly shortened by use of MSDE.
2824. Correlation of a Priori DCE-MRI Data with Ki-67 and HIF-1α Expression Levels in Neck Nodal
Metastases: Initial Analysis
Jacobus FA Jansen 1 , Diane Carlson 1 , Bhuvanesh Singh 1 , Hilda Stambuk 1 , Ya Wang 1 , Dennis Kraus 1 ,
Richard Wong 1 , Snehal Patel 1 , Jatin Shah 1 , Jason Koutcher 1 , Amita Shukla-Dave 1
1 MSKCC, NY, United States
Pretreatment DCE-MRI was performed on neck nodal metastases of 12 patients who underwent surgery. Surgical specimens were analyzed with
immunohistochemistry (IHC) assays for Ki-67 (reflecting cellular proliferation) and HIF-1α (hypoxia inducible transcription factor). Spearman correlation
was used to correlate DCE-MRI and molecular marker data. Significant correlation results were observed between DCE-MRI data (Ktrans and ve) and tumor
hypoxia, and proliferation as measured by Ki67 and HIF-1á expression levels, respectively. Future studies with larger patient populations need to be carried
out to confirm pretreatment DCE-MRI findings and molecular marker results in biopsy samples for better patient management.